Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
July-2014 Volume 8 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2014 Volume 8 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

SKI‑II reverses the chemoresistance of SGC7901/DDP gastric cancer cells

  • Authors:
    • Ying Liu
    • Zuan Zhu
    • Hongxing Cai
    • Qinghua Liu
    • Honglian Zhou
    • Zhengqiu Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Xuzhou Medical College, Xuzhou, Jiangsu 221002, P.R. China, Department of Gastroenterology, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu 221002, P.R. China, Department of Forensic Medicine, Xuzhou Medical College, Xuzhou, Jiangsu 221002, P.R. China, Department of Medical Oncology, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu 221002, P.R. China
  • Pages: 367-373
    |
    Published online on: April 25, 2014
       https://doi.org/10.3892/ol.2014.2083
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Cisplatin is frequently used in treating gastric cancers; however, acquired resistance to the drug often reduces the efficacy of therapy. The present study analyzed the efficacy of the combination of 4‑[4‑(4‑chloro‑phenyl)‑thiazol‑2‑ylamino]-phenol (SKI‑Ⅱ) and cisplatin [cis‑diamminedichloroplatinum (II); DDP] on the gastric cancer SGC7901/DDP cell line. The results revealed that SKI‑Ⅱ and DDP had a clear synergistic effect. Glutathione (GSH) and glutathione S‑transferase (GST) levels decreased significantly subsequent to the cells being treated with the combination of DDP and SKI‑Ⅱ compared with the cells that were treated with DDP or SKI‑Ⅱ alone. Phosphorylated extracellular-signal-regulated kinase (p‑ERK) and phosphorylated c-Jun N-terminal kinase (p‑JNK) expression levels also decreased following treatment with SKI‑Ⅱ. The results suggested that SKI‑Ⅱ is able to reverse the drug resistance in human gastric carcinoma cells and enhance the antitumor effect of DDP through the ras/mitogen‑activated protein kinase (MAPK) proliferation pathway.
View Figures

Figure 1

View References

1 

Lekakis L, Tryfonopoulos D, Pistamatzian N, et al: Salvage chemotherapy with cisplatin and 5-fluorouracil in metastatic breast cancer. Particular activity against liver metastases. Anticancer Res. 32:1833–1837. 2012.

2 

García-Velasco A, Durán I, García E, et al: Biological markers of cisplatin resistance in advanced testicular germ cell tumours. Clin Transl Oncol. 14:452–457. 2012.

3 

Yanagawa M, Tatsumi M, Miyata H, et al: Evaluation of response to neoadjuvant chemotherapy for esophageal cancer: PET response criteria in solid tumors versus response evaluation criteria in solid tumors. J Nucl Med. 53:872–880. 2012.

4 

Kumar A and Saba JD: Lyase to live by: sphingosine phosphate lyase as a therapeutic target. Expert Opin Ther Targets. 13:1013–1025. 2009.

5 

Hla T: Physiological and pathological actions of sphingosine 1-phosphate. Semin Cell Dev Biol. 15:513–520. 2004.

6 

Ogretmen B and Hannun YA: Biologically active sphingolipids in cancer pathogenesis and treatment. Nat Rev Cancer. 4:604–616. 2004.

7 

Spiegel S and Milstien S: Sphingosine 1-phosphate, a key cell signaling molecule. J Biol Chem. 277:25851–25854. 2002.

8 

Taha TA, Argraves KM and Obeid LM: Sphingosine-1-phosphate receptors: receptor specificity versus functional redundancy. Biochim Biophys Acta. 1682:48–55. 2004.

9 

Kumar A, Wessels D, Daniels KJ, et al: Sphingosine-1-phosphate plays a role in the suppression of lateral pseudopod formation during Dictyostelium discoideum cell migration and chemotaxis. Cell Motil Cytoskeleton. 59:227–241. 2004.

10 

Oskouian B and Saba JD: Death and taxis: what non-mammalian models tell us about sphingosine-1-phosphate. Semin Cell Dev Biol. 15:529–540. 2004.

11 

Spiegel S, English D and Milstien S: Sphingosine 1-phosphate signaling: providing cells with a sense of direction. Trends Cell Biol. 12:236–242. 2002.

12 

French KJ, Upson JJ, Keller SN, et al: Antitumor activity of sphingosine kinase inhibitors. J Pharmacol Exp Ther. 318:596–603. 2006.

13 

Roukos DH and Kappas AM: Perspectives in the treatment of gastric cancer. Nat Clin Pract Oncol. 2:98–107. 2005.

14 

Menges M, Schmidt C, Lindemann W, et al: Low toxic neoadjuvant cisplatin, 5-fluorouracil and folinic acid in locally advanced gastric cancer yields high R-0 resection rate. J Cancer Res Clin Oncol. 129:423–429. 2003.

15 

Zhao Z, Wang J, Tang J, et al: JNK-and Akt-mediated Puma expression in the apoptosis of cisplatin-resistant ovarian cancer cells. Biochem J. 444:291–301. 2012.

