Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
July-2014 Volume 8 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2014 Volume 8 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Diagnosis and microsurgical treatment of chondromas and chondrosarcomas of the cranial base

  • Authors:
    • Sumin Geng
    • Junting Zhang
    • Li‑Wei Zhang
    • Zhen Wu
    • Guijun Jia
    • Xinru Xiao
    • Shuyu Hao
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Beijing Tiantan Hospital of Capital Medical University, Beijing 100050, P.R. China
  • Pages: 301-304
    |
    Published online on: April 16, 2014
       https://doi.org/10.3892/ol.2014.2072
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Chondromas and chondrosarcomas of the cranial base are rare neoplastic diseases. The aim of the present study was to evaluate the diagnosis and microsurgical treatment of these difficult cranial base tumors. A total of 19 patients who underwent microsurgery were pathologically diagnosed with cranial base chondromas or chondrosarcomas and their clinical data was reviewed. The chondromas and chondrosarcomas of the cranial base in the present study commonly originated in the sphenopetrosal, sphenoclival or petroclival junctions, and the majority were located in the parasellar region of the middle cranial base extradurally. The most frequent symptoms were headaches and cranial nerve palsy, and the Karnofsky performance score (KPS), assessed pre‑operatively, averaged at 87.1. A frontotemporal or preauricular subtemporal‑infratemporal approach was used in 11 cases, a tempo‑occipital transtentorial or presigmoid supratentorial‑infratentorial approach was employed in six further cases, and the far‑lateral or retrosigmoid approach was applied in the remaining two cases. A total or near‑total tumor removal was secured in 13 cases, while a subtotal removal was obtained in another five and a partial removal was achieved in one case. The most common post‑operative complications included cranial nerve palsy and cerebrospinal fluid leakage, but there were no post‑operative fatalities. A total of 15 patients were followed up for a mean of 67.2 months (range, 5‑140 months), and 13 (76.5%) of these patients were living normal lives (KPS, 80‑90). There were two patients with recurrent tumors. The neuroradiological examinations and the presenting symptoms and signs allow the pre‑operative diagnosis to be presumed for the majority of cranial base chondromas or chondrosarcomas. Surgical resection is the key treatment for these tumors, and this treatment is known to improve the survival rates.
View Figures

Figure 1

Figure 2

View References

1 

Bloch OG, Jian BJ, Yang I, Han SJ, Aranda D, Ahn BJ and Parsa AT: A systematic review of intracranial chondrosarcoma and survival. J Clin Neurosci. 16:1547–1551. 2009.

2 

Bloch OB, Jian BJ, Yang I, Han SJ, Aranda D, Ahn BJ and Parsa AT: Cranial chondrosarcoma and recurrence. Skull Base. 20:149–156. 2010.

3 

Knott PD, Gannon FH and Thompson LD: Mesenchymal chondrosarcoma of the sinonasal tract: a clinicopathological study of 13 cases with a review of the literature. Laryngoscope. 113:783–790. 2003.

4 

Scheithauer BW and Rubinstein LJ: Meningeal mesenchymal chondrosarcoma: report of eight cases with review of literature. Cancer. 42:2744–2752. 1978.

5 

Heffelfinger MJ, Dahlin DC, MacCarty CS and Beabout JW: Chordomas and cartilaginous tumors at the skull base. Cancer. 32:410–420. 1973.

6 

Gay E, Sekhar LN, Rubinstein E, Wright DC, Sen C, Janecka IP and Snyderman CH: Chordomas and chondrosarcomas of the cranial base: results and follow up of 60 cases. Neurosurgery. 36:887–897. 1995.

7 

Neff B, Sataloff RT, Storey L, Hawkshaw M and Spiegel JR: Chondrosarcoma of the skull base. Laryngoscope. 112:134–139. 2002.

