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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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July-2014 Volume 8 Issue 1

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International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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Case Report

Obstructive jaundice due to von Hippel‑Lindau disease‑associated pancreatic lesions: A case report

  • Authors:
    • Xiaoyu Liang
    • Fanguo Hu
    • Zhicheng Ma
    • Nan Li
    • Yan Chen
    • Jie Zhang
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, General Hospital of Tianjin Medical University, Tianjin 300052, P.R. China, Department of General Surgery, Tianjin First Center Hospital, Tianjin 300192, P.R. China
  • Pages: 446-448
    |
    Published online on: April 28, 2014
       https://doi.org/10.3892/ol.2014.2098
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Abstract

von Hippel‑Lindau (VHL) disease is an autosomal dominantly inherited neoplastic syndrome that may lead to pancreatic masses and obstructive jaundice. The present study describes the case of a 20‑year‑old male who suffered from obstructive jaundice due to VHL disease‑associated pancreatic lesions whose primary symptom was dizziness, followed by the appearance of jaundice. Since the excision of the renal cell carcinomas was not possible, the patient also refused surgery to resect the pancreatic head mass. A metallic stent was placed at the stenosis site of the common bile duct. Percutaneous transhepatic cholangiography (PTCD) surgery was later performed following complete blockage of the stent, however, to date, the patient continues to rely on PTCD. VHL disease‑associated pancreatic lesions are rarely the direct cause of mortality, however, obstructive jaundice due to these lesions may be lethal. Therefore, the treatment of patients with incurable renal or central nervous system tumors and obstructive jaundice presents a problem.
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1 

Richard S, Graff J, Lindau J and Resche F: Von Hippel-Lindau disease. Lancet. 363:1231–1234. 2004.

2 

Molino D, Sepe J, Anastasio P and De Santo NG: The history of von Hippel-Lindau disease. J Nephrol. 19(Suppl 10): S119–S123. 2006.

3 

Kim JJ, Rini BI and Hansel DE: Von Hippel Lindau syndrome. Adv Exp Med Biol. 685:228–249. 2010.

4 

Lonser RR, Glenn GM, Walther M, et al: von Hippel-Lindau disease. Lancet. 361:2059–2067. 2003.

5 

Tootee A and Hasani-Ranjbar S: Von hippel-lindau disease: a new approach to an old problem. Int J Endocrinol Metab. 10:619–624. 2012.

6 

Maher ER, Neumann HP and Richard S: Von Hippel-Lindau disease: a clinical and scientific review. Eur J Hum Genet. 19:617–623. 2011.

7 

Zbar B, Kishida T, Chen F, et al: Germline mutations in the Von Hippel-Lindau disease (VHL) gene in families from North America, Europe, and Japan. Hum Mutat. 8:348–357. 1996.

8 

Clark PE and Cookson MS: The von Hippel-Lindau gene: turning discovery into therapy. Cancer. 113(Suppl 7): S1768–S1778. 2008.

9 

Baldewijns MM, van Vlodrop IJ, Vermeulen PB, et al: VHL and HIF signalling in renal cell carcinogenesis. J Pathol. 221:125–138. 2010.

10 

Tamura K, Nishimori I, Ito T, Yamasaki I, Igarashi H and Shuin T: Diagnosis and management of pancreatic neuroendocrine tumor in von Hippel-Lindau disease. World J Gastroenterol. 16:4515–4518. 2010.

11 

Charlesworth M, Verbeke CS, Falk GA, et al: Pancreatic lesions in von Hippel-Lindau disease? A systemic review and meta-synthesis of the literature. J Gastrointest Surg. 16:1422–1428. 2012.

12 

Libutti SK, Choyke PL, Alexander HR, et al: Clinical and genetic analysis of patients with pancreatic neuroendocrine tumors associated with von Hippel-Lindau disease. Surgery. 128:1022–1028. 2000.

13 

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines™). Neuroendocrine tumors. Version 1. National Comphrensive Cancer Network; Fort Washington, PA: pp. 122011

14 

Blansfield JA, Choyke L, Morita SY, Choyke PL, Pingpank JF, Alexander HR, et al: Clinical, genetic and radiographic analysis of 108 patients with von Hippel-Lindau disease (VHL) manifested by pancreatic neuroendocrine neoplasms (PNETs). Surgery. 142:814–818.e2. 2007.

15 

Libutti SK, Choyke PL, Bartlett DL, Vargas H, Walther M, Lubensky I, et al: Pancreatic neuroendocrine tumors associated with von Hippel Lindau disease: diagnostic and management recommendations. Surgery. 124:1153–1159. 1998.

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Copy and paste a formatted citation
Spandidos Publications style
Liang X, Hu F, Ma Z, Li N, Chen Y and Zhang J: Obstructive jaundice due to von Hippel‑Lindau disease‑associated pancreatic lesions: A case report. Oncol Lett 8: 446-448, 2014.
APA
Liang, X., Hu, F., Ma, Z., Li, N., Chen, Y., & Zhang, J. (2014). Obstructive jaundice due to von Hippel‑Lindau disease‑associated pancreatic lesions: A case report. Oncology Letters, 8, 446-448. https://doi.org/10.3892/ol.2014.2098
MLA
Liang, X., Hu, F., Ma, Z., Li, N., Chen, Y., Zhang, J."Obstructive jaundice due to von Hippel‑Lindau disease‑associated pancreatic lesions: A case report". Oncology Letters 8.1 (2014): 446-448.
Chicago
Liang, X., Hu, F., Ma, Z., Li, N., Chen, Y., Zhang, J."Obstructive jaundice due to von Hippel‑Lindau disease‑associated pancreatic lesions: A case report". Oncology Letters 8, no. 1 (2014): 446-448. https://doi.org/10.3892/ol.2014.2098
Copy and paste a formatted citation
x
Spandidos Publications style
Liang X, Hu F, Ma Z, Li N, Chen Y and Zhang J: Obstructive jaundice due to von Hippel‑Lindau disease‑associated pancreatic lesions: A case report. Oncol Lett 8: 446-448, 2014.
APA
Liang, X., Hu, F., Ma, Z., Li, N., Chen, Y., & Zhang, J. (2014). Obstructive jaundice due to von Hippel‑Lindau disease‑associated pancreatic lesions: A case report. Oncology Letters, 8, 446-448. https://doi.org/10.3892/ol.2014.2098
MLA
Liang, X., Hu, F., Ma, Z., Li, N., Chen, Y., Zhang, J."Obstructive jaundice due to von Hippel‑Lindau disease‑associated pancreatic lesions: A case report". Oncology Letters 8.1 (2014): 446-448.
Chicago
Liang, X., Hu, F., Ma, Z., Li, N., Chen, Y., Zhang, J."Obstructive jaundice due to von Hippel‑Lindau disease‑associated pancreatic lesions: A case report". Oncology Letters 8, no. 1 (2014): 446-448. https://doi.org/10.3892/ol.2014.2098
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