Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
June-2014 Volume 7 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2014 Volume 7 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Association between the low‑dose irinotecan regimen‑induced occurrence of grade 4 neutropenia and genetic variants of UGT1A1 in patients with gynecological cancers

  • Authors:
    • Hiroyuki Moriya
    • Katsuhiko Saito
    • Nuala Helsby
    • Shigekazu Sugino
    • Michiaki Yamakage
    • Takeru Sawaguchi
    • Masahiko Takasaki
    • Hidenori Kato
    • Nahoko Kurosawa
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, Hokkaido Pharmaceutical University School of Pharmacy, Otaru, Japan, Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand, Department of Anesthesiology, Sapporo Medical University School of Medicine, Sapporo, Japan, Department of Pharmacy, National Hospital Organization Hokkaido Cancer Center, Sapporo, Japan, Department of Gynecology, National Hospital Organization Hokkaido Cancer Center, Sapporo, Japan
  • Pages: 2035-2040
    |
    Published online on: April 8, 2014
       https://doi.org/10.3892/ol.2014.2046
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The occurrence of severe neutropenia during treatment with irinotecan (CPT‑11) is associated with the *6 and *28 alleles of uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1). However, the correlation between these variants and the occurrence of severe neutropenia in a low‑dose CPT‑11 regimen for the treatment of gynecological cancers has not been extensively studied. There are also no studies regarding the association between the 421C>A mutation in ATP‑binding cassette sub-family G member 2 (ABCG2) and the occurrence of severe neutropenia in CPT‑11‑treated patients with gynecological cancers. The present study was designed to determine the factors associated with the occurrence of grade 4 neutropenia during chemotherapy for gynecological cancers with combinations of CPT‑11 and cisplatin or mitomycin C. In total, 44 patients with gynecological cancer were enrolled in the study. The association between the absolute neutrophil count (ANC) nadir values, the total dose of CPT‑11 and the genotypes of UGT1A1 or ABCG2 was studied. No correlation was observed between the ANC nadir values and the total dose of CPT‑11. The ANC nadir values in the UGT1A1*6/*28 and *6/*6 groups were significantly lower compared with those in the *1/*1 group (P<0.01). Univariate analysis showed no association between the occurrence of grade 4 neutropenia and the ABCG2 421C>A mutation. Subsequent to narrowing the factors by univariate analysis, multivariate logistic regression analysis only detected significant correlations between the occurrence of grade 4 neutropenia and the UGT1A1*6/*6 and *6/*28 groups (P=0.029; odds ratio, 6.90; 95% confidence interval, 1.22‑38.99). No associations were detected between the occurrence of grade 4 neutropenia and the heterozygous variant (*1/*6 or *1/*28) genotype, type of regimen or age. In conclusion, the UGT1A1*6/*28 and *6/*6 genotypes were found to be associated with the occurrence of severe neutropenia in the low‑dose CPT‑11 regimen for gynecological cancers. This finding indicates that the determination of UGT1A1 variants may be as useful in CPT‑11 chemotherapy for gynecological conditions as it is in colorectal and lung cancer patients treated with this drug.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Takano M, Kikuchi Y, Yaegashi N, et al: Adjuvant chemotherapy with irinotecan hydrochloride and cisplatin for clear cell carcinoma of the ovary. Oncol Rep. 16:1301–1306. 2006.PubMed/NCBI

2 

Tanaka H, Kihira T, Nomura Y and Ishihara A: Salvage chemotherapy with a combination of irinotecan hydrochloride and mitomycin C in elderly Japanese patients with gynecological malignancies: a pilot study. J Infect Chemother. 12:220–223. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Iyer L, Das S, Janisch L, et al: UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity. Pharmacogenomics J. 2:43–47. 2002.

