Enteropathy‑associated T‑cell lymphoma presenting with gastrointestinal tract symptoms: A report of two cases and review of diagnostic challenges and clinicopathological correlation

Jiao,Guohui; Zheng,Zhongqing; Jiang,Kui; Zhang,Jie; Wang,Bangmao

doi:10.3892/ol.2014.2105

July-2014 Volume 8 Issue 1

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

July-2014 Volume 8 Issue 1

Full Size Image

Article

Enteropathy‑associated T‑cell lymphoma presenting with gastrointestinal tract symptoms: A report of two cases and review of diagnostic challenges and clinicopathological correlation

Authors:
- Guohui Jiao
- Zhongqing Zheng
- Kui Jiang
- Jie Zhang
- Bangmao Wang
View Affiliations / Copyright

Affiliations: Department of Gastroenterology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China
Pages: 91-94
|
Published online on: April 29, 2014

https://doi.org/10.3892/ol.2014.2105
Expand metrics +

Abstract

The gastrointestinal tract is the most common location for primary extranodal non‑Hodgkin lymphoma (NHL) with cases less commonly found in the intestine. The majority of primary intestinal B‑cell lymphomas are exophytic, whereas enteropathy‑associated T‑cell lymphomas present predominantly as thickened plaques, ulcers or strictures. Crohn's disease (CD) is a chronic inflammatory disease of the intestines with fissures and ulcers, which is difficult for clinicians to diagnose based on endoscopic observations alone. Malignant lymphoma must be considered when clinically diagnosed CD is refractory to medication or when its clinical course becomes aggressive. The current study presents a rare case of primary colon T‑cell lymphoma in a 16‑year‑old male with poor prognosis, as well as a case of gastrointestinal lymphoma occurring in the duodenum and colon in a 62‑year‑old male with a 10‑year history of NHL. It was difficult to determine the diagnosis by a single endoscopic biopsy as the majority of biopsy specimens revealed mixed inflammation within which the lymphoma cells were difficult to identify. The present study indicated that it is important to recognize ulcerative or stenotic lymphoma and to differentiate it from CD as it exhibits a much more aggressive clinical behavior. The correct diagnosis may be confirmed by careful histopathological study and ancillary examination.

View Figures

View References

1	Ibrahim EM, Ezzat AA, El-Weshi AN, et al: Primary intestinal diffuse large B-cell non-Hodgkin’s lymphoma: clinical features, management, and prognosis of 66 patients. Ann Oncol. 12:53–58. 2001.
2	Chandesris MO, Malamut G, et al: Enteropathy-associated T-cell lymphoma: a review on clinical presentation, diagnosis, therapeutic strategies and perspectives. Gastroenterol Clin Biol. 34:590–605. 2010.
3	Zheng S, Xu H, Ouyang Q, et al: A case of rapid growing colonic NK/T cell lymphoma complicated by Crohn’s disease. Chin J Cancer Res. 25:119–123. 2013.
4	van de Water JM, Cillessen SA, Visser OJ, Verbeek WH, Meijer CJ and Mulder CJ: Enteropathy associated T-cell lymphoma and its precursor lesions. Best Pract Res Clin Gastroenterol. 24:43–56. 2010.
5	Ko YH, Cho EY, Kim JE, et al: NK and NK-like T-cell lymphoma in extranasal sites: a comparative clinicopathological study according to site and EBV status. Histopathology. 44:480–489. 2004.
6	Busto Bea V, Crespo Pérez L, Rodríguez-Gandía MÁ, et al: Enteropathy-associated T-cell lymphoma: a diagnostic challenge. Gastroenterol Hepatol. 34:686–689. 2011.(In Spanish).
7	Ng SB, Lai KW, Murugaya S, et al: Nasal-type extranodal natural killer/T-cell lymphomas: a clinicopathologic and genotypic study of 42 cases in Singapore. Mod Pathol. 17:1097–1107. 2004.
8	Bautista-Quach MA, Ake CD, Chen M and Wang J: Gastrointestinal lymphomas: Morphology, immunophenotype and molecular features. J Gastrointest Oncol. 3:209–225. 2012.
9	Dayharsh GA, Loftus EV Jr, Sandborn WJ, Tremaine WJ, Zinsmeister AR, Witzig TE, Macon WR and Burgart LJ: Epstein-Barr virus-positive lymphoma in patients with infammatory bowel disease treated with azathioprine or 6-mercaptopurine. Gastroenterology. 122:72–77. 2002.
10	Askling J, Brandt L, Lapidus A, et al: Risk of haematopoietic cancer in patients with infammatory bowel disease. Gut. 54:617–622. 2005.
11	Kang HY, Hwang JH, Park YS, et al: Angioimmunoblastic T-cell lymphoma mimicking Crohn’s disease. Dig Dis Sci. 52:2743–2747. 2007.
12	Radić-Kristo D, Planinc-Peraica A, Ostojić S, et al: Primary gastrointestinal non-Hodgkin lymphoma in adults: clinicopathologic and survival characteristics. Coll Antropol. 34:413–417. 2010.
13	Chera R, Gupta AA, Bailey D, et al: Small intestinal B-cell lymphoma in a patient with lymphangiectasia secondary to abdominal lymphangioma. J Clin Oncol. 26:675–678. 2008.
14	Nishimura M and Tomo K: A case of enteropathy-associated T-cell lymphoma: diagnosis by flow cytometric immunophenotyping and genome analysis using ascitic fluid. Int J Clin Oncol. 16:778–782. 2011.
15	Malamut G, Verkarre V, Callens C, et al: Enteropathy-associated T-cell lymphoma complicating an autoimmune enteropathy. Gastroenterology. 142:726–729. 2012.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Enteropathy‑associated T‑cell lymphoma presenting with gastrointestinal tract symptoms: A report of two cases and review of diagnostic challenges and clinicopathological correlation

This article is mentioned in:

Abstract

Figure 1

Related Articles