Curcumin inhibits vasculogenic mimicry through the downregulation of erythropoietin‑producing hepatocellular carcinoma‑A2, phosphoinositide 3‑kinase and matrix metalloproteinase‑2

  • Authors:
    • Yiming Liang
    • Min Huang
    • Jianwen Li
    • Xinlin Sun
    • Xiaodan Jiang
    • Liangping Li
    • Yiquan Ke
  • View Affiliations

  • Published online on: July 31, 2014     https://doi.org/10.3892/ol.2014.2401
  • Pages: 1849-1855
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Glioblastomas (GBMs) are the most common and aggressive malignant primary brain tumors found in humans. In high‑grade gliomas, vasculogenic mimicry (VM) is often detected. VM is the formation of de novo vascular networks by highly invasive tumor cells, instead of endothelial cells. An understanding of the mechanisms of VM formation will contribute to the targeted therapy of GBMs. In the present study, the efficacy of curcumin (CCM) on VM formation and its mechanisms were investigated. It was found that CCM inhibits the VM formation, proliferation, migration and invasion of human glioma U251 cells in a dose‑dependent manner. Furthermore, CCM downregulated the protein and mRNA expression of erythropoietin‑producing hepatocellular carcinoma‑A2, phosphoinositide 3‑kinase and matrix metalloproteinase‑2, indicating that CCM may function through these factors for the inhibition of VM formation. These data provide novel insights into the use of CCM to antagonize VM, and may contribute to the angiogenesis‑targeted therapy of malignant glioma.
View Figures
View References

Related Articles

Journal Cover

October 2014
Volume 8 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Liang Y, Huang M, Li J, Sun X, Jiang X, Li L and Ke Y: Curcumin inhibits vasculogenic mimicry through the downregulation of erythropoietin‑producing hepatocellular carcinoma‑A2, phosphoinositide 3‑kinase and matrix metalloproteinase‑2. Oncol Lett 8: 1849-1855, 2014
APA
Liang, Y., Huang, M., Li, J., Sun, X., Jiang, X., Li, L., & Ke, Y. (2014). Curcumin inhibits vasculogenic mimicry through the downregulation of erythropoietin‑producing hepatocellular carcinoma‑A2, phosphoinositide 3‑kinase and matrix metalloproteinase‑2. Oncology Letters, 8, 1849-1855. https://doi.org/10.3892/ol.2014.2401
MLA
Liang, Y., Huang, M., Li, J., Sun, X., Jiang, X., Li, L., Ke, Y."Curcumin inhibits vasculogenic mimicry through the downregulation of erythropoietin‑producing hepatocellular carcinoma‑A2, phosphoinositide 3‑kinase and matrix metalloproteinase‑2". Oncology Letters 8.4 (2014): 1849-1855.
Chicago
Liang, Y., Huang, M., Li, J., Sun, X., Jiang, X., Li, L., Ke, Y."Curcumin inhibits vasculogenic mimicry through the downregulation of erythropoietin‑producing hepatocellular carcinoma‑A2, phosphoinositide 3‑kinase and matrix metalloproteinase‑2". Oncology Letters 8, no. 4 (2014): 1849-1855. https://doi.org/10.3892/ol.2014.2401