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Article

The role of mast cell tryptases in cardiac myxoma: Histogenesis and development of a challenging tumor

  • Authors:
    • Giuseppe Donato
    • Francesco Conforti
    • Caterina Camastra
    • Michele Ammendola
    • Annalidia Donato
    • Attilio Renzulli
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, School of Medicine, University Magna Graecia, Catanzaro I‑88100, Italy, Department of Pharmacology and 3Cardiac Surgery, School of Medicine, University Magna Graecia, Catanzaro I‑88100, Italy, Department of Cardiac Surgery, School of Medicine, University Magna Graecia, Catanzaro I‑88100, Italy
  • Pages: 379-383
    |
    Published online on: April 29, 2014
       https://doi.org/10.3892/ol.2014.2104
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Abstract

A number of available studies have focused on the role of mastocytes and their angiogenic factors, such as tryptase expression, in cancer growth as a major research objective. Cardiac myxoma is a rare neoplasia and is the most common primary tumor of the heart. The cellular elements of cardiac myxoma have an endothelial phenotype; however, its histogenesis remains unclear. Currently, no available studies have correlated the pathological characteristics of cardiac myxomas, such as cell differentiation and vascularization, with the angiogenic factors of mast cells. The aim of the present study was to investigate the role of mast cell tryptases on the development of cardiac myxomas and examine the histogenesis of tumoral cells. A series of 10 cardiac myxomas were examined by immunohistochemical analysis for the presence of tryptase‑positive mast cells. Statistical analysis of our data demonstrated that angiogenesis and the development of pseudovascular structures were correlated with the number of tryptase‑positive mast cells. Therefore, we hypothesize that cardiac myxoma cells are endothelial precursors which are able to generate mature vascular structures. Further morphological and immunophenotypic analyses of tumoral cells may corroborate such a hypothesis.
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Copy and paste a formatted citation
Spandidos Publications style
Donato G, Conforti F, Camastra C, Ammendola M, Donato A and Renzulli A: The role of mast cell tryptases in cardiac myxoma: Histogenesis and development of a challenging tumor. Oncol Lett 8: 379-383, 2014.
APA
Donato, G., Conforti, F., Camastra, C., Ammendola, M., Donato, A., & Renzulli, A. (2014). The role of mast cell tryptases in cardiac myxoma: Histogenesis and development of a challenging tumor. Oncology Letters, 8, 379-383. https://doi.org/10.3892/ol.2014.2104
MLA
Donato, G., Conforti, F., Camastra, C., Ammendola, M., Donato, A., Renzulli, A."The role of mast cell tryptases in cardiac myxoma: Histogenesis and development of a challenging tumor". Oncology Letters 8.1 (2014): 379-383.
Chicago
Donato, G., Conforti, F., Camastra, C., Ammendola, M., Donato, A., Renzulli, A."The role of mast cell tryptases in cardiac myxoma: Histogenesis and development of a challenging tumor". Oncology Letters 8, no. 1 (2014): 379-383. https://doi.org/10.3892/ol.2014.2104
Copy and paste a formatted citation
x
Spandidos Publications style
Donato G, Conforti F, Camastra C, Ammendola M, Donato A and Renzulli A: The role of mast cell tryptases in cardiac myxoma: Histogenesis and development of a challenging tumor. Oncol Lett 8: 379-383, 2014.
APA
Donato, G., Conforti, F., Camastra, C., Ammendola, M., Donato, A., & Renzulli, A. (2014). The role of mast cell tryptases in cardiac myxoma: Histogenesis and development of a challenging tumor. Oncology Letters, 8, 379-383. https://doi.org/10.3892/ol.2014.2104
MLA
Donato, G., Conforti, F., Camastra, C., Ammendola, M., Donato, A., Renzulli, A."The role of mast cell tryptases in cardiac myxoma: Histogenesis and development of a challenging tumor". Oncology Letters 8.1 (2014): 379-383.
Chicago
Donato, G., Conforti, F., Camastra, C., Ammendola, M., Donato, A., Renzulli, A."The role of mast cell tryptases in cardiac myxoma: Histogenesis and development of a challenging tumor". Oncology Letters 8, no. 1 (2014): 379-383. https://doi.org/10.3892/ol.2014.2104
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