Elastography, a sensitive tool for the evaluation of neoadjuvant chemotherapy in patients with high‑grade serous ovarian carcinoma

Xie,Meng; Zhang,Xuyin; Jia,Zhan; Ren,Yunyun; Wang,Wenping

doi:10.3892/ol.2014.2346

October 2014 Volume 8 Issue 4

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October 2014 Volume 8 Issue 4

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Article

Elastography, a sensitive tool for the evaluation of neoadjuvant chemotherapy in patients with high‑grade serous ovarian carcinoma

Authors:
- Meng Xie
- Xuyin Zhang
- Zhan Jia
- Yunyun Ren
- Wenping Wang
View Affiliations / Copyright

Affiliations: Department of Ultrasound, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200090, P.R. China, Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200090, P.R. China, Department of Ultrasound, Huadong Hospital, Fudan University, Shanghai 200050, P.R. China, Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China
Pages: 1652-1656
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Published online on: July 11, 2014

https://doi.org/10.3892/ol.2014.2346
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Abstract

The aim of the present study was to evaluate tumor stiffness by ultrasound elastography, which has the potential to provide additional information that is useful in predicting the response to neoadjuvant chemotherapy (NACT) in high‑grade serous ovarian carcinoma (HGSC) patients. In total, 32 patients with International Federation of Gynecology and Obstetrics stage III and IV epithelial ovarian cancer treated with NACT underwent transvaginal and transabdominal sonography, followed by elastography and finally, by interval cytoreductive surgery. Histopathological analysis revealed 24 (75%) HGSCs. The mean elasticity score was statistically higher for the post‑NACT lesions than for the pre‑NACT lesions (3.13±0.57 vs. 2.04±0.51, respectively; P<0.001). The median elasticity score for the pre‑NACT lesions on the four‑point scale was 2, and the score for the post‑NACT lesions was 4. Cases of post‑NACT with scores of 3 and 4 had a higher optimal cytoreduction rate than cases with scores of 1 and 2 (93.8 vs. 25.0%, respectively; P<0.001). When the post‑NACT elasticity scores of 3 and 4 were used for the prediction of optimal cytoreduction, elastography exhibited 88.2% sensitivity, 85.7% specificity, a 93.8% positive predictive value, a 75.0% negative predictive value and 87.5% accuracy. The results of the current study suggested that elastography is a sensitive tool for the evaluation of NACT in patients with HGSC and that it may aid gynecologists in choosing the optimal cytoreduction.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Elastography, a sensitive tool for the evaluation of neoadjuvant chemotherapy in patients with high‑grade serous ovarian carcinoma

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