8 

Launay M, Fredy D, Merland JJ and Bories J: Narrowing and occlusion of arteries by intracranial tumors. Review of the literature and report of 25 cases. Neuroradiology. 14:117–126. 1977.

9 

Geibprasert S, Pongpech S, Armstrong D and Krings T: Dangerous extracranial-intracranial anastomoses and supply to the cranial nerves: vessels the neurointerventionalist needs to know. AJNR Am J Neuroradiol. 30:1459–1468. 2009.

10 

Traflet RF, Babaria AR, Barolat G, Doan HT, Gonzalez C and Mishkin MM: Intracranial chondroma in a patient with Ollier’s disease: Case report. J Neurosurg. 70:274–276. 1989.

11 

Noël G, Feuvret L, Calugaru V, Hadadi K, Baillet F, Mazeron JJ and Habrand JL: Chondrosarcomas of the base of the skull in Ollier’s disease or Maffucci’s syndrome - three case reports and review of the literature. Acta Oncol. 43:705–710. 2004.

12 

Seizeur R, Forlodou P, Quintin-Roue I, Person H and Besson G: Chondrosarcoma of the skull base in Maffucci’s syndrome. Br J Neurosurg. 22:778–780. 2008.

13 

Tibbs RE Jr and Bowles AP Jr: Maffucci’s syndrome associated with a cranial base chondrosarcoma: case report and literature review. Neurosurgery. 43:3971998.

14 

Tachibana E, Saito K, Takahashi M, Fukuta K and Yoshida J: Surgical treatment of a massive chondrosarcoma in the skull base associated with Maffucci’s syndrome: a case report. Surg Neurol. 54:165–170. 2000.

15 

Ramina R, Coelho Neto M, Meneses MS and Pedrozo AA: Maffucci’s syndrome associated with a cranial base chondrosarcoma: case report and literature review. Neurosurgery. 41:269–272. 1997.

16 

Nakayama Y, Takeno Y, Tsugu H and Tomonaga M: Maffucci’s syndrome associated with intracranial chordoma: case report. Neurosurgery. 34:907–909. 1994.

17 

Korten AG, ter Berg HJ, Spincemaille GH, van der Laan RT and Van de Wel AM: Intracranial chondrosarcoma: review of the literature and report of 15 cases. J Neurol Neurosurg Psychiatry. 65:88–92. 1998.

18 

Lanzino G, Dumont AS, Lopes MS and Laws ER Jr: Skull base chordomas: overview of disease, management options, and outcome. Neurosurg Focus. 10:E122001.

19 

Tzortzidis F, Elahi F, Wright DC, Temkin N, Natarajan SK and Sekhar LN: Patient outcome at long-term follow-up after aggressive microsurgical resection of cranial base chondrosarcomas. Neurosurgery. 58:1090–1098. 2006.

20 

Kondziolka D, Lunsford LD and Flickinger JC: The role of radiosurgery in the management of chordoma and chondrosarcoma of the cranial base. Neurosurgery. 29:38–46. 1991.

21 

Krishnan S, Foote RL, Brown PD, Pollock BE, Link MJ and Garces YI: Radiosurgery for cranial base chordomas and chondrosarcomas. Neurosurgery. 56:777–784. 2005.

22 

Hug EB, Loredo LN, Slater JD, DeVries A, Grove RI, Schaefer RA, Rosenberg AE and Slater JM: Proton radiation therapy for chordomas and chondrosarcomas of the skull base. J Neurosurg. 91:432–439. 1999.

23 

Hug EB and Slater JD: Proton radiation therapy for chordomas and chondrosarcomas of the skull base. Neurosurg Clin N Am. 11:627–638. 2000.

24 

Amichetti M, Amelio D, Cianchetti M, Maurizi Enrici R and Minniti G: A systematic review of proton therapy in the treatment of chondrosarcoma of the skull base. Neurosurg Rev. 33:155–165. 2010.

