Diagnosis and treatment of carcinosarcoma of the renal pelvis: A case report

Dong,Biao; Zhang,Jian‑Jian; Chen,Chao; Wang,Yuan‑Tao; Zhai,Xiu‑Yu; Fu,Yao‑Wen; Zhou,Hong‑Lan

doi:10.3892/ol.2014.2145

Diagnosis and treatment of carcinosarcoma of the renal pelvis: A case report

Authors:
- Biao Dong
- Jian‑Jian Zhang
- Chao Chen
- Yuan‑Tao Wang
- Xiu‑Yu Zhai
- Yao‑Wen Fu
- Hong‑Lan Zhou
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Affiliations: Department of Urology, First Hospital of Jilin University, Jilin, Changchun 130021, P.R. China, Department of Hepatic Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, P.R. China, Department of Critical Care Medicine, Henan Province People's Hospital, Zhengzhou, Henan 450003, P.R. China
Published online on: May 13, 2014 https://doi.org/10.3892/ol.2014.2145
Pages: 467-469

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Abstract

Carcinosarcoma is a rare type of renal pelvis malignancy, the diagnosis of which requires the presence of malignant epithelial and mesenchymal components. The prognosis of this disease is extremely poor due to its rapid progression and widespread metastases. The present study describes a case of carcinosarcoma involving the right renal pelvis in a 73‑year‑old female who presented with intermittent hematuria and right‑flank pain that had persisted for one month. Computed tomography revealed a 2.4x2.5 cm mass in the right renal pelvis, which was diagnosed as a right renal pelvic tumor. Laparoscopic radical resection of the right kidney and ureter was performed. Following surgery, immunohistochemical analysis showed positive reactions for epithelial and mesenchymal markers. Based on these findings, the patient was diagnosed with carcinosarcoma. Thus, immunohistochemical analysis is a critical method for the accurate diagnosis of carcinosarcoma.

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1	Chiu KC, Lin MC, Liang YC and Chen CY: Renal carcinosarcoma: case report and review of literature. Ren Fail. 30:1034–1039. 2008.
2	Fauci PA Jr, Therhag HG and Davis JE: Carcinosarcoma of the renal pelvis. J Urol. 85:897–902. 1961.
3	Dimitriou RJ, Gattuso P and Coogan CL: Carcinosarcoma of the renal pelvis. Urology. 56:5082000.
4	Yilmaz E, Birlik B, Arican Z, et al: Carcinosarcoma of the renal pelvis and urinary bladder: a case report. Korean J Radiol. 4:255–259. 2003.
5	Lema Grille J, Blanco Parra M, Suárez Peñaranda JM and Durana Tonder C: Carcinosarcoma of the renal pelvis: report of a case and review of the literature. Actas Urol Esp. 26:509–512. 2002.(In Spanish).
6	Vermeulen P, Hoekx L, Colpaert C, et al: Biphasic sarcomatoid carcinoma (carcinosarcoma) of the renal pelvis with heterologous chondrogenic differentiation. Virchows Arch. 437:194–197. 2000.
7	Reuter VE: Sarcomatoid lesions of the urogenital tract. Semin Diagn Pathol. 10:188–201. 1993.
8	Völker HU, Zettl A, Schön G, et al: Molecular genetic findings in two cases of sarcomatoid carcinoma of the ureter: evidence for evolution from a common pluripotent progenitor cell? Virchows Arch. 452:457–463. 2008.
9	Perret L, Chaubert P, Hessler D and Guillou L: Primary heterologous carcinosarcoma (metaplastic carcinoma) of the urinary bladder: a clinicopathologic, immunohistochemical, and ultrastructural analysis of eight cases and a review of the literature. Cancer. 82:1535–1549. 1998.
10	Baschinsky DY, Chen JH, Vadmal MS, et al: Carcinosarcoma of the urinary bladder - an aggressive tumor with diverse histogenesis. A clinicopathologic study of 4 cases and review of the literature. Arch Pathol Lab Med. 124:1172–1178. 2000.
11	Rao MS, Lotuaco LG and McGregor DH: Carcinosarcoma of the adult kidney. Postgrad Med J. 53:408–411. 1977.
12	Chen KT, Workman RD, Flam MS and DeKlotz RJ: Carcinosarcoma of renal pelvis. Urology. 22:429–431. 1983.
13	Ridolfi RL and Eggleston JC: Carcinosarcoma of the renal pelvis. J Urol. 119:569–572. 1978.
14	Pusiol T, Morichetti D, Zorzi MG and Piscioli F: Carcinosarcoma of the renal pelvis: inaccurate documentation of origin and incomplete review of the literature. Ren Fail. 33:844–845. 2011.
15	Wang J, Wang FW and Kessinger A: The natural history and outcomes of the patients with carcinosarcoma involving kidney and renal pelvis. Adv Urol. 2011:6939642011.
16	Tarry WF, Morabito RA and Belis JA: Carcinosarcoma of the renal pelvis with extension into the renal vein and inferior vena cava. J Urol. 128:582–585. 1982.
17	Tajima Y and Aizawa M: Unusual renal pelvic tumor containing transitional cell carcinoma, adenocarcinoma and sarcomatoid elements (so-called sarcomatoid carcinoma of the renal pelvis). A case report and review of the literature. Acta Pathol Jpn. 38:805–814. 1988.
18	Lopez-Beltran A, Escudero AL, Cavazzana AO, et al: Sarcomatoid transitional cell carcinoma of the renal pelvis. A report of five cases with clinical, pathological, immunohistochemical and DNA ploidy analysis. Pathol Res Pract. 192:1218–1224. 1996.
19	Orsatti G, Corgan FJ and Goldberg SA: Carcinosarcoma of urothelial organs: sequential involvement of urinary bladder, ureter, and renal pelvis. Urology. 41:289–291. 1993.
20	Johnin K, Kadowaki T, Kushima M, et al: Primary heterologous carcinosarcoma of the ureter with necrotic malignant polyps. Report of a case and review of the literature. Urol Int. 70:232–235. 2003.