Mechanisms of coagulative necrosis in malignant epithelial tumors (Review)

  • Authors:
    • Rosario A. Caruso
    • Giovanni Branca
    • Francesco Fedele
    • Eleonora  Irato
    • Giuseppe  Finocchiaro
    • Antonio Parisi
    • Antonio Ieni
  • View Affiliations

  • Published online on: July 11, 2014     https://doi.org/10.3892/ol.2014.2345
  • Pages: 1397-1402
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Histological tumor necrosis (TN) has been reported to indicate a poor prognosis for different human cancers. It is generally accepted that TN results from chronic ischemic injury due to rapid tumor growth. However, whether insufficient tumor vascularization and inadequate tumor cell oxygenation are the only factors causing TN remains controversial. Mitotic catastrophe is considered to occur as a result of dysregulated/failed mitosis, leading to cell death. We hypothesize that mitotic catastrophe, induced by hypoxic stress, may lead to the TN which is observed in high grade carcinomas. The current review describes the morphological features of TN in malignant epithelial tumors. In addition, evidence regarding the involvement of mitotic catastrophe in the induction of TN in human carcinomas is discussed.
View Figures
View References

Related Articles

Journal Cover

October 2014
Volume 8 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Caruso RA, Branca G, Fedele F, Irato E, Finocchiaro G, Parisi A and Ieni A: Mechanisms of coagulative necrosis in malignant epithelial tumors (Review). Oncol Lett 8: 1397-1402, 2014.
APA
Caruso, R.A., Branca, G., Fedele, F., Irato, E., Finocchiaro, G., Parisi, A., & Ieni, A. (2014). Mechanisms of coagulative necrosis in malignant epithelial tumors (Review). Oncology Letters, 8, 1397-1402. https://doi.org/10.3892/ol.2014.2345
MLA
Caruso, R. A., Branca, G., Fedele, F., Irato, E., Finocchiaro, G., Parisi, A., Ieni, A."Mechanisms of coagulative necrosis in malignant epithelial tumors (Review)". Oncology Letters 8.4 (2014): 1397-1402.
Chicago
Caruso, R. A., Branca, G., Fedele, F., Irato, E., Finocchiaro, G., Parisi, A., Ieni, A."Mechanisms of coagulative necrosis in malignant epithelial tumors (Review)". Oncology Letters 8, no. 4 (2014): 1397-1402. https://doi.org/10.3892/ol.2014.2345