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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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July-2014 Volume 8 Issue 1

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International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Case Report

Combined chemotherapy plus endostar with sequential stereotactic radiotherapy as salvage treatment for recurrent esophageal cancer with severe dyspnea: A case report and review of the literature

  • Authors:
    • Mingfang Xu
    • Huan Huang
    • Yanli Xiong
    • Bo Peng
    • Zejun Zhou
    • Dong Wang
    • Xueqin Yang
  • View Affiliations / Copyright

    Affiliations: Cancer Center, Daping Hospital, Third Military Medical University, Chongqing 400042, P.R. China
  • Pages: 291-294
    |
    Published online on: April 25, 2014
       https://doi.org/10.3892/ol.2014.2087
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Abstract

For the majority of inoperable esophageal cancer cases, chemoradiotherapy is the most suitable treatment option. Cetuximab may provide certain benefits, however, this can be an expensive therapy. Additionally, stereotactic body radiation therapy (SBRT) is typically contraindicated for esophageal cancer due to the potential for esophageal perforation and stenosis. The use of combined chemotherapy plus endostar with sequential SBRT for the treatment of esophageal squamous cancer has not been reported. In the current study, the case of a 71‑year‑old female with esophageal squamous cancer diagnosed 2 years prior is presented. Surgery and four cycles of cisplatin plus 5‑fluorouracil chemotherapy had been administered. The patient showed recurrence at the paratracheal lymph node, exhibited severe dyspnea (grade III) and required a semi‑liquid diet. Four cycles of the docetaxel, 5‑fluorouracil and nedaplatin regimen plus endostar (3 mg; days 1‑14; intravenously) with sequential SBRT (3300 cGy in 10 fractions) was administered. Following treatment, the symptoms of the patient completely disappeared, and objective efficacy evaluation indicated complete remission. At the time of writing, the patient is living without discomfort and the progression‑free survival is >8 months. In conclusion, the present case indicates that combined treatment of chemotherapy and endostar with sequential stereotactic radiotherapy is a safe and effective option for the management of esophageal cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Xu M, Huang H, Xiong Y, Peng B, Zhou Z, Wang D and Yang X: Combined chemotherapy plus endostar with sequential stereotactic radiotherapy as salvage treatment for recurrent esophageal cancer with severe dyspnea: A case report and review of the literature. Oncol Lett 8: 291-294, 2014.
APA
Xu, M., Huang, H., Xiong, Y., Peng, B., Zhou, Z., Wang, D., & Yang, X. (2014). Combined chemotherapy plus endostar with sequential stereotactic radiotherapy as salvage treatment for recurrent esophageal cancer with severe dyspnea: A case report and review of the literature. Oncology Letters, 8, 291-294. https://doi.org/10.3892/ol.2014.2087
MLA
Xu, M., Huang, H., Xiong, Y., Peng, B., Zhou, Z., Wang, D., Yang, X."Combined chemotherapy plus endostar with sequential stereotactic radiotherapy as salvage treatment for recurrent esophageal cancer with severe dyspnea: A case report and review of the literature". Oncology Letters 8.1 (2014): 291-294.
Chicago
Xu, M., Huang, H., Xiong, Y., Peng, B., Zhou, Z., Wang, D., Yang, X."Combined chemotherapy plus endostar with sequential stereotactic radiotherapy as salvage treatment for recurrent esophageal cancer with severe dyspnea: A case report and review of the literature". Oncology Letters 8, no. 1 (2014): 291-294. https://doi.org/10.3892/ol.2014.2087
Copy and paste a formatted citation
x
Spandidos Publications style
Xu M, Huang H, Xiong Y, Peng B, Zhou Z, Wang D and Yang X: Combined chemotherapy plus endostar with sequential stereotactic radiotherapy as salvage treatment for recurrent esophageal cancer with severe dyspnea: A case report and review of the literature. Oncol Lett 8: 291-294, 2014.
APA
Xu, M., Huang, H., Xiong, Y., Peng, B., Zhou, Z., Wang, D., & Yang, X. (2014). Combined chemotherapy plus endostar with sequential stereotactic radiotherapy as salvage treatment for recurrent esophageal cancer with severe dyspnea: A case report and review of the literature. Oncology Letters, 8, 291-294. https://doi.org/10.3892/ol.2014.2087
MLA
Xu, M., Huang, H., Xiong, Y., Peng, B., Zhou, Z., Wang, D., Yang, X."Combined chemotherapy plus endostar with sequential stereotactic radiotherapy as salvage treatment for recurrent esophageal cancer with severe dyspnea: A case report and review of the literature". Oncology Letters 8.1 (2014): 291-294.
Chicago
Xu, M., Huang, H., Xiong, Y., Peng, B., Zhou, Z., Wang, D., Yang, X."Combined chemotherapy plus endostar with sequential stereotactic radiotherapy as salvage treatment for recurrent esophageal cancer with severe dyspnea: A case report and review of the literature". Oncology Letters 8, no. 1 (2014): 291-294. https://doi.org/10.3892/ol.2014.2087
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