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miR‑320a is an independent prognostic biomarker for invasive breast cancer

  • Authors:
    • Haiping Yang
    • Juan Yu
    • Lei Wang
    • Di Ding
    • Lei Zhang
    • Chengyu Chu
    • Qi Chen
    • Zude Xu
    • Qiang Zou
    • Xiuping Liu
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, P.R. China, Department of Surgery, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China
  • Pages: 1043-1050
    |
    Published online on: June 30, 2014
       https://doi.org/10.3892/ol.2014.2298
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Abstract

Breast cancer is one of the most common malignancies worldwide and is the second leading cause of cancer‑related mortality among females. miRNAs are a class of small noncoding RNAs that are aberrantly expressed in human cancers. Due to their small size and stability, miRNAs have the potential to be efficacious clinical targets. MicroRNA‑320a (miR‑320a) has been shown to be dysregulated in multiple malignancies. In the present study, the expression levels of miR‑320a were investigated in 15 paraffin‑embedded in situ breast carcinoma and 130 invasive breast cancer tissues, and the prognostic value for breast cancer patients was assessed. Chromogenic in situ hybridization revealed that 60/130 (46%) invasive breast cancer tissues exhibited high expression levels of miR‑320a (staining index score of ≥4). Furthermore, miR‑320a staining was found to significantly correlate with tumor size (P=0.046), clinical stage (P<0.001), lymph node metastasis (P<0.001) and distant metastasis (P=0.006). In addition, patients exhibiting low miR‑320a expression levels had shorter overall survival times (P<0.001). Univariate and multivariate analyses revealed that miR‑320a was an independent prognostic biomarker for invasive breast cancer (hazard ratio, 0.221; 95% confidence interval, 0.050‑0.979; P=0.047). Receiver operator characteristic curves revealed that the prognostic value of miR‑320a was enhanced when compared with the widely used prognostic biomarkers (estrogen receptor, progesterone receptor and human epidermal growth factor‑2) in invasive breast cancer. The results of the present study suggest that miR‑320a presents a potential biomarker for the prognosis of invasive breast cancer, and dysregulation of miR‑320a may be involved in invasive breast cancer progression.
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1 

Yu G, Liu G, Dong J and Jin Y: Clinical implications of CIP2A protein expression in breast cancer. Med Oncol. 30:5242013.

2 

Wu ZS, Wu Q, Wang CQ, et al: MiR-339-5p inhibits breast cancer cell migration and invasion in vitro and may be a potential biomarker for breast cancer prognosis. BMC Cancer. 10:5422010.

3 

Hanna JA, Hahn L, Agarwal S and Rimm DL: In situ measurement of miR-205 in malignant melanoma tissue supports its role as a tumor suppressor microRNA. Lab Invest. 92:1390–1397. 2012.

4 

Shenouda SK and Alahari SK: MicroRNA function in cancer: oncogene or a tumor suppressor? Cancer Metast Rev. 28:369–378. 2009.

5 

Wu W, Takanashi M, Borjigin N, et al: MicroRNA-18a modulates STAT3 activity through negative regulation of PIAS3 during gastric adenocarcinogenesis. Br J Cancer. 108:653–661. 2013.

6 

Wu ZS, Wu Q, Wang CQ, et al: miR-340 inhibition of breast cancer cell migration and invasion through targeting of oncoprotein c-Met. Cancer. 117:2842–2852. 2011.

7 

Zhang B, Pan X, Cobb GP and Anderson TA: microRNAs as oncogenes and tumor suppressors. Dev Biol. 302:1–12. 2007.

8 

Welch C, Chen Y and Stallings RL: MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells. Oncogene. 26:5017–5022. 2007.

9 

Gartel AL and Kandel ES: miRNAs: Little known mediators of oncogenesis. Semin Cancer Biol. 18:103–110. 2008.

10 

Sun JY, Huang Y, Li JP, et al: MicroRNA-320a suppresses human colon cancer cell proliferation by directly targeting β-catenin. Biochem Biophys Res Commun. 420:787–792. 2012.

11 

Zhang Y, He X, Liu Y, et al: microRNA-320a inhibits tumor invasion by targeting neuropilin 1 and is associated with liver metastasis in colorectal cancer. Oncol Rep. 27:685–694. 2012.

12 

Xu G, Wu J, Zhou L, et al: Characterization of the small RNA transcriptomes of androgen dependent and independent prostate cancer cell line by deep sequencing. PLoS One. 5:e155192010.

13 

Xu Q, Dong QG, Sun LP, et al: Expression of serum miR-20a-5p, let-7a, and miR-320a and their correlations with pepsinogen in atrophic gastritis and gastric cancer: a case-control study. BMC Clin Pathol. 13:112013.

14 

Tavassoli FA and Devilee P: World Heatlh Organization Classification of Tumours. Pathology and Genetics, Tumors of the Breast and Female Genital Organs. IARC Press; Lyon: pp. 102003

15 

Allred DC, Wu Y, Mao S, et al: Ductal carcinoma in situ and the emergence of diversity during breast cancer evolution. Clin Cancer Res. 14:370–378. 2008.

16 

Tang W, Zhu J, Su S, et al: MiR-27 as a prognostic marker for breast cancer progression and patient survival. PLoS One. 7:e517022012.

17 

Nie Y, Liu X, Qu S, et al: Long non-coding RNA HOTAIR is an independent prognostic marker for nasopharyngeal carcinoma progression and survival. Cancer Sci. 104:458–464. 2013.

