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Article

Angiopoietin‑like 4 promotes melanoma cell invasion and survival through aldolase A

  • Authors:
    • Yang Sun
    • Jianhong Long
    • Yu Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Plastic and Aesthetic Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China, Department of Orthopaedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China
  • Pages: 211-217
    |
    Published online on: April 16, 2014
       https://doi.org/10.3892/ol.2014.2071
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Abstract

In the present study, the association between angiopoietin‑like 4 (ANGPTL4) and aldolase A (ALDOA) in human melanoma cell invasion and survival was investigated. Overexpression and knockdown of ANGPTL4 were respectively performed in WM‑115 and WM‑266‑4 cells. ALDOA expression at both the mRNA and the protein levels as well as the ALDOA gene promoter activities were increased and decreased in parallel with overexpression and knockdown of ANGPTL4 in the melanoma cells, which was blocked by selective protein kinase C (PKC) inhibitor and restored by PKC agonist, respectively. ANGPTL4 overexpression significantly increased cell invasion and matrix metalloproteinase‑2 (MMP‑2) expression and decreased cell apoptosis against cisplatin in WM‑115 cells, which was reversed by knocking down ALDOA. In WM‑266‑4 cells, knockdown of ANGPTL4 decreased cell invasion and MMP‑2 expression and increased cell apoptosis against cisplatin, which was reversed by overexpression of ALDOA. In conclusion, this study demonstrates that ANGPTL4 upregulates ALDOA expression in human melanoma cells at the ALDOA gene promoter/transcriptional level through a PKC‑dependent mechanism, and that ALDOA is a critical mediator of the promoting effect of ANGPTL4 on melanoma cell invasion, likely through upregulating the MMP‑2 expression. Additionally, our results suggest that ALDOA plays an important role in ANGPTL4‑enhanced melanoma cell survival against apoptotic stress, which implicates ANGPTL4 and ALDOA in the development of melanoma chemoresistance.
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1 

Schwartz D and Beitner R: Detachment of the glycolytic enzymes, phosphofructokinase and aldolase, from cytoskeleton of melanoma cells, induced by local anesthetics. Mol Genet Metab. 69:159–164. 2000.

2 

Scatena R, Bottoni P, Pontoglio A, Mastrototaro L and Giardina B: Glycolytic enzyme inhibitors in cancer treatment. Expert Opin Investig Drugs. 17:1533–1545. 2008.

3 

Marin-Hernández A, Rodríguez-Enríquez S, Vital-González PA, Flores-Rodríguez FL, Macías-Silva M, Sosa-Garrocho M and Moreno-Sánchez R: Determining and understanding the control of glycolysis in fast-growth tumor cells. Flux control by an over-expressed but strongly product-inhibited hexokinase. FEBS J. 273:1975–1988. 2006.

4 

Mandard S, Zandbergen F, van Straten E, Wahli W, Kuipers F, Muller M and Kersten S: The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity. J Biol Chem. 281:934–944. 2006.

5 

Yoshida K, Shimizugawa T, Ono M and Furukawa H: Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase. J Lipid Res. 43:1770–1772. 2002.

6 

Xu A, Lam MC, Chan KW, et al: Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice. Proc Natl Acad Sci USA. 102:6086–6091. 2005.

7 

Lal A, Peters H, St Croix B, et al: Transcriptional response to hypoxia in human tumors. J Natl Cancer Inst. 93:1337–1343. 2001.

8 

Le Jan S, Amy C, Cazes A, et al: Angiopoietin-like 4 is a proangiogenic factor produced during ischemia and in conventional renal cell carcinoma. Am J Pathol. 162:1521–1528. 2003.

9 

Izraely S, Sagi-Assif O, Klein A, et al: The metastatic microenvironment: brain-residing melanoma metastasis and dormant micrometastasis. Int J Cancer. 131:1071–1082. 2012.

10 

Sakakibara M, Takahashi I, Takasaki Y, Mukai T and Hori K: Construction and expression of human aldolase A and B expression plasmids in Escherichia coli host. Biochim Biophys Acta. 1007:334–342. 1989.

11 

Pal M, Tan MJ, Huang RL, Goh YY, Wang XL, Tang MB and Tan NS: Angiopoietin-like 4 regulates epidermal differentiation. PLoS One. 6:e253772011.

12 

Costanzo P, Lupo A, Medugno L, D’Agostino P, Zevino C and Izzo P: PKC-dependent phosphorylation of the p97 repressor regulates the transcription of aldolase A L-type promoter. FEBS Lett. 454:61–66. 1999.

13 

Stapleton CM, Joo JH, Kim YS, Liao G, Panettieri RA Jr and Jetten AM: Induction of ANGPTL4 expression in human airway smooth muscle cells by PMA through activation of PKC and MAPK pathways. Exp Cell Res. 316:507–516. 2010.

14 

Wu H, Yang L, Liao D, Chen Y, Wang W and Fang J: Podocalyxin regulates astrocytoma cell invasion and survival against temozolomide. Exp Ther Med. 5:1025–1029. 2013.

15 

Chen X, Yang TT, Zhou Y, et al: Proteomic profiling of osteosarcoma cells identifies ALDOA and SULT1A3 as negative survival markers of human osteosarcoma. Mol Carcinog. 53:138–144. 2014.

16 

Peng SY, Lai PL, Pan HW, Hsiao LP and Hsu HC: Aberrant expression of the glycolytic enzymes aldolase B and type II hexokinase in hepatocellular carcinoma are predictive markers for advanced stage, early recurrence and poor prognosis. Oncol Rep. 19:1045–1053. 2008.

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Copy and paste a formatted citation
Spandidos Publications style
Sun Y, Long J and Zhou Y: Angiopoietin‑like 4 promotes melanoma cell invasion and survival through aldolase A. Oncol Lett 8: 211-217, 2014.
APA
Sun, Y., Long, J., & Zhou, Y. (2014). Angiopoietin‑like 4 promotes melanoma cell invasion and survival through aldolase A. Oncology Letters, 8, 211-217. https://doi.org/10.3892/ol.2014.2071
MLA
Sun, Y., Long, J., Zhou, Y."Angiopoietin‑like 4 promotes melanoma cell invasion and survival through aldolase A". Oncology Letters 8.1 (2014): 211-217.
Chicago
Sun, Y., Long, J., Zhou, Y."Angiopoietin‑like 4 promotes melanoma cell invasion and survival through aldolase A". Oncology Letters 8, no. 1 (2014): 211-217. https://doi.org/10.3892/ol.2014.2071
Copy and paste a formatted citation
x
Spandidos Publications style
Sun Y, Long J and Zhou Y: Angiopoietin‑like 4 promotes melanoma cell invasion and survival through aldolase A. Oncol Lett 8: 211-217, 2014.
APA
Sun, Y., Long, J., & Zhou, Y. (2014). Angiopoietin‑like 4 promotes melanoma cell invasion and survival through aldolase A. Oncology Letters, 8, 211-217. https://doi.org/10.3892/ol.2014.2071
MLA
Sun, Y., Long, J., Zhou, Y."Angiopoietin‑like 4 promotes melanoma cell invasion and survival through aldolase A". Oncology Letters 8.1 (2014): 211-217.
Chicago
Sun, Y., Long, J., Zhou, Y."Angiopoietin‑like 4 promotes melanoma cell invasion and survival through aldolase A". Oncology Letters 8, no. 1 (2014): 211-217. https://doi.org/10.3892/ol.2014.2071
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