Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
July-2014 Volume 8 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2014 Volume 8 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report

Primary extramedullary spinal melanoma mimicking spinal meningioma: A case report and literature review

  • Authors:
    • Yu‑Ping Li
    • Heng‑Zhu Zhang
    • Lei She
    • Xiao‑Dong Wang
    • Lun Dong
    • Enxi Xu
    • Xing‑Dong Wang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Clinical Medical College of Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China, Department of Neurosurgery, Zhenjiang First People's Hospital, Zhenjiang, Jiangsu 212002, P.R. China
  • Pages: 339-344
    |
    Published online on: April 28, 2014
       https://doi.org/10.3892/ol.2014.2099
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Primary spinal melanoma is a rare lesion, which occurs throughout the cranial and spinal regions, however, is primarily observed in the middle or lower thoracic spine. The clinical features of primary spinal melanoma are complex and unspecific, resulting in a high misdiagnosis rate. In the present case report, a rare case of spinal melanoma exhibiting the dural tail sign and mimicking spinal meningioma is reported. The initial diagnosis, using magnetic resonance imaging (MRI), was unclear. Thus, melanin‑containing tumors and spinal meningioma should have been considered in the differential diagnosis. The tumor was completely resected using a standard posterior midline approach, which was followed by chemotherapy. Subsequent to the surgery, the patient was discharged with improved motor capacity and a follow‑up MRI scan showed no recurrence after six months. The present study demonstrates that it is critical for neurosurgeons to focus on increasing the accuracy of initial diagnoses in order to make informed decisions regarding the requirement for surgical resection. The present case report presents the clinical, radiological and pathological features of primary extramedullary spinal melanoma mimicking spinal meningioma to emphasize the importance of early identification and diagnosis.
View Figures

Figure 1

Figure 2

View References

1 

Balch CM, Buzaid AC, Soong SJ, et al: Final version of the American Joint Committee on cancer staging system for cutaneous melanoma. J Clin Oncol. 19:3635–3648. 2001.

2 

Ganiüsmen O, Özer FD, Mete M, Özdemir N and Bayol Ü: Slow progression and benign course of a primary malign melanoma of a lumbar nerve root. Clin Neurol Neurosurg. 114:166–168. 2012.

3 

Fuld AD, Speck ME, Harris BT, et al: Primary melanoma of the spinal cord: a case report, molecular footprint, and review of the literature. J Clin Oncol. 29:e499–e502. 2011.

4 

Lee CH, Moon KY, Chung CK, et al: Primary intradural extramedullary melanoma of the cervical spinal cord: case report. Spine (Phila Pa 1976). 35:E303–E307. 2010.

5 

Hayward RD: Malignant melanoma and the central nervous system. A guide for classification based on the clinical findings. J Neurol Neurosurg Psychiatry. 39:526–530. 1976.

6 

Bhatia S, Tykodi SS and Thompson JA: Treatment of metastatic melanoma: an overview. Oncology (Williston Park). 23:488–496. 2009.

7 

Yu J, Zhao DD, Chen S, Zhang JM and Xu J: Primary melanoma of the cervical spine with cerebral metastases: case report and review of the literature. J Int Med Res. 40:1207–1215. 2012.

8 

Yu J, Zhao DD, Chen S, et al: Primary melanoma of the cervical spine with cerebral metastases: case report and review of the literature. J Int Med Res. 40:1207–1215. 2012.

9 

Yan L, Chang Z, Liu Y, et al: Primary spinal melanoma: a case report and literature review. Chin Med J (Engl). 125:4138–4141. 2012.

10 

Fuld AD, Speck ME, Harris BJ, et al: Primary melanoma of the spinal cord: a case report, molecular footprint, and review of the literature. J Clin Oncol. 29:e499–e502. 2011.

11 

Vij M, Jaiswal S, Jaiswal AK and Behari S: Primary spinal melanoma of the cervical leptomeninges: report of a case with brief review of literature. Neurol India. 58:781–783. 2010.

12 

Lee CH, Moon KY, Chung CK, et al: Primary intradural extramedullary melanoma of the cervical spinal cord: case report. Spine (Phila Pa 1976). 35:E303–E307. 2010.

13 

Kolasa M, Jesionek-Kupnicka D, Kordek R and Kolasa P: Primary spinal cord melanoma - a case report. Folia Neuropathol. 48:212–216. 2010.

14 

Kim MS, Yoon DH and Shin DA: Primary spinal cord melanoma. J Korean Neurosurg Soc. 48:157–161. 2010.

15 

Jo KW, Kim SR, Kim SD and Park IS: Primary thoracic epidural melanoma: a case report. Asian Spine J. 4:48–51. 2010.

16 

Kounin GK, Romansky KV, Traykov LD, et al: Primary spinal melanoma with bilateral papilledema. Clin Neurol Neurosurg. 107:525–527. 2005.

17 

Kwon SC, Rhim SC, Lee DH, et al: Primary malignant melanoma of the cervical spinal nerve root. Yonsei Med J. 45:345–348. 2004.

