Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
August-2014 Volume 8 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2014 Volume 8 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

CD1d levels in peripheral blood of patients with acute myeloid leukemia and acute lymphoblastic leukemia

  • Authors:
    • Wenjian Guo
    • Aishu Dong
    • Chao Xing
    • Xiaoji Lin
    • Xiahui Pan
    • Ying Lin
    • Baoling Zhu
    • Muqing He
    • Rong‑Xing Yao
  • View Affiliations / Copyright

    Affiliations: Department of Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 0577, P.R. China
  • Pages: 825-830
    |
    Published online on: June 2, 2014
       https://doi.org/10.3892/ol.2014.2208
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The antitumor effect of natural killer T cells has been reported in several studies analyzing the expression of CD1d on antigen‑presenting cells (APCs). Therefore, the present study questioned whether APCs may be abnormal in the peripheral blood (PB) of acute leukemia (AL) patients, particularly the levels of CD1d. To improve the understanding of the role of CD1d on APCs, the levels of CD1d on monocytes were analyzed in healthy controls, AL patients and AL patients with complete remission (CR). In addition, the correlation between the number of CD3+CD56+ T lymphocytes and levels of CD1d on monocytes was analyzed. Flow cytometry was used to determine the levels of CD1d on monocytes and lymphocytes. A significant decrease was observed in the levels of CD1d on monocytes in the PB of acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) patients compared with the healthy controls. Simultaneously, significantly different levels of CD1d on monocytes were identified between the CR‑AML and the CR‑ALL patients; the levels of CD1d on monocytes remained low in the CR‑AML patients, while the levels of CD1d on monocytes recovered in the CR‑ALL patients. A significantly negative correlation was observed between the number of CD3+CD56+ T lymphocytes and the levels of CD1d on monocytes in AL patients. However, a significantly positive correlation was identified between the cytotoxicity of the CD3+CD56+ T lymphocytes and the levels of CD1d on monocytes. These results suggested that the significantly low levels of CD1d on monocytes may contribute to AML and ALL progression. In addition, a significant correlation was observed between the levels of CD1d on monocytes and the number/cytotoxicity of CD3+CD56+ T lymphocytes in AML and ALL patients.
View Figures

Figure 1

Figure 2

View References

1 

Mellman I, Coukos G and Dranoff G: Cancer immunotherapy comes of age. Nature. 480:480–489. 2011.

2 

Bennett JM, Catovsky D, Daniel MT, et al: Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group. Br J Haematol. 33:451–458. 1976.

3 

Horowitz MM, Gale RP, Sondel PM, et al: Graft-versus-leukemia reactions after bone marrow transplantation. Blood. 75:555–562. 1990.

4 

Görgün G, Holderried TA, Zahrieh D, Neuberg D and Gribben JG: Chronic lymphocytic leukemia cells induce changes in gene expression of CD4 and CD8 T cells. J Clin Invest. 115:1797–1805. 2005.

5 

Görgün G, Ramsay AG, Holderried TA, et al: E(mu)-TCL1 mice represent a model for immunotherapeutic reversal of chronic lymphocytic leukemia-induced T-cell dysfunction. Proc Natl Acad Sci USA. 106:6250–6255. 2009.

6 

Dustin ML and Cooper JA: The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling. Nat Immunol. 1:23–29. 2000.

7 

Ramsay AG, Johnson AJ, Lee AM, et al: Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug. J Clin Invest. 118:2427–2437. 2008.

8 

Godfrey DI, Hammond KJ, Poulton LD, Smyth MJ and Baxter AG: NKT cells: facts, functions and fallacies. Immunol Today. 21:573–583. 2000.

9 

Joyce S: CD1d and natural T cells: how their properties jump-start the immune system. Cell Mol Life Sci. 58:442–469. 2001.

10 

Pittet MJ, Speiser DE, Valmori D, Cerottini JC and Romero P: Cutting edge: cytolytic effector function in human circulating CD8+ T cells closely correlates with CD56 surface expression. J Immunol. 164:1148–1152. 2000.

11 

Ohkawa T, Seki S, Dobashi H, et al: Systematic characterization of human CD8+ T cells with natural killer cell markers in comparison with natural killer cells and normal CD8+ T cells. Immunology. 103:281–290. 2001.

12 

Kronenberg M: Toward an understanding of NKT cell biology: progress and paradoxes. Annu Rev Immunol. 23:877–900. 2005.

