Open Access

miR‑320a is an independent prognostic biomarker for invasive breast cancer

  • Authors:
    • Haiping Yang
    • Juan Yu
    • Lei Wang
    • Di Ding
    • Lei Zhang
    • Chengyu Chu
    • Qi Chen
    • Zude Xu
    • Qiang Zou
    • Xiuping Liu
  • View Affiliations

  • Published online on: June 30, 2014     https://doi.org/10.3892/ol.2014.2298
  • Pages: 1043-1050
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Abstract

Breast cancer is one of the most common malignancies worldwide and is the second leading cause of cancer‑related mortality among females. miRNAs are a class of small noncoding RNAs that are aberrantly expressed in human cancers. Due to their small size and stability, miRNAs have the potential to be efficacious clinical targets. MicroRNA‑320a (miR‑320a) has been shown to be dysregulated in multiple malignancies. In the present study, the expression levels of miR‑320a were investigated in 15 paraffin‑embedded in situ breast carcinoma and 130 invasive breast cancer tissues, and the prognostic value for breast cancer patients was assessed. Chromogenic in situ hybridization revealed that 60/130 (46%) invasive breast cancer tissues exhibited high expression levels of miR‑320a (staining index score of ≥4). Furthermore, miR‑320a staining was found to significantly correlate with tumor size (P=0.046), clinical stage (P<0.001), lymph node metastasis (P<0.001) and distant metastasis (P=0.006). In addition, patients exhibiting low miR‑320a expression levels had shorter overall survival times (P<0.001). Univariate and multivariate analyses revealed that miR‑320a was an independent prognostic biomarker for invasive breast cancer (hazard ratio, 0.221; 95% confidence interval, 0.050‑0.979; P=0.047). Receiver operator characteristic curves revealed that the prognostic value of miR‑320a was enhanced when compared with the widely used prognostic biomarkers (estrogen receptor, progesterone receptor and human epidermal growth factor‑2) in invasive breast cancer. The results of the present study suggest that miR‑320a presents a potential biomarker for the prognosis of invasive breast cancer, and dysregulation of miR‑320a may be involved in invasive breast cancer progression.
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September-2014
Volume 8 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Yang H, Yu J, Wang L, Ding D, Zhang L, Chu C, Chen Q, Xu Z, Zou Q, Liu X, Liu X, et al: miR‑320a is an independent prognostic biomarker for invasive breast cancer. Oncol Lett 8: 1043-1050, 2014
APA
Yang, H., Yu, J., Wang, L., Ding, D., Zhang, L., Chu, C. ... Liu, X. (2014). miR‑320a is an independent prognostic biomarker for invasive breast cancer. Oncology Letters, 8, 1043-1050. https://doi.org/10.3892/ol.2014.2298
MLA
Yang, H., Yu, J., Wang, L., Ding, D., Zhang, L., Chu, C., Chen, Q., Xu, Z., Zou, Q., Liu, X."miR‑320a is an independent prognostic biomarker for invasive breast cancer". Oncology Letters 8.3 (2014): 1043-1050.
Chicago
Yang, H., Yu, J., Wang, L., Ding, D., Zhang, L., Chu, C., Chen, Q., Xu, Z., Zou, Q., Liu, X."miR‑320a is an independent prognostic biomarker for invasive breast cancer". Oncology Letters 8, no. 3 (2014): 1043-1050. https://doi.org/10.3892/ol.2014.2298