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October 2014 Volume 8 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Significance of p85 expression as a prognostic factor for patients with breast cancer

  • Authors:
    • Weiwei Zhou
    • Guangyu An
    • Ping Wei
    • Wenming Chen
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Beijing Chao‑Yang Hospital, Capital Medical University, Beijing 100020, P.R. China, Department of Pathology, Beijing Chao‑Yang Hospital, Capital Medical University, Beijing 100020, P.R. China, Department of Hematology, Beijing Chao‑Yang Hospital, Capital Medical University, Beijing 100020, P.R. China
  • Pages: 1657-1661
    |
    Published online on: July 18, 2014
       https://doi.org/10.3892/ol.2014.2359
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Abstract

p85, the regulatory subunit of phosphatidylinositol 3‑kinase (PI3K), functions in the pathogenesis and progression of human breast cancers. Previous studies have observed that p85 isoforms may correlate with cancer cell proliferation. In the present study, immunohistochemical staining of p85 was performed in 126 primary breast cancers. The association between the expression levels of p85 with clinicopathological variables, subtypes and prognosis was studied. The breast cancer specimens were divided into three subgroups according to the expression levels of p85 protein. High p85 protein expression was significantly correlated with tumor grade, vascular invasion and recurrence and/or metastasis (P<0.05). Increased p85 protein expression was associated with the human epidermal growth factor receptor 2‑positive and triple‑negative breast cancers (P=0.008). Patients with higher p85 protein expression levels showed shorter disease‑free survival and overall survival times as compared with those with lower expression levels of p85 (P<0.001). Cox proportional‑hazards analysis showed that p85 protein expression was not an independent prognostic factor. Further large‑scale studies are required to evaluate the significance of p85 protein expression as a prognostic marker for breast cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou W, An G, Wei P and Chen W: Significance of p85 expression as a prognostic factor for patients with breast cancer. Oncol Lett 8: 1657-1661, 2014.
APA
Zhou, W., An, G., Wei, P., & Chen, W. (2014). Significance of p85 expression as a prognostic factor for patients with breast cancer. Oncology Letters, 8, 1657-1661. https://doi.org/10.3892/ol.2014.2359
MLA
Zhou, W., An, G., Wei, P., Chen, W."Significance of p85 expression as a prognostic factor for patients with breast cancer". Oncology Letters 8.4 (2014): 1657-1661.
Chicago
Zhou, W., An, G., Wei, P., Chen, W."Significance of p85 expression as a prognostic factor for patients with breast cancer". Oncology Letters 8, no. 4 (2014): 1657-1661. https://doi.org/10.3892/ol.2014.2359
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou W, An G, Wei P and Chen W: Significance of p85 expression as a prognostic factor for patients with breast cancer. Oncol Lett 8: 1657-1661, 2014.
APA
Zhou, W., An, G., Wei, P., & Chen, W. (2014). Significance of p85 expression as a prognostic factor for patients with breast cancer. Oncology Letters, 8, 1657-1661. https://doi.org/10.3892/ol.2014.2359
MLA
Zhou, W., An, G., Wei, P., Chen, W."Significance of p85 expression as a prognostic factor for patients with breast cancer". Oncology Letters 8.4 (2014): 1657-1661.
Chicago
Zhou, W., An, G., Wei, P., Chen, W."Significance of p85 expression as a prognostic factor for patients with breast cancer". Oncology Letters 8, no. 4 (2014): 1657-1661. https://doi.org/10.3892/ol.2014.2359
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