18 

Tosaka M, Tamura M, Oriuchi N, et al: Cerebrospinal fluid immunocytochemical analysis and neuroimaging in the diagnosis of primary leptomeningeal melanoma. Case report. J Neurosurg. 94:528–532. 2001.

19 

Farrokh D, Fransen P and Faverly D: MR findings of a primary intramedullary malignant melanoma: case report and literature review. AJNR Am J Neuroradiol. 22:1864–1866. 2001.

20 

Bidziński J, Kroh H, Leszczyk C and Bojarski P: Primary intraspinal cervical melanoma. Acta Neurochir (Wien). 142:1069–1070. 2000.

21 

Brat DJ, Giannini C, Scheithauer BW and Burger PC: Primary melanocytic neoplasms of the central nervous systems. Am J Surg Pathol. 23:745–754. 1999.

22 

Salame K, Merimsky O, Yosipov J, et al: Primary intramedullary spinal melanoma: diagnostic and treatment problems. J Neurooncol. 36:79–83. 1998.

23 

François P, Lioret E and Jan M: Primary spinal melanoma: case report. Br J Neurosurg. 12:179–182. 1998.

24 

Salpietro FM, Alafaci C, Gervasio O, et al: Primary cervical melanoma with brain metastases. Case report and review of the literature. J Neurosurg. 89:659–666. 1998.

25 

Magni C, Yapo P, Mocaer J, et al: Primary intramedullary melanoma. Apropos of a case. J Neuroradiol. 23:41–45. 1996.(In French).

26 

Yamasaki T, Kikuchi H, Yamashita J, et al: Primary spinal intramedullary malignant melanoma: case report. Neurosurgery. 25:117–121. 1989.

27 

Schmidt P, Neuen JE, Blanke M, et al: Primary malignant melanoblastosis of the meninges. Clinical, cytologic and neuropathologic findings in a case. Acta Cytol. 32:713–718. 1988.

28 

Larson TC, Houser OW, Onofrio BM, et al: Primary spinal melanoma. J Neurosurg. 66:47–49. 1987.

29 

Ozden B, Barlas O and Hacihanefioğlu U: Primary dural melanomas: report of two cases and review of the literature. Neurosurgery. 15:104–107. 1984.

30 

Holaday WJ and Evans EB: Spinal (meningeal) melanoma. A case report. J Bone Joint Surg Am. 50:738–742. 1968.

31 

Clifford JH, McClintock HG and Lubchenco AE: Primary spinal cord malignant melanoma: case report. J Neurosurg. 29:410–413. 1968.

32 

Kiel FW, Starr LB and Hansen JL: Primary melanoma of the spinal cord. J Neurosurg. 18:616–629. 1961.

33 

Hirano A and Carton CA: Primary malignant melanoma of the spinal cord. J Neurosurg. 17:935–944. 1960.

34 

Zimmerman HM and Adams RD: Seminar on diseases of nervous tissue and muscle. In: Presented at 24th seminar of American Society of Clinical Pathologists; Chicago. 1958

35 

Gibson JB, Burrows D and Weir WP: Primary melanoma of the meninges. J Pathol Bacteriol. 74:419–438. 1957.

36 

Roca de VR, Elizalde AC and Coma FA: A CNS melanoma: the practice of three clinical cases. Med Clín. 22:304–311. 1954.

37 

Ruben PF: Spinal melanoma. Neurocirugia. 9:81953.(In Undetermined Language).

38 

King AB, Chambers JW and Garey J: Primary malignant melanoma of the spinal cord. AMA Arch Neurol Psychiatry. 68:266–275. 1952.

39 

De Assis and De Luccia: Primary melanoma due to cauda equina. Rev Paul Med. 39:388–389. 1951.(In Undertermined Language).

40 

King AB and Propst HD: Melanomas of the central nervous system: description of a primary spinal cord melanoma. Guthrie Clin Bull. 21:19–29. 1951.

41 

Forbes W and Maloney AF: Primary melanomatosis of the leptomeninx. J Pathol Bacteriol. 62:403–409. 1950.

42 

Kissel P, Rousseaux R, Beau A, et al: Primary meningeal melanoma with bulbo-cervical localization. Rev Neurol (Paris). 82:385–389. 1950.(In Undetermined Language).

43 

Castaner AE, Oliveras de la Riva C and Barraquer-Bordas L: Primitive melanoma of the cauda equina. Monatsschr Psychiatr Neurol. 120:227–236. 1950.

44 

Mackay FH and Hurteau EF: Primary melanoma of the central nervous system. J Nerv Ment Dis. 96:369–377. 1942.

45 

Garcin R, Petit DD and Bertrand I: Mélanoblastome primitif de la queue de cheval. Rev neurol. 73:255–257. 1941.

46 

Da Costa DG and Love JG: Primary melano-epithelioma of the spinal cord. Proc Staff Meet Mayo Clin. 14:628–631. 1939.

47 

Schnitker MT and Ayer D: The primary melanomas of the leptomeninges. A clinico-pathologic study with a review of the literature and the report of an additional case. J Nerv Ment Dis. 87:45–73. 1938.

