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Article Open Access

Comparison of K-ras mutations in lung, colorectal and gastric cancer

  • Authors:
    • Nanqiu Peng
    • Xintai Zhao
  • View Affiliations / Copyright

    Affiliations: Technical Department, Shanghai Shines Pharmaceuticals Company Limited, Research Base of Molecular Diagnosis Technology for Tumor Personalized Therapy, Development Center for Medical Science and Technology, Ministry of Health, Shanghai 201900, P.R. China
  • Pages: 561-565
    |
    Published online on: May 30, 2014
       https://doi.org/10.3892/ol.2014.2205
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Abstract

K-ras is involved in the EGFR pathway that regulates cell survival, motility and proliferation, as well as angiogenesis and metastasis. It is also essential for carcinogenesis. The K-ras mutation status can be used to predict the therapeutic efficacy of targeted drugs such as cetuximab. The aim of this study was to compare K-ras mutation in different types of cancer. Nested and COLD-PCR were used to detect K-ras mutations. The Chi-squared test was used for statistical analysis. In this study, the total K-ras mutation frequency was found to be 9.09, 18.61 and 6.67% in lung, colorectal and gastric cancer, respectively. Similar K-ras mutation frequencies were detected among sample types and genders for lung and gastric cancer, with the exception of colorectal cancer. However, age had no impact on the K-ras mutation rates.
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Copy and paste a formatted citation
Spandidos Publications style
Peng N and Zhao X: Comparison of K-ras mutations in lung, colorectal and gastric cancer. Oncol Lett 8: 561-565, 2014.
APA
Peng, N., & Zhao, X. (2014). Comparison of K-ras mutations in lung, colorectal and gastric cancer. Oncology Letters, 8, 561-565. https://doi.org/10.3892/ol.2014.2205
MLA
Peng, N., Zhao, X."Comparison of K-ras mutations in lung, colorectal and gastric cancer". Oncology Letters 8.2 (2014): 561-565.
Chicago
Peng, N., Zhao, X."Comparison of K-ras mutations in lung, colorectal and gastric cancer". Oncology Letters 8, no. 2 (2014): 561-565. https://doi.org/10.3892/ol.2014.2205
Copy and paste a formatted citation
x
Spandidos Publications style
Peng N and Zhao X: Comparison of K-ras mutations in lung, colorectal and gastric cancer. Oncol Lett 8: 561-565, 2014.
APA
Peng, N., & Zhao, X. (2014). Comparison of K-ras mutations in lung, colorectal and gastric cancer. Oncology Letters, 8, 561-565. https://doi.org/10.3892/ol.2014.2205
MLA
Peng, N., Zhao, X."Comparison of K-ras mutations in lung, colorectal and gastric cancer". Oncology Letters 8.2 (2014): 561-565.
Chicago
Peng, N., Zhao, X."Comparison of K-ras mutations in lung, colorectal and gastric cancer". Oncology Letters 8, no. 2 (2014): 561-565. https://doi.org/10.3892/ol.2014.2205
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