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Article

Cathepsin D serum and urine concentration in superficial and invasive transitional bladder cancer as determined by surface plasmon resonance imaging

  • Authors:
    • Ewa Gorodkiewicz
    • Tomasz Guszcz
    • Wieslawa  Roszkowska‑Jakimiec
    • Robert Kozłowski
  • View Affiliations / Copyright

    Affiliations: Department of Electrochemistry, Institute of Chemistry, University of Bialystok, Bialystok PL‑15‑443, Poland, Department of Urology, J. Sniadecki Provincial Hospital of Bialystok, Bialystok PL‑15‑950, Poland, Department of Analytical Chemistry, Medical University of Bialystok, Bialystok PL‑15‑230, Poland
  • Pages: 1323-1327
    |
    Published online on: June 12, 2014
       https://doi.org/10.3892/ol.2014.2250
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Abstract

Determination of cathepsin D (Cat D) concentration in serum and urine may be useful in the diagnosis of bladder cancer. The present study included 54 healthy patients and 68 patients with bladder cancer, confirmed by transurethral resection or cystectomy. Cat D concentration was determined using a surface plasmon resonance imaging biosensor. Cat D concentration in the serum of bladder cancer patients was within the range of 1.3‑5.59 ng/ml, while for healthy donors it was within the range of 0.28‑0.52 ng/ml. In urine, the Cat D concentration of bladder cancer patients was within the range of 1.35‑7.14 ng/ml, while for healthy donors it was within the range of 0.32‑0.68 ng/ml. Cat D concentration may represent an efficient tumor marker, as its concentration in the serum and urine of transitional cell carcinoma patients is extremely high when compared with healthy subjects.
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Copy and paste a formatted citation
Spandidos Publications style
Gorodkiewicz E, Guszcz T, Roszkowska‑Jakimiec W and Kozłowski R: Cathepsin D serum and urine concentration in superficial and invasive transitional bladder cancer as determined by surface plasmon resonance imaging. Oncol Lett 8: 1323-1327, 2014.
APA
Gorodkiewicz, E., Guszcz, T., Roszkowska‑Jakimiec, W., & Kozłowski, R. (2014). Cathepsin D serum and urine concentration in superficial and invasive transitional bladder cancer as determined by surface plasmon resonance imaging. Oncology Letters, 8, 1323-1327. https://doi.org/10.3892/ol.2014.2250
MLA
Gorodkiewicz, E., Guszcz, T., Roszkowska‑Jakimiec, W., Kozłowski, R."Cathepsin D serum and urine concentration in superficial and invasive transitional bladder cancer as determined by surface plasmon resonance imaging". Oncology Letters 8.3 (2014): 1323-1327.
Chicago
Gorodkiewicz, E., Guszcz, T., Roszkowska‑Jakimiec, W., Kozłowski, R."Cathepsin D serum and urine concentration in superficial and invasive transitional bladder cancer as determined by surface plasmon resonance imaging". Oncology Letters 8, no. 3 (2014): 1323-1327. https://doi.org/10.3892/ol.2014.2250
Copy and paste a formatted citation
x
Spandidos Publications style
Gorodkiewicz E, Guszcz T, Roszkowska‑Jakimiec W and Kozłowski R: Cathepsin D serum and urine concentration in superficial and invasive transitional bladder cancer as determined by surface plasmon resonance imaging. Oncol Lett 8: 1323-1327, 2014.
APA
Gorodkiewicz, E., Guszcz, T., Roszkowska‑Jakimiec, W., & Kozłowski, R. (2014). Cathepsin D serum and urine concentration in superficial and invasive transitional bladder cancer as determined by surface plasmon resonance imaging. Oncology Letters, 8, 1323-1327. https://doi.org/10.3892/ol.2014.2250
MLA
Gorodkiewicz, E., Guszcz, T., Roszkowska‑Jakimiec, W., Kozłowski, R."Cathepsin D serum and urine concentration in superficial and invasive transitional bladder cancer as determined by surface plasmon resonance imaging". Oncology Letters 8.3 (2014): 1323-1327.
Chicago
Gorodkiewicz, E., Guszcz, T., Roszkowska‑Jakimiec, W., Kozłowski, R."Cathepsin D serum and urine concentration in superficial and invasive transitional bladder cancer as determined by surface plasmon resonance imaging". Oncology Letters 8, no. 3 (2014): 1323-1327. https://doi.org/10.3892/ol.2014.2250
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