48 

Van Bogaert and Verbrugge J: A meningoblastoma inclusions in spinal melanoma. J Beige Neurol Psychiat. 33:813–817. 1933.

49 

De Blasi: A primitive melanoma of spinal cord. Pathologica. 22:606–613. 1930.

50 

Bell FG: Primary melano-sarcoma of the spinal arachnoid. J Coll Surg Australasia. 3:2791930.

51 

Prussak B and Mackiewicz J: A case of spinal cord chromatophoroma. Rev Neurol. 2:2321929.

52 

Ringertz N: Two cases of pigmented tumor of the spinal cord. Rev Neurol. 1:451–461. 1926.

53 

Schmid HJ: A case of primary melanoma of the spinal cord. Frankfurt Z Path. 33:372–379. 1926.

54 

Koelichen J: Spinal cord chromatophoroma. Ztschr Fd Ges Neurol Psychiat. 31:174–183. 1916.

55 

Lindbom O: A case of chromatophoroma originate from spinal dural. Hygiea. 74:198–218. 1912.

56 

Kawashima K: About a sarcoma of the dura mater and its dissemination in the meningeal space with diffuse pigmentation of the leptomeninges. Virchows Arch. 201:297–311. 1910.

57 

Esser: About a rare spinal cord of chromatophorom (Chromatophorom). Dtsch Z Nervenheilk. 32:118–123. 1907.

58 

Boit H: A case of chromatophoroma originate from spinal dural. Contribution to the knowledge of the pial chromatophoroma. Frank Z Pathol. 1:248–266. 1907.

59 

Hirschberg A: Spinal cord of chromatophoroma. A contribution to the knowledge of the primary chromatophorome the central nervous system. Virchows Arch. 186:229–240. 1906.

60 

Katalinic D, Anic B, Stern-Padovan R, et al: Low back pain as the presenting sign in a patient with primary extradural melanoma of the thoracic spine - a metastatic disease 17 years after complete surgical resection. World J Surg Oncol. 17:1502011.

61 

Hamilton AJ, Lulu BA, Fosmire H, Stea B and Cassady JR: Preliminary clinical experience with linear accelerator-based spinal stereotactic radiosurgery. Neurosurgery. 36:311–319. 1995.

62 

O’Day SJ, Atkins MB, Boasberg P, et al: Phase II multicenter trial of maintenance biotherapy after induction concurrent Biochemotherapy for patients with metastatic melanoma. J Clin Oncol. 27:6207–6212. 2009.

63 

Wheatley K, Ives N, Eggermont A, et al: Interferon-α as adjuvant therapy for melanoma: an individual patient data meta-analysis of randomised trials. J Clin Oncol. 25:85262007.

64 

Hodi FS, O’Day SJ, McDermott DF, et al: Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med. 363:711–723. 2010.

65 

Robert C, Thomas L, Bondarenko I, et al: Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med. 364:2517–2526. 2011.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li YP, Zhang HZ, She L, Wang XD, Dong L, Xu E and Wang XD: Primary extramedullary spinal melanoma mimicking spinal meningioma: A case report and literature review. Oncol Lett 8: 339-344, 2014.
APA
Li, Y., Zhang, H., She, L., Wang, X., Dong, L., Xu, E., & Wang, X. (2014). Primary extramedullary spinal melanoma mimicking spinal meningioma: A case report and literature review. Oncology Letters, 8, 339-344. https://doi.org/10.3892/ol.2014.2099
MLA
Li, Y., Zhang, H., She, L., Wang, X., Dong, L., Xu, E., Wang, X."Primary extramedullary spinal melanoma mimicking spinal meningioma: A case report and literature review". Oncology Letters 8.1 (2014): 339-344.
Chicago
Li, Y., Zhang, H., She, L., Wang, X., Dong, L., Xu, E., Wang, X."Primary extramedullary spinal melanoma mimicking spinal meningioma: A case report and literature review". Oncology Letters 8, no. 1 (2014): 339-344. https://doi.org/10.3892/ol.2014.2099
Copy and paste a formatted citation
x
Spandidos Publications style
Li YP, Zhang HZ, She L, Wang XD, Dong L, Xu E and Wang XD: Primary extramedullary spinal melanoma mimicking spinal meningioma: A case report and literature review. Oncol Lett 8: 339-344, 2014.
APA
Li, Y., Zhang, H., She, L., Wang, X., Dong, L., Xu, E., & Wang, X. (2014). Primary extramedullary spinal melanoma mimicking spinal meningioma: A case report and literature review. Oncology Letters, 8, 339-344. https://doi.org/10.3892/ol.2014.2099
MLA
Li, Y., Zhang, H., She, L., Wang, X., Dong, L., Xu, E., Wang, X."Primary extramedullary spinal melanoma mimicking spinal meningioma: A case report and literature review". Oncology Letters 8.1 (2014): 339-344.
Chicago
Li, Y., Zhang, H., She, L., Wang, X., Dong, L., Xu, E., Wang, X."Primary extramedullary spinal melanoma mimicking spinal meningioma: A case report and literature review". Oncology Letters 8, no. 1 (2014): 339-344. https://doi.org/10.3892/ol.2014.2099
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team