13 

Bendelac A, Savage PB and Teyton L: The biology of NKT cells. Annu Rev Immunol. 25:297–336. 2007.

14 

Taniguchi M, Tashiro T, Dashtsoodol N, Hongo N and Watarai H: The specialized iNKT cell system recognizes glycolipid antigens and bridges the innate and acquired immune systems with potential applications for cancer therapy. Int Immunol. 22:1–6. 2010.

15 

Godfrey DI and Kronenberg M: Going both ways: immune regulation via NKT cells. J Clin Inv. 114:13792004.

16 

Van der Vliet HJ, Molling JW, von Blomberg BM, et al: The immunoregulatory role of CD1d-restricted natural killer T cells in disease. Clin Immunol. 112:8–23. 2004.

17 

Nowak M and Stein-Streilein J: Invariant NKT cells and tolerance. Int Rev Immunol. 26:95–119. 2007.

18 

Matsuda JL, Mallevaey T, Scott-Browne J and Gapin L: CD1d-restricted iNKT cells, the ‘Swiss-Army knife’ of the immune system. Curr Opin Immunol. 20:358–368. 2008.

19 

Parekh VV, Wilson MT and Van Kaer L: iNKT-cell responses to glycolipids. CritRevImmunol. 25:183–213. 2005.

20 

Salio M, Silk JD and Cerundolo V: Recent advances in processing and presentation of CD1 bound lipid antigens. Curr Opin Immunol. 22:81–88. 2010.

21 

Venkataswamy MM and Porcelli SA: Lipid and glycolipid antigens of CD1d-restricted natural killer T cells. Semin Immunol. 22:68–78. 2010.

22 

Swann JB, Coquet JM, Smyth MJ and Godfrey DI: CD1-restricted T cells and tumor immunity. Curr Top Microbiol Immunol. 314:293–323. 2007.

23 

Berzofsky JA and Terabe M: The contrasting roles of NKT cells in tumor immunity. Curr Mol Med. 9:667–672. 2009.

24 

Dhodapkar MV: Harnessing human CD1d restricted T cells for tumor immunity: progress and challenges. Front Biosci. 14:796–807. 2009.

25 

Hegde S, Fox L, Wang X and Gumperz JE: Autoreactive natural killer T cells: promoting immune protection and immune tolerance through varied interactions with myeloid antigen-presenting cells. Immunology. 130:471–483. 2010.

26 

Exley M, Garcia J, Wilson SB, et al: CD1d structure and regulation on human thymocytes, peripheral blood T cells, B cells and monocytes. Immunology. 100:37–47. 2000.

27 

Kitamura H, Iwakabe K, Yahata T, et al: The natural killer T(NKT) cell ligand alpha-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells. J Exp Med. 189:1121–1128. 1999.

28 

Tomura M, Yu WG, Ahn HJ, et al: A novel function of Valpha14+CD4+NKT cells: stimulation of IL-12 production by antigen-presenting cells in the innate immune system. J Immunol. 163:93–101. 1999.

29 

Hayakawa Y, Takeda K, Yagita H, et al: Differential regulation of Th1 and Th2 functions of NKT cells by CD28 and CD40 costimulatory pathways. J Immunol. 166:6012–6018. 2001.

30 

Berzins SP, Smyth MJ and Baxter AG: Presumed guilty: natural killer T cell defects and human disease. Nat Rev Immunol. 11:131–142. 2011.

31 

Troy AJ, Summers KL, Davidson PJT, Atkinson CH and Hart DNJ: Minimal recruitment and activation of dendritic cells within renal cell carcinoma. Clin Cancer Res. 4:585–593. 1998.

32 

Enk AH, Jonuleit H, Saloga J and Knop J: Dendritic cells as mediators of tumor-induced tolerance in metastatic melanoma. Int J Cancer. 73:309–316. 1997.

33 

Nestle FO, Burg G, Fäh J, Wrone-Smith T and Nickoloff BJ: Human sunlight-induced basal-cell-carcinoma-associated dendritic cells are deficient in T cell co-stimulatory molecules and are impaired as antigen-presenting cells. Am J Pathol. 150:641–651. 1997.

34 

Gabrilovich DI, Corak J, Ciernik IF, Kavanaugh D and Carbone DP: Decreased antigen presentation by dendritic cells in patients with breast cancer. Clin Cancer Res. 3:483–490. 1997.

