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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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July-2014 Volume 8 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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International Journal of Epigenetics

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Article

Predictive factor and antihypertensive usage of tyrosine kinase inhibitor‑induced hypertension in kidney cancer patients

  • Authors:
    • Kouji Izumi
    • Shingo Itai
    • Yoshiko Takahashi
    • Aerken Maolake
    • Mikio Namiki
  • View Affiliations / Copyright

    Affiliations: Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920‑8641, Japan, Department of Medicinal Informatics, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920‑8641, Japan
  • Pages: 305-308
    |
    Published online on: April 11, 2014
       https://doi.org/10.3892/ol.2014.2060
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Abstract

Hypertension (HT) is the common adverse event associated with vascular endothelial growth factor receptor‑tyrosine kinase inhibitors (VEGFR‑TKI). The present study was performed to identify the predictive factors of TKI‑induced HT and to determine the classes of antihypertensive agents (AHTA) that demonstrate optimal efficacy against this type of HT. The charts of 50 cases of patients that had received VEGFR‑TKI treatment were retrospectively examined. The association between patient background and TKI‑induced HT, and the effect of administering AHTA were analyzed. High systolic blood pressure at baseline was identified to be a predictive factor for HT. In addition, there was no difference observed between calcium channel blockers (CCBs) and angiotensin receptor II blockers (ARBs) as first‑line AHTA for the control of HT. The findings of the present study may aid with predicting the onset of TKI‑induced HT, as well as for its management via the primary use of either CCBs or ARBs.
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Copy and paste a formatted citation
Spandidos Publications style
Izumi K, Itai S, Takahashi Y, Maolake A and Namiki M: Predictive factor and antihypertensive usage of tyrosine kinase inhibitor‑induced hypertension in kidney cancer patients. Oncol Lett 8: 305-308, 2014.
APA
Izumi, K., Itai, S., Takahashi, Y., Maolake, A., & Namiki, M. (2014). Predictive factor and antihypertensive usage of tyrosine kinase inhibitor‑induced hypertension in kidney cancer patients. Oncology Letters, 8, 305-308. https://doi.org/10.3892/ol.2014.2060
MLA
Izumi, K., Itai, S., Takahashi, Y., Maolake, A., Namiki, M."Predictive factor and antihypertensive usage of tyrosine kinase inhibitor‑induced hypertension in kidney cancer patients". Oncology Letters 8.1 (2014): 305-308.
Chicago
Izumi, K., Itai, S., Takahashi, Y., Maolake, A., Namiki, M."Predictive factor and antihypertensive usage of tyrosine kinase inhibitor‑induced hypertension in kidney cancer patients". Oncology Letters 8, no. 1 (2014): 305-308. https://doi.org/10.3892/ol.2014.2060
Copy and paste a formatted citation
x
Spandidos Publications style
Izumi K, Itai S, Takahashi Y, Maolake A and Namiki M: Predictive factor and antihypertensive usage of tyrosine kinase inhibitor‑induced hypertension in kidney cancer patients. Oncol Lett 8: 305-308, 2014.
APA
Izumi, K., Itai, S., Takahashi, Y., Maolake, A., & Namiki, M. (2014). Predictive factor and antihypertensive usage of tyrosine kinase inhibitor‑induced hypertension in kidney cancer patients. Oncology Letters, 8, 305-308. https://doi.org/10.3892/ol.2014.2060
MLA
Izumi, K., Itai, S., Takahashi, Y., Maolake, A., Namiki, M."Predictive factor and antihypertensive usage of tyrosine kinase inhibitor‑induced hypertension in kidney cancer patients". Oncology Letters 8.1 (2014): 305-308.
Chicago
Izumi, K., Itai, S., Takahashi, Y., Maolake, A., Namiki, M."Predictive factor and antihypertensive usage of tyrosine kinase inhibitor‑induced hypertension in kidney cancer patients". Oncology Letters 8, no. 1 (2014): 305-308. https://doi.org/10.3892/ol.2014.2060
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