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Article

Prognostic value of serum γ‑glutamyl transferase in unresectable hepatocellular carcinoma patients treated with transcatheter arterial chemoembolization combined with conformal radiotherapy

  • Authors:
    • Dong Chen
    • Renben Wang
    • Xiangjiao Meng
    • Hongjiang Yan
    • Shumei Jiang
    • Rui Feng
    • Kunli Zhu
    • Xiaoqing Xu
    • Xue Dou
    • Linzhi Jin
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Shandong Cancer Hospital, Jinan, Shandong 250117, P.R. China
  • Pages: 2298-2304
    |
    Published online on: August 19, 2014
       https://doi.org/10.3892/ol.2014.2456
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Abstract

The detection of γ‑glutamyl transferase (GGT) has previously been reported to be useful in the diagnosis in hepatocellular carcinoma (HCC). The aim of the present study was to investigate the baseline serum GGT levels in patients with intermediate HCC (Barcelona Clinic Liver Cancer stage B) following treatment with transcatheter arterial chemoembolization (TACE) combined with three‑dimensional conformal radiotherapy (3DCRT). A total of 154 intermediate HCC patients with Child‑Pugh grade A were retrospectively investigated. Receiver operating characteristic (ROC) analysis was used to determine the optimal threshold for the GGT serum levels, and univariate and multivariate analyses were used to establish the prognostic factors. The median overall survival (OS) time was 24.3 months. The optimal threshold for GGT was 85 U/L (sensitivity, 75.13%; specificity, 69.81%; and area under the ROC curve, 0.763). The one‑, three‑ and five‑year OS rates were 79.9, 49.7 and 17.2%, respectively, for patients with low GGT levels (≤85 U/l) and 52.3, 22.1 and 8.5%, respectively, for patients with high GGT levels (>85 U/l) (P=0.007). The results indicated that the serum GGT level was an independent prognostic factor (hazard ratio=2.32; P=0.007) for OS. Furthermore, in subgroups stratified according to serum α‑fetoprotein, gross tumor volume and radiation dose, serum GGT was also found to correlate with OS (P<0.05). Therefore, the baseline GGT level may be a significant prognostic factor for intermediate HCC patients with Child‑Pugh grade A following TACE combined with 3DCRT.
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Copy and paste a formatted citation
Spandidos Publications style
Chen D, Wang R, Meng X, Yan H, Jiang S, Feng R, Zhu K, Xu X, Dou X, Jin L, Jin L, et al: Prognostic value of serum γ‑glutamyl transferase in unresectable hepatocellular carcinoma patients treated with transcatheter arterial chemoembolization combined with conformal radiotherapy. Oncol Lett 8: 2298-2304, 2014.
APA
Chen, D., Wang, R., Meng, X., Yan, H., Jiang, S., Feng, R. ... Jin, L. (2014). Prognostic value of serum γ‑glutamyl transferase in unresectable hepatocellular carcinoma patients treated with transcatheter arterial chemoembolization combined with conformal radiotherapy. Oncology Letters, 8, 2298-2304. https://doi.org/10.3892/ol.2014.2456
MLA
Chen, D., Wang, R., Meng, X., Yan, H., Jiang, S., Feng, R., Zhu, K., Xu, X., Dou, X., Jin, L."Prognostic value of serum γ‑glutamyl transferase in unresectable hepatocellular carcinoma patients treated with transcatheter arterial chemoembolization combined with conformal radiotherapy". Oