Effect of clinical symptoms on the indication for selective neck dissection for N0 carcinomas of the parotid gland

Maruo,Takashi; Fujimoto,Yasushi; Yoshida,Kenji; Hiramatsu,Mariko; Suzuki,Atsushi; Nishio,Naoki; Shimono,Mariko; Nakashima,Tsutomu

doi:10.3892/ol.2014.2137

July-2014 Volume 8 Issue 1

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July-2014 Volume 8 Issue 1

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Article

Effect of clinical symptoms on the indication for selective neck dissection for N0 carcinomas of the parotid gland

Authors:
- Takashi Maruo
- Yasushi Fujimoto
- Kenji Yoshida
- Mariko Hiramatsu
- Atsushi Suzuki
- Naoki Nishio
- Mariko Shimono
- Tsutomu Nakashima
View Affiliations / Copyright

Affiliations: Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466‑8550, Japan
Pages: 335-338
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Published online on: May 12, 2014

https://doi.org/10.3892/ol.2014.2137
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Abstract

Lymph node metastasis is a major prognostic factor in parotid carcinoma, however, the pre‑operative diagnosis of occult nodal metastasis is difficult in clinical N0 (cN0) parotid cancer patients. In addition, the indication of neck dissection in T1‑3 cN0 patients is controversial. The current study investigated 17 patients with clinical T1‑3 cN0 parotid cancer, and analyzed the correlation between patient symptoms/findings and pathological N status/tumor histological grade. In the statistical analysis, pain was found to significantly correlate with neck metastasis. Furthermore, cN0‑staged patients without pain exhibited no neck metastasis. However, no significant correlation was identified between patient symptoms or findings and histological grade. These results indicate the possibility that selective neck dissection can be omitted for T1‑3 cN0‑staged patients without pain.

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1	Spiro RH: Salivary neoplasms: overview of a 35-year experience with 2,807 patients. Head Neck Surg. 8:177–184. 1986.
2	Carrillo JF, Vázquez R, Ramírez-Ortega MC, et al: Multivariate prediction of the probability of recurrence in patients with carcinoma of the parotid gland. Cancer. 109:2043–2051. 2007.
3	Bhattacharyya N and Fried MP: Nodal metastasis in major salivary gland cancer: predictive factors and effects on survival. Arch Otolaryngol Head Neck Surg. 128:904–908. 2002.
4	Régis De Brito Santos I, Kowalski LP, Cavalcante De Araujo V, Flávia Logullo A and Magrin J: Multivariate analysis of risk factors for neck metastases in surgically treated parotid carcinomas. Arch Otolaryngol Head Neck Surg. 127:56–60. 2001.
5	Medina JE: Neck dissection in the treatment of cancer of major salivary glands. Otolaryngol Clin North Am. 31:815–822. 1998.
6	Kawata R, Koutetsu L, Yoshimura K, Nishikawa S and Takenaka H: Indication for elective neck dissection for N0 carcinoma of the parotid gland: a single institution’s 20-year experience. Acta Otolaryngol. 130:286–292. 2010.
7	National Comprehensive Cancer Network. Clinical Practice Guidelines in Oncology™ Head and Neck Cancer Version 1.2012. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp. Accessed April 26, 2012
8	Hocwald E, Korkmaz H, Yoo GH, et al: Prognostic factors in major salivary gland cancer. Laryngoscope. 111:1434–1439. 2001.
9	Lima RA, Tavares MR, Dias FL, et al: Clinical prognostic factors in malignant parotid gland tumors. Otolaryngol Head Neck Surg. 133:702–708. 2005.
10	Spiro RH, Huvos AG, Berk R and Strong EW: Mucoepidermoid carcinoma of salivary gland origin. A clinicopathologic study of 367 cases. Am J Surg. 136:461–468. 1978.
11	Hicks MJ, el-Naggar AK, Flaitz CM, Luna MA and Batsakis JG: Histocytologic grading of mucoepidermoid carcinoma of major salivary glands in prognosis and survival: a clinicopathologic and flow cytometric investigation. Head Neck. 17:89–95. 1995.
12	Frankenthaler RA, Luna MA, Lee SS, et al: Prognostic variables in parotid gland cancer. Arch Otolaryngol Head Neck Surg. 117:1251–1256. 1991.
13	Armstrong JG, Harrison LB, Thaler HT, et al: The indications for elective treatment of the neck in cancer of the major salivary glands. Cancer. 69:615–619. 1992.
14	Kelley DJ and Spiro RH: Management of the neck in parotid carcinoma. Am J Surg. 172:695–697. 1996.
15	Stodulski D, Mikaszewski B and Stankiewicz C: Signs and symptoms of parotid gland carcinoma and their prognostic value. Int J Oral Maxillofac Surg. 41:801–806. 2012.
16	Pohar S, Gay H, Rosenbaum P, et al: Malignant parotid tumors: presentation, clinical/pathologic prognostic factors, and treatment outcomes. Int J Radiat Oncol Biol Phys. 61:112–118. 2005.
17	Rafla S: Malignant parotid tumors: natural history and treatment. Cancer. 40:136–144. 1977.
18	Fordice J, Kershaw C, El-Naggar A and Goepfert H: Adenoid cystic carcinoma of the head and neck: predictors of morbidity and mortality. Arch Otolaryngol Head Neck Surg. 125:149–152. 1999.
19	Pedersen D, Overgaard J, Søgaard H, Elbrønd O and Overgaard M: Malignant parotid tumors in 110 consecutive patients: treatment results and prognosis. Laryngoscope. 102:1064–1069. 1992.
20	Therkildsen MH, Christensen M, Andersen LJ, Schiødt T and Hansen HS: Salivary gland carcinomas - prognostic factors. Acta Oncol. 37:701–713. 1998.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Effect of clinical symptoms on the indication for selective neck dissection for N0 carcinomas of the parotid gland

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