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Article

Alternative schedules or integration strategies to maximise treatment duration with sunitinib in patients with gastrointestinal stromal tumours

  • Authors:
    • Maristella Saponara
    • Cristian Lolli
    • Margherita Nannini
    • Valerio Di Scioscio
    • Carla Serra
    • Anna Mandrioli
    • Maria Caterina Pallotti
    • Guido Biasco
    • Maria Abbondanza Pantaleo
  • View Affiliations / Copyright

    Affiliations: Department of Specialized, Experimental and Diagnostic Medicine, S.Orsola-Malpighi Hospital, University of Bologna, Bologna 40138, Italy, Department of Radiology, S.Orsola‑Malpighi Hospital, University of Bologna, Bologna 40138, Italy, Department of Digestive Disease and Internal Medicine, S.Orsola‑Malpighi Hospital, University of Bologna, Bologna 40138, Italy
  • Pages: 1793-1799
    |
    Published online on: July 11, 2014
       https://doi.org/10.3892/ol.2014.2348
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Abstract

Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal tumour of the gastrointestinal tract. The advent of targeted kinase‑inhibitors has revolutionised treatment strategies and clinical outcomes for patients with advanced GIST. In the majority of countries, sunitinib is the only approved second‑line treatment option for advanced GIST patients, who are resistant or intolerant to imatinib. However, sunitinib is associated with various adverse events, which often result in a reduction of the dosage, and interruption or suspension of therapy. Effective therapy management is essential to obtain the maximum clinical benefit, and includes adequate side effect management as well as optimization of dosing and treatment duration. In the current study, examples of maximization of treatment with sunitinib are presented, describing three clinical cases in which therapy with sunitinib was continued via the adoption of alternative reduced schedules or an additional loco‑regional treatment, in order to manage toxicities or overcome progressive disease.
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Copy and paste a formatted citation
Spandidos Publications style
Saponara M, Lolli C, Nannini M, Di Scioscio V, Serra C, Mandrioli A, Pallotti MC, Biasco G and Pantaleo MA: Alternative schedules or integration strategies to maximise treatment duration with sunitinib in patients with gastrointestinal stromal tumours. Oncol Lett 8: 1793-1799, 2014.
APA
Saponara, M., Lolli, C., Nannini, M., Di Scioscio, V., Serra, C., Mandrioli, A. ... Pantaleo, M.A. (2014). Alternative schedules or integration strategies to maximise treatment duration with sunitinib in patients with gastrointestinal stromal tumours. Oncology Letters, 8, 1793-1799. https://doi.org/10.3892/ol.2014.2348
MLA
Saponara, M., Lolli, C., Nannini, M., Di Scioscio, V., Serra, C., Mandrioli, A., Pallotti, M. C., Biasco, G., Pantaleo, M. A."Alternative schedules or integration strategies to maximise treatment duration with sunitinib in patients with gastrointestinal stromal tumours". Oncology Letters 8.4 (2014): 1793-1799.
Chicago
Saponara, M., Lolli, C., Nannini, M., Di Scioscio, V., Serra, C., Mandrioli, A., Pallotti, M. C., Biasco, G., Pantaleo, M. A."Alternative schedules or integration strategies to maximise treatment duration with sunitinib in patients with gastrointestinal stromal tumours". Oncology Letters 8, no. 4 (2014): 1793-1799. https://doi.org/10.3892/ol.2014.2348
Copy and paste a formatted citation
x
Spandidos Publications style
Saponara M, Lolli C, Nannini M, Di Scioscio V, Serra C, Mandrioli A, Pallotti MC, Biasco G and Pantaleo MA: Alternative schedules or integration strategies to maximise treatment duration with sunitinib in patients with gastrointestinal stromal tumours. Oncol Lett 8: 1793-1799, 2014.
APA
Saponara, M., Lolli, C., Nannini, M., Di Scioscio, V., Serra, C., Mandrioli, A. ... Pantaleo, M.A. (2014). Alternative schedules or integration strategies to maximise treatment duration with sunitinib in patients with gastrointestinal stromal tumours. Oncology Letters, 8, 1793-1799. https://doi.org/10.3892/ol.2014.2348
MLA
Saponara, M., Lolli, C., Nannini, M., Di Scioscio, V., Serra, C., Mandrioli, A., Pallotti, M. C., Biasco, G., Pantaleo, M. A."Alternative schedules or integration strategies to maximise treatment duration with sunitinib in patients with gastrointestinal stromal tumours". Oncology Letters 8.4 (2014): 1793-1799.
Chicago
Saponara, M., Lolli, C., Nannini, M., Di Scioscio, V., Serra, C., Mandrioli, A., Pallotti, M. C., Biasco, G., Pantaleo, M. A."Alternative schedules or integration strategies to maximise treatment duration with sunitinib in patients with gastrointestinal stromal tumours". Oncology Letters 8, no. 4 (2014): 1793-1799. https://doi.org/10.3892/ol.2014.2348
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