16 

Hasegawa M, Ishiguro K, Ando T and Goto H: Geranylgeranylacetone attenuates cisplatin-induced reductions in cell viability by suppressing the elevation of intracellular p53 content without heat shock protein induction. Nagoya J Med Sci. 74:123–131. 2012.

17 

Vasconcelos FC, Cavalcanti GB Jr, Silva KL, et al: Constrasting features of MDR phenotype in leukemias by using two fluorochromes: implications for clinical practice. Leuk Res. 31:445–454. 2007.

18 

Patel NH and Rothenberg ML: Multidrug resistance in cancer chemotherapy. Invest New Drugs. 12:1–13. 1994.

19 

Legrand O, Simonin G, Beauchamp-Nicoud A, et al: Simultaneous activity of MRP1 and Pgp is correlated with in vitro resistance to daunorubicin and with in vivo resistance in adult acute myeloid leukemia. Blood. 94:1046–1056. 1999.

20 

Valko M, Rhodes CJ, Moncol J, et al: Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact. 160:1–40. 2006.

21 

Cobb MH and Goldsmith EJ: How MAP kinases are regulated. J Biol Chem. 270:14843–14846. 1995.

22 

Wagner EF and Nebreda AR: Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer. 9:537–549. 2009.

23 

Lee HG, Minematsu H, Kim KO, et al: Actin and ERK1/2-CEBPβ signaling mediates phagocytosis-induced innate immune response of osteoprogenitor cells. Biomaterials. 32:9197–9206. 2011.

24 

McGlynn LM, Kirkegaard T, Edwards J, et al: Ras/Raf-1/MAPK pathway mediates response to tamoxifen but not chemotherapy in breast cancer patients. Clin Cancer Res. 15:1487–1495. 2009.

25 

Atmaca A, Pauligk C, Steinmetz K, et al: Prognostic impact of phosphorylated mitogen-activated protein kinase expression in patients with metastatic gastric cancer. Oncology. 80:130–134. 2011.

26 

Wasserman WW and Fahl WE: Functional antioxidant responsive elements. Proc Natl Acad Sci USA. 94:5361–5366. 1997.

27 

Li Y and Jaiswal AK: Regulation of human NAD(P)H: quinone oxidoreductase gene. Role of AP1 binding site contained within human antioxidant response element. J Biol Chem. 267:15097–15104. 1992.

28 

Rushmore TH and Pickett CB: Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants. J Biol Chem. 265:14648–14653. 1990.

29 

Prestera T, Holtzclaw WD, Zhang Y and Talalay P: Chemical and molecular regulation of enzymes that detoxify carcinogens. Proc Natl Acad Sci USA. 90:2965–2969. 1993.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu Y, Zhu Z, Cai H, Liu Q, Zhou H and Zhu Z: SKI‑II reverses the chemoresistance of SGC7901/DDP gastric cancer cells. Oncol Lett 8: 367-373, 2014.
APA
Liu, Y., Zhu, Z., Cai, H., Liu, Q., Zhou, H., & Zhu, Z. (2014). SKI‑II reverses the chemoresistance of SGC7901/DDP gastric cancer cells. Oncology Letters, 8, 367-373. https://doi.org/10.3892/ol.2014.2083
MLA
Liu, Y., Zhu, Z., Cai, H., Liu, Q., Zhou, H., Zhu, Z."SKI‑II reverses the chemoresistance of SGC7901/DDP gastric cancer cells". Oncology Letters 8.1 (2014): 367-373.
Chicago
Liu, Y., Zhu, Z., Cai, H., Liu, Q., Zhou, H., Zhu, Z."SKI‑II reverses the chemoresistance of SGC7901/DDP gastric cancer cells". Oncology Letters 8, no. 1 (2014): 367-373. https://doi.org/10.3892/ol.2014.2083
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Y, Zhu Z, Cai H, Liu Q, Zhou H and Zhu Z: SKI‑II reverses the chemoresistance of SGC7901/DDP gastric cancer cells. Oncol Lett 8: 367-373, 2014.
APA
Liu, Y., Zhu, Z., Cai, H., Liu, Q., Zhou, H., & Zhu, Z. (2014). SKI‑II reverses the chemoresistance of SGC7901/DDP gastric cancer cells. Oncology Letters, 8, 367-373. https://doi.org/10.3892/ol.2014.2083
MLA
Liu, Y., Zhu, Z., Cai, H., Liu, Q., Zhou, H., Zhu, Z."SKI‑II reverses the chemoresistance of SGC7901/DDP gastric cancer cells". Oncology Letters 8.1 (2014): 367-373.
Chicago
Liu, Y., Zhu, Z., Cai, H., Liu, Q., Zhou, H., Zhu, Z."SKI‑II reverses the chemoresistance of SGC7901/DDP gastric cancer cells". Oncology Letters 8, no. 1 (2014): 367-373. https://doi.org/10.3892/ol.2014.2083
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team