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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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July-2014 Volume 8 Issue 1

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Case Report

Malignant transformation of fibrous dysplasia: A case report

  • Authors:
    • Hiroshi Hatano
    • Tetsuro Morita
    • Takashi Ariizumi
    • Hiroyuki Kawashima
    • Akira Ogose
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedic Surgery, Niigata Cancer Center Hospital, Niigata 951‑8566, Japan, Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951‑8510, Japan
  • Pages: 384-386
    |
    Published online on: April 22, 2014
       https://doi.org/10.3892/ol.2014.2082
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Abstract

Secondary osteosarcoma from fibrous dysplasia (FD) is very rare. The etiology of FD is linked to activating missense mutations of the guanine nucleotide‑binding protein α‑subunit (GNAS) gene, which encodes the stimulatory α subunit of the G protein (Gsα) and is located at chromosome 20q13. These mutations are central to the pathogenesis of FD; however, it is not known whether Gsα mutations are retained following malignant transformation in FD. In addition, to the best of our knowledge, no studies have been performed on chromosomal analysis of secondary osteosarcoma from FD. The present study presents a case of secondary osteosarcoma arising from polyostotic FD in a 72‑year‑old male. Chromosomal analysis showed 44, X, ‑Y, add(4)(p11), add(5)(p15), der(11)add(11)(p15)t(1;11)(q21;q23), add(12)(q11), ‑13, der(22)t(12;22)(q11;p12). Reverse transcription‑polymerase chain reaction (RT‑PCR) analysis demonstrated the presence of a Gsα mutation in both the primary tumor cells and secondary osteosarcoma cells. There was no alteration in this mutation in the region of malignant transformation, which suggests that this mutation may be a useful clinical marker for distinguishing de novo osteosarcoma (primary osteosarcoma) from secondary osteosarcoma arising from FD.
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Copy and paste a formatted citation
Spandidos Publications style
Hatano H, Morita T, Ariizumi T, Kawashima H and Ogose A: Malignant transformation of fibrous dysplasia: A case report. Oncol Lett 8: 384-386, 2014.
APA
Hatano, H., Morita, T., Ariizumi, T., Kawashima, H., & Ogose, A. (2014). Malignant transformation of fibrous dysplasia: A case report. Oncology Letters, 8, 384-386. https://doi.org/10.3892/ol.2014.2082
MLA
Hatano, H., Morita, T., Ariizumi, T., Kawashima, H., Ogose, A."Malignant transformation of fibrous dysplasia: A case report". Oncology Letters 8.1 (2014): 384-386.
Chicago
Hatano, H., Morita, T., Ariizumi, T., Kawashima, H., Ogose, A."Malignant transformation of fibrous dysplasia: A case report". Oncology Letters 8, no. 1 (2014): 384-386. https://doi.org/10.3892/ol.2014.2082
Copy and paste a formatted citation
x
Spandidos Publications style
Hatano H, Morita T, Ariizumi T, Kawashima H and Ogose A: Malignant transformation of fibrous dysplasia: A case report. Oncol Lett 8: 384-386, 2014.
APA
Hatano, H., Morita, T., Ariizumi, T., Kawashima, H., & Ogose, A. (2014). Malignant transformation of fibrous dysplasia: A case report. Oncology Letters, 8, 384-386. https://doi.org/10.3892/ol.2014.2082
MLA
Hatano, H., Morita, T., Ariizumi, T., Kawashima, H., Ogose, A."Malignant transformation of fibrous dysplasia: A case report". Oncology Letters 8.1 (2014): 384-386.
Chicago
Hatano, H., Morita, T., Ariizumi, T., Kawashima, H., Ogose, A."Malignant transformation of fibrous dysplasia: A case report". Oncology Letters 8, no. 1 (2014): 384-386. https://doi.org/10.3892/ol.2014.2082
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