4 

Innocenti F, Undevia SD, Iyer L, et al: Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan. J Clin Oncol. 15:1382–1388. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Rouits E, Boisdron-Celle M, Dumont A, Guérin O, Morel A and Gamelin E: Relevance of different UGT1A1 polymorphisms in irinotecan-induced toxicity: a molecular and clinical study of 75 patients. Clin Cancer Res. 10:5151–5159. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Han JY, Lim HS, Shin ES, et al: Comprehensive analysis of UGT1A polymorphisms predictive for pharmacokinetics and treatment outcome in patients with non-small-cell lung cancer treated with irinotecan and cisplatin. J Clin Oncol. 24:2237–2244. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Minami H, Sai K, Saeki M, et al: Irinotecan pharmacokinetics/pharmacodynamics and UGT1A genetic polymorphisms in Japanese: roles of UGT1A1*6 and *28. Pharmacogenet Genomics. 17:497–504. 2007.PubMed/NCBI

8 

Jada SR, Lim R, Wong CI, et al: Role of UGT1A1*6, UGT1A1*28 and ABCG2 c.421C>A polymorphisms in irinotecan-induced neutropenia in Asian cancer patients. Cancer Sci. 98:1461–1467. 2007.

9 

Hoskins JM, Goldberg RM, Qu P, Ibrahim JG and McLeod HL: UGT1A1*28 genotype and irinotecan-induced neutropenia: dose matters. J Natl Cancer Inst. 99:1290–1295. 2007.

10 

Sai K, Saito Y, Sakamoto H, et al: Importance of UDP-glucuronosyltransferase 1A1*6 for irinotecan toxicities in Japanese cancer patients. Cancer Lett. 261:165–171. 2008.

11 

Han JY, Lim HS, Park YH, Lee SY and Lee JS: Integrated pharmacogenetic prediction of irinotecan pharmacokinetics and toxicity in patients with advanced non-small cell lung cancer. Lung Cancer. 63:115–120. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Onoue M, Terada T, Kobayashi M, et al: UGT1A1*6 polymorphism is most predictive of severe neutropenia induced by irinotecan in Japanese cancer patients. Int J Clin Oncol. 14:136–142. 2009.

13 

Takano M, Kato M, Yoshikawa T, et al: Clinical significance of UDP-glucuronosyltransferase 1A1*6 for toxicities of combination chemotherapy with irinotecan and cisplatin in gynecologic cancers: a prospective multi-institutional study. Oncology. 76:315–321. 2009.

14 

Takahara N, Nakai Y, Isayama H, et al: Uridine diphosphate glucuronosyl transferase 1 family polypeptide A1 gene (UGT1A1) polymorphisms are associated with toxicity and efficacy in irinotecan monotherapy for refractory pancreatic cancer. Cancer Chemother Pharmacol. 71:85–92. 2013. View Article : Google Scholar

15 

Stewart CF, Panetta JC, O’Shaughnessy MA, et al: UGT1A1 promoter genotype correlates with SN-38 pharmacokinetics, but not severe toxicity in patients receiving low-dose irinotecan. J Clin Oncol. 25:2594–2600. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Sugiyama T, Hirose T, Kusumoto S, et al: The UGT1A1*28 genotype and the toxicity of low-dose irinotecan in patients with advanced lung cancer. Oncol Res. 18:337–342. 2010.

17 

Guillemette C: Pharmacogenomics of human UDP-glucuronosyltransferase enzymes. Pharmacogenomics J. 3:136–158. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Kaniwa N, Kurose K, Jinno H, et al: Racial variability in haplotype frequencies of UGT1A1 and glucuronidation activity of a novel single nucleotide polymorphism 686C> T (P229L) found in an African-American. Drug Metab Dispos. 33:458–465. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Kurose K, Sugiyama E and Saito Y: Population differences in major functional polymorphisms of pharmacokinetics/pharmacodynamics-related genes in Eastern Asians and Europeans: implications in the clinical trials for novel drug development. Drug Metab Pharmacokinet. 27:9–54. 2012. View Article : Google Scholar

20 

Imai Y, Nakane M, Kage K, et al: C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance. Mol Cancer Ther. 1:611–616. 2002.PubMed/NCBI

21 

Han JY, Lim HS, Yoo YK, et al: Associations of ABCB1, ABCC2, and ABCG2 polymorphisms with irinotecan-pharmacokinetics and clinical outcome in patients with advanced non-small cell lung cancer. Cancer. 110:138–147. 2007. View Article : Google Scholar : PubMed/NCBI

22 

National Cancer Institute. Common Terminology Criteria for Adverse Events v 3.0 (CTCAE). Cancer Therapy Evaluation Program. 2006.

