Effect of interleukin 21 and its receptor on CD8+ T cells in the pathogenesis of diffuse large B‑cell lymphoma

Cha,Zhanshan; Gu,Haihui; Guo,Huijun; Tu,Xiaohua; Zang,Yan; Zhao,Chunyan; Hua,Meixian; Rechlic,James R.; Olasnova,Lindsay M.; Song,Haihan; Qian,Baohua

doi:10.3892/ol.2014.2062

July-2014 Volume 8 Issue 1

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July-2014 Volume 8 Issue 1

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Article

Effect of interleukin 21 and its receptor on CD8+ T cells in the pathogenesis of diffuse large B‑cell lymphoma

Authors:
- Zhanshan Cha
- Haihui Gu
- Huijun Guo
- Xiaohua Tu
- Yan Zang
- Chunyan Zhao
- Meixian Hua
- James R. Rechlic
- Lindsay M. Olasnova
- Haihan Song
- Baohua Qian
View Affiliations / Copyright

Affiliations: Department of Transfusion, Changhai Hospital, Second Military Medical University, Shanghai 200433, P.R. China, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA, Department of Internal Medicine, Emergency Center, East Hospital, Tongji University School of Medicine, Shanghai 200120, P.R. China
Pages: 421-425
|
Published online on: April 11, 2014

https://doi.org/10.3892/ol.2014.2062
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Abstract

Interleukin 21 (IL‑21) and its receptor, IL‑21R, play a key role in innate and adaptive immunity. In the present study, the effect of IL‑21 and IL‑21R on the pathogenesis of diffuse large B‑cell lymphoma (DLBCL) was investigated. The serum levels of IL‑21 were detected by enzyme‑linked immunosorbent assay, and the expression of IL‑21R on CD8+ T cells was examined through flow cytometry. The data showed that the serum level of IL‑21 was significantly decreased in the patients with DLBCL compared with the healthy controls (P<0.001), whereas the expression of IL‑21R was clearly elevated on the CD8+ T cells in the patients with DLBCL. Further analyses revealed that the downregulation of the IL‑21 serum level was correlated with an increased tumor stage of DLBCL, while the expression of IL‑21R on the CD8+ T cells was positively correlated with the tumor stage. Also, the serum level of IL‑21 and the proportion of IL‑21R on the CD8+ T cells were negatively correlated in the patients. Notably, it was identified that the proportion of IL‑21R on the CD8+ T cells, but not the serum level of IL‑21, was significantly upregulated in the patients with bone‑marrow involvement and B symptoms. These results indicate that IL‑21 and IL‑21R may be involved in the pathogenesis of DLBCL, in which IL‑21R may reflect the progression of the disease more accurately than the serum level of IL‑21.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Effect of interleukin 21 and its receptor on CD8+ T cells in the pathogenesis of diffuse large B‑cell lymphoma

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