35 

Guo W, Xing C, Dong A, et al: Numbers and cytotoxicities of CD3+CD56+ T lymphocytes in peripheral blood of patients with acute myeloid leukemia and acute lymphocytic leukemia. Cancer Biol Ther. 14:916–921. 2013.

36 

Spada FM, Borriello F, Sugita M, et al: Low expression level but potent antigen presenting function of CD1d on monocyte lineage cells. Eur J Immunol. 30:3468–77. 2000.

37 

Kurts C, Robinson BW and Knolle PA: Cross-priming in health and disease. Nat Rev Immunol. 10:403–414. 2010.

38 

Matzinger P: The danger model: a renewed sense of self. Science. 296:301–5. 2002.

39 

Burgdorf S, Schölz C, Kautz A, Tampé R and Kurts C: Spatial and mechanistic separation of cross-presentation endogenous antigen presentation. Nature Immunology. 9:558–566. 2008.

40 

East JE, Sun W and Webb TJ: Artificial antigen presenting cell (aAPC) mediated activation and expansion of natural killer T cells. J Vis Exp. 29:43332012.

41 

Webb TJ, Bieler JG, Schneck JP and Oelke M: Ex vivo induction and expansion of natural killer T cells by CD1d1-Ig coated artificial antigen presenting cells. J Immunol Methods. 31:38–44. 2009.

42 

Webb TJ, Giuntoli RL II, Rogers O, Schneck J and Oelke M: Ascites specific inhibition of CD1d-mediated activation of natural killer T cells. Clin Cancer Res. 1:7652–7658. 2008.

43 

Inaba H, Greaves M and Mullighan CG: Acute lymphoblastic leukaemia. Lancet. 381:1943–1955. 2013.

44 

Fais F, Tenca C, Cimino G, et al: CD1d expression on B-precursor acute lymphoblastic leukemia subsets with poor prognosis. Leukemia. 19:551–556. 2005.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Guo W, Dong A, Xing C, Lin X, Pan X, Lin Y, Zhu B, He M and Yao RX: CD1d levels in peripheral blood of patients with acute myeloid leukemia and acute lymphoblastic leukemia. Oncol Lett 8: 825-830, 2014.
APA
Guo, W., Dong, A., Xing, C., Lin, X., Pan, X., Lin, Y. ... Yao, R. (2014). CD1d levels in peripheral blood of patients with acute myeloid leukemia and acute lymphoblastic leukemia. Oncology Letters, 8, 825-830. https://doi.org/10.3892/ol.2014.2208
MLA
Guo, W., Dong, A., Xing, C., Lin, X., Pan, X., Lin, Y., Zhu, B., He, M., Yao, R."CD1d levels in peripheral blood of patients with acute myeloid leukemia and acute lymphoblastic leukemia". Oncology Letters 8.2 (2014): 825-830.
Chicago
Guo, W., Dong, A., Xing, C., Lin, X., Pan, X., Lin, Y., Zhu, B., He, M., Yao, R."CD1d levels in peripheral blood of patients with acute myeloid leukemia and acute lymphoblastic leukemia". Oncology Letters 8, no. 2 (2014): 825-830. https://doi.org/10.3892/ol.2014.2208
Copy and paste a formatted citation
x
Spandidos Publications style
Guo W, Dong A, Xing C, Lin X, Pan X, Lin Y, Zhu B, He M and Yao RX: CD1d levels in peripheral blood of patients with acute myeloid leukemia and acute lymphoblastic leukemia. Oncol Lett 8: 825-830, 2014.
APA
Guo, W., Dong, A., Xing, C., Lin, X., Pan, X., Lin, Y. ... Yao, R. (2014). CD1d levels in peripheral blood of patients with acute myeloid leukemia and acute lymphoblastic leukemia. Oncology Letters, 8, 825-830. https://doi.org/10.3892/ol.2014.2208
MLA
Guo, W., Dong, A., Xing, C., Lin, X., Pan, X., Lin, Y., Zhu, B., He, M., Yao, R."CD1d levels in peripheral blood of patients with acute myeloid leukemia and acute lymphoblastic leukemia". Oncology Letters 8.2 (2014): 825-830.
Chicago
Guo, W., Dong, A., Xing, C., Lin, X., Pan, X., Lin, Y., Zhu, B., He, M., Yao, R."CD1d levels in peripheral blood of patients with acute myeloid leukemia and acute lymphoblastic leukemia". Oncology Letters 8, no. 2 (2014): 825-830. https://doi.org/10.3892/ol.2014.2208
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team