23 

Moriya H, Saito K, Helsby N, et al: The association between heterozygosity for UGT1A1*6, UGT1A1*28, and variation in the serum total-bilirubin level in healthy young Japanese adults. Genet Test Mol Biomarkers. 17:464–469. 2013.

24 

Gao J, Zhou J, Li Y, Lu M, Jia R and Shen L: UGT1A1*6/*28 polymorphisms could predict irinotecan-induced severe neutropenia not diarrhea in Chinese colorectal cancer patients. Med Oncol. 30:6042013.

25 

Comella P, Farris A, Lorusso V, et al: Irinotecan plus leucovorin-modulated 5-fluorouracil I.V. bolus every other week may be a suitable therapeutic option also for elderly patients with metastatic colorectal carcinoma. Br J Cancer. 89:992–996. 2003. View Article : Google Scholar

26 

Chau I, Norman AR, Cunningham D, et al: Elderly patients with fluoropyrimidine and thymidylate synthase inhibitor-resistant advanced colorectal cancer derive similar benefit without excessive toxicity when treated with irinotecan monotherapy. Br J Cancer. 91:1453–1458. 2004. View Article : Google Scholar

27 

Souglakos J, Pallis A, Kakolyris S, et al: Combination of irinotecan (CPT-11) plus 5-fluorouracil and leucovorin (FOLFIRI regimen) as first line treatment for elderly patients with metastatic colorectal cancer: a phase II trial. Oncology. 69:384–390. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Rougier P, Bugat R, Douillard JY, et al: Phase II study of irinotecan in the treatment of advanced colorectal cancer in chemotherapy-naive patients and patients pretreated with fluorouracil-based chemotherapy. J Clin Oncol. 15:251–260. 1997.PubMed/NCBI

29 

Okuyama Y, Hazama S, Nozawa H, Kobayashi M, Takahashi K, Fujikawa K, Kato T, Nagata N, Kimura H, Oba K, Sakamoto J and Mishima H: Prospective phase II study of FOLFIRI for mCRC in Japan, including the analysis of UGT1A1 *28/*6 polymorphisms. Jpn J Clin Oncol. 41:477–482. 2011.

30 

Sunakawa Y, Ichikawa W, Fujita K, et al: UGT1A1*1/*28 and *1/*6 genotypes have no effects on the efficacy and toxicity of FOLFIRI in Japanese patients with advanced colorectal cancer. Cancer Chemother Pharmacol. 68:279–284. 2011.

31 

Cha PC, Mushiroda T, Zembutsu H, et al: Single nucleotide polymorphism in ABCG2 is associated with irinotecan-induced severe myelosuppression. J Hum Genet. 54:572–580. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Sai K, Saito Y, Maekawa K, et al: Additive effects of drug transporter genetic polymorphisms on irinotecan pharmacokinetics/pharmacodynamics in Japanese cancer patients. Cancer Chemother Pharmacol. 66:95–105. 2010. View Article : Google Scholar

33 

Cecchin E, Innocenti F, D’Andrea M, et al: Predictive role of the UGT1A1, UGT1A7, and UGT1A9 genetic variants and their haplotypes on the outcome of metastatic colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan. J Clin Oncol. 27:2457–2465. 2009. View Article : Google Scholar

34 

Lévesque E, Bélanger AS, Harvey M, et al: Refining the UGT1A haplotype associated with irinotecan-induced hematological toxicity in metastatic colorectal cancer patients treated with 5-fluorouracil/irinotecan-based regimens. J Pharmacol Exp Ther. 345:95–101. 2013.