25 

Muthukumar N, Kondziolka D, Lunsford LD and Flickinger JC: Stereotactic radiosurgery for chordoma and chondrosarcoma: further experiences. Int J Radiat Oncol Biol Phys. 41:387–392. 1998.

26 

Oghalai JS, Buxbaum JL, Jackler RK and McDermott MW: Skull base chondrosarcoma originating from the petroclival junction. Otol Neurotol. 26:1052–1060. 2005.

27 

Förander P, Rähn T, Kihlström L, Ulfarsson E and Mathiesen T: Combination of microsurgery and gamma knife surgery for the treatment of intracranial chondrosarcomas. J Neurosurg. 105(Suppl): 18–25. 2006.

28 

Crockard HA, Cheeseman A, Steel T, Revesz T, Holton JL, Plowman N, Singh A and Crossman J: A multidisciplinary team approach to skull base chondrosarcomas. J Neurosurg. 95:184–189. 2001.

29 

Samii A, Gerganov V, Herold C, Gharabaghi A, Hayashi N and Samii M: Surgical treatment of skull base chondrosarcomas. Neurosurg Rev. 32:67–75. 2009.

30 

Sekhar LN, Pranatartiharan R, Chanda A and Wright DC: Chordomas and chondrosarcomas of the skull base: results and complications of surgical management. Neurosurg Focus. 10:E22001.

31 

Wanebo JE, Bristol RE, Porter RR, Coons SW and Spetzler RF: Management of cranial base chondrosarcomas. Neurosurgery. 58:249–255. 2006.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Geng S, Zhang J, Zhang LW, Wu Z, Jia G, Xiao X and Hao S: Diagnosis and microsurgical treatment of chondromas and chondrosarcomas of the cranial base. Oncol Lett 8: 301-304, 2014.
APA
Geng, S., Zhang, J., Zhang, L., Wu, Z., Jia, G., Xiao, X., & Hao, S. (2014). Diagnosis and microsurgical treatment of chondromas and chondrosarcomas of the cranial base. Oncology Letters, 8, 301-304. https://doi.org/10.3892/ol.2014.2072
MLA
Geng, S., Zhang, J., Zhang, L., Wu, Z., Jia, G., Xiao, X., Hao, S."Diagnosis and microsurgical treatment of chondromas and chondrosarcomas of the cranial base". Oncology Letters 8.1 (2014): 301-304.
Chicago
Geng, S., Zhang, J., Zhang, L., Wu, Z., Jia, G., Xiao, X., Hao, S."Diagnosis and microsurgical treatment of chondromas and chondrosarcomas of the cranial base". Oncology Letters 8, no. 1 (2014): 301-304. https://doi.org/10.3892/ol.2014.2072
Copy and paste a formatted citation
x
Spandidos Publications style
Geng S, Zhang J, Zhang LW, Wu Z, Jia G, Xiao X and Hao S: Diagnosis and microsurgical treatment of chondromas and chondrosarcomas of the cranial base. Oncol Lett 8: 301-304, 2014.
APA
Geng, S., Zhang, J., Zhang, L., Wu, Z., Jia, G., Xiao, X., & Hao, S. (2014). Diagnosis and microsurgical treatment of chondromas and chondrosarcomas of the cranial base. Oncology Letters, 8, 301-304. https://doi.org/10.3892/ol.2014.2072
MLA
Geng, S., Zhang, J., Zhang, L., Wu, Z., Jia, G., Xiao, X., Hao, S."Diagnosis and microsurgical treatment of chondromas and chondrosarcomas of the cranial base". Oncology Letters 8.1 (2014): 301-304.
Chicago
Geng, S., Zhang, J., Zhang, L., Wu, Z., Jia, G., Xiao, X., Hao, S."Diagnosis and microsurgical treatment of chondromas and chondrosarcomas of the cranial base". Oncology Letters 8, no. 1 (2014): 301-304. https://doi.org/10.3892/ol.2014.2072
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team