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Review Open Access

The paediatric story of human papillomavirus (Review)

  • Authors:
    • Ioannis N. Mammas
    • George Sourvinos
    • Demetrios A. Spandidos
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Virology, School of Medicine, University of Crete, Heraklion 71003, Greece
  • Pages: 502-506
    |
    Published online on: June 4, 2014
       https://doi.org/10.3892/ol.2014.2226
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Abstract

Human papillomavirus (HPV) is composed of a particularly heterogeneous family of DNA viruses, which has gained much attention in recent years due to the discoveries of Professor Harald zur Hausen, who first identified a connection between HPV and cervical cancer. Professor Harald zur Hausen, the ‘Father of HPV Virology’, was the recipient of the 2008 Nobel Prize. HPV can be transmitted through physical contact via autoinoculation or fomites, sexual contact, as well as vertically from the HPV-positive mother to her newborn, causing subclinical or clinical infections. In infancy and childhood, HPV-associated clinical infections include skin warts, genital warts and juvenile recurrent respiratory papillomatosis, while cervical squamous intraepithelial lesions have also been reported among adolescent girls. To date, several research teams, worldwide, have extensively investigated HPV from the paediatric point of view. This primitive effort has been performed before the recent great expansion of paediatric HPV research due to the vaccination programmes against HPV, which were introduced into clinical practice in 2006. In this review article, we present a brief overview of paediatric HPV research after the first report in 1978 involving children in the research of HPV until the time point of this great expansion. In the future, it is expected that further unresolved issues will be addressed and clarified, as the paediatric story of HPV remains a challenging research target.
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Spandidos Publications style
Mammas IN, Sourvinos G and Spandidos DA: The paediatric story of human papillomavirus (Review). Oncol Lett 8: 502-506, 2014.
APA
Mammas, I.N., Sourvinos, G., & Spandidos, D.A. (2014). The paediatric story of human papillomavirus (Review). Oncology Letters, 8, 502-506. https://doi.org/10.3892/ol.2014.2226
MLA
Mammas, I. N., Sourvinos, G., Spandidos, D. A."The paediatric story of human papillomavirus (Review)". Oncology Letters 8.2 (2014): 502-506.
Chicago
Mammas, I. N., Sourvinos, G., Spandidos, D. A."The paediatric story of human papillomavirus (Review)". Oncology Letters 8, no. 2 (2014): 502-506. https://doi.org/10.3892/ol.2014.2226
Copy and paste a formatted citation
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Spandidos Publications style
Mammas IN, Sourvinos G and Spandidos DA: The paediatric story of human papillomavirus (Review). Oncol Lett 8: 502-506, 2014.
APA
Mammas, I.N., Sourvinos, G., & Spandidos, D.A. (2014). The paediatric story of human papillomavirus (Review). Oncology Letters, 8, 502-506. https://doi.org/10.3892/ol.2014.2226
MLA
Mammas, I. N., Sourvinos, G., Spandidos, D. A."The paediatric story of human papillomavirus (Review)". Oncology Letters 8.2 (2014): 502-506.
Chicago
Mammas, I. N., Sourvinos, G., Spandidos, D. A."The paediatric story of human papillomavirus (Review)". Oncology Letters 8, no. 2 (2014): 502-506. https://doi.org/10.3892/ol.2014.2226
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