35 

Glimelius B, Garmo H, Berglund A, et al: Prediction of irinotecan and 5-fluorouracil toxicity and response in patients with advanced colorectal cancer. Pharmacogenomics J. 11:61–71. 2011. View Article : Google Scholar : PubMed/NCBI

36 

van der Bol JM, Mathijssen RH, Loos WJ, et al: Cigarette smoking and irinotecan treatment: pharmacokinetic interaction and effects on neutropenia. J Clin Oncol. 25:2719–2726. 2007.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Moriya H, Saito K, Helsby N, Sugino S, Yamakage M, Sawaguchi T, Takasaki M, Kato H and Kurosawa N: Association between the low‑dose irinotecan regimen‑induced occurrence of grade 4 neutropenia and genetic variants of UGT1A1 in patients with gynecological cancers. Oncol Lett 7: 2035-2040, 2014.
APA
Moriya, H., Saito, K., Helsby, N., Sugino, S., Yamakage, M., Sawaguchi, T. ... Kurosawa, N. (2014). Association between the low‑dose irinotecan regimen‑induced occurrence of grade 4 neutropenia and genetic variants of UGT1A1 in patients with gynecological cancers. Oncology Letters, 7, 2035-2040. https://doi.org/10.3892/ol.2014.2046
MLA
Moriya, H., Saito, K., Helsby, N., Sugino, S., Yamakage, M., Sawaguchi, T., Takasaki, M., Kato, H., Kurosawa, N."Association between the low‑dose irinotecan regimen‑induced occurrence of grade 4 neutropenia and genetic variants of UGT1A1 in patients with gynecological cancers". Oncology Letters 7.6 (2014): 2035-2040.
Chicago
Moriya, H., Saito, K., Helsby, N., Sugino, S., Yamakage, M., Sawaguchi, T., Takasaki, M., Kato, H., Kurosawa, N."Association between the low‑dose irinotecan regimen‑induced occurrence of grade 4 neutropenia and genetic variants of UGT1A1 in patients with gynecological cancers". Oncology Letters 7, no. 6 (2014): 2035-2040. https://doi.org/10.3892/ol.2014.2046
Copy and paste a formatted citation
x
Spandidos Publications style
Moriya H, Saito K, Helsby N, Sugino S, Yamakage M, Sawaguchi T, Takasaki M, Kato H and Kurosawa N: Association between the low‑dose irinotecan regimen‑induced occurrence of grade 4 neutropenia and genetic variants of UGT1A1 in patients with gynecological cancers. Oncol Lett 7: 2035-2040, 2014.
APA
Moriya, H., Saito, K., Helsby, N., Sugino, S., Yamakage, M., Sawaguchi, T. ... Kurosawa, N. (2014). Association between the low‑dose irinotecan regimen‑induced occurrence of grade 4 neutropenia and genetic variants of UGT1A1 in patients with gynecological cancers. Oncology Letters, 7, 2035-2040. https://doi.org/10.3892/ol.2014.2046
MLA
Moriya, H., Saito, K., Helsby, N., Sugino, S., Yamakage, M., Sawaguchi, T., Takasaki, M., Kato, H., Kurosawa, N."Association between the low‑dose irinotecan regimen‑induced occurrence of grade 4 neutropenia and genetic variants of UGT1A1 in patients with gynecological cancers". Oncology Letters 7.6 (2014): 2035-2040.
Chicago
Moriya, H., Saito, K., Helsby, N., Sugino, S., Yamakage, M., Sawaguchi, T., Takasaki, M., Kato, H., Kurosawa, N."Association between the low‑dose irinotecan regimen‑induced occurrence of grade 4 neutropenia and genetic variants of UGT1A1 in patients with gynecological cancers". Oncology Letters 7, no. 6 (2014): 2035-2040. https://doi.org/10.3892/ol.2014.2046
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team