18 

Cao XX, Xu JD, Liu XL, et al: RACK1: A superior independent predictor for poor clinical outcome in breast cancer. Int J Cancer. 127:1172–1179. 2010.

19 

Dillhoff M, Liu J, Frankel W, et al: MicroRNA-21 is overexpressed in pancreatic cancer and a potential predictor of survival. J Gastrointest Surg. 12:2171–2176. 2008.

20 

Diakos C, Zhong S, Xiao Y, et al: TEL-AML1 regulation of survivin and apoptosis via miRNA-494 and miRNA-320a. Blood. 116:4885–4893. 2010.

21 

Hummel R, Wang T, Watson DI, et al: Chemotherapy-induced modification of microRNA expression in esophageal cancer. Oncol Rep. 26:1011–1017. 2011.

22 

Salendo J, Spitzner M, Kramer F, et al: Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a, -224, -132 and let7g. Radiother Oncol. 108:451–457. 2013.

23 

Yu H, Giai M, Diamandis EP, et al: Prostate-specific antigen is a new favorable prognostic indicator for women with breast cancer. Cancer Res. 55:2104–2110. 1995.

24 

Crowe JP, Hubay CA, Pearson OH, et al: Estrogen receptor status as a prognostic indicator for stage I breast cancer patients. Breast Cancer Res Treat. 2:171–176. 1982.

25 

Marty M, Cognetti F, Maraninchi D, et al: Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: the M77001 study group. J Clin Oncol. 23:4265–4274. 2005.

26 

Horiguchi J, Iino Y, Takei H, et al: c-erbB-2 status is an independent predictor of survival after first recurrence. Int J Oncol. 12:123–128. 1998.

27 

Wu Y, Khan H, Chillar R and Vadgama JV: Prognostic value of plasma HER-2/neu in African American and Hispanic women with breast cancer. Int J Oncol. 14:1021–1037. 1999.

28 

Fagerholm R, Sprott K, Heikkinen T, et al: Overabundant FANCD2, alone and combined with NQO1, is a sensitive marker of adverse prognosis in breast cancer. Ann Oncol. 24:2780–2785. 2013.

29 

Chang J, Clark GM, Allred DC, et al: Survival of patients with metastatic breast carcinoma: importance of prognostic markers of the primary tumor. Cancer. 97:545–553. 2003.

30 

Hall JS, Taylor J, Valentine HR, et al: Enhanced stability of microRNA expression facilitates classification of FFPE tumour samples exhibiting near total mRNA degradation. Br J Cancer. 107:684–694. 2012.

31 

Jung M, Schaefer A, Steiner I, et al: Robust microRNA stability in degraded RNA preparations from human tissue and cell samples. Clin Chem. 56:998–1006. 2010.

32 

Ma Y, Zhang P, Wang F, et al: miR-150 as a potential biomarker associated with prognosis and therapeutic outcome in colorectal cancer. Gut. 61:1447–1453. 2012.

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Copy and paste a formatted citation
Spandidos Publications style
Yang H, Yu J, Wang L, Ding D, Zhang L, Chu C, Chen Q, Xu Z, Zou Q, Liu X, Liu X, et al: miR‑320a is an independent prognostic biomarker for invasive breast cancer. Oncol Lett 8: 1043-1050, 2014.
APA
Yang, H., Yu, J., Wang, L., Ding, D., Zhang, L., Chu, C. ... Liu, X. (2014). miR‑320a is an independent prognostic biomarker for invasive breast cancer. Oncology Letters, 8, 1043-1050. https://doi.org/10.3892/ol.2014.2298
MLA
Yang, H., Yu, J., Wang, L., Ding, D., Zhang, L., Chu, C., Chen, Q., Xu, Z., Zou, Q., Liu, X."miR‑320a is an independent prognostic biomarker for invasive breast cancer". Oncology Letters 8.3 (2014): 1043-1050.
Chicago
Yang, H., Yu, J., Wang, L., Ding, D., Zhang, L., Chu, C., Chen, Q., Xu, Z., Zou, Q., Liu, X."miR‑320a is an independent prognostic biomarker for invasive breast cancer". Oncology Letters 8, no. 3 (2014): 1043-1050. https://doi.org/10.3892/ol.2014.2298
Copy and paste a formatted citation
x
Spandidos Publications style
Yang H, Yu J, Wang L, Ding D, Zhang L, Chu C, Chen Q, Xu Z, Zou Q, Liu X, Liu X, et al: miR‑320a is an independent prognostic biomarker for invasive breast cancer. Oncol Lett 8: 1043-1050, 2014.
APA
Yang, H., Yu, J., Wang, L., Ding, D., Zhang, L., Chu, C. ... Liu, X. (2014). miR‑320a is an independent prognostic biomarker for invasive breast cancer. Oncology Letters, 8, 1043-1050. https://doi.org/10.3892/ol.2014.2298
MLA
Yang, H., Yu, J., Wang, L., Ding, D., Zhang, L., Chu, C., Chen, Q., Xu, Z., Zou, Q., Liu, X."miR‑320a is an independent prognostic biomarker for invasive breast cancer". Oncology Letters 8.3 (2014): 1043-1050.
Chicago
Yang, H., Yu, J., Wang, L., Ding, D., Zhang, L., Chu, C., Chen, Q., Xu, Z., Zou, Q., Liu, X."miR‑320a is an independent prognostic biomarker for invasive breast cancer". Oncology Letters 8, no. 3 (2014): 1043-1050. https://doi.org/10.3892/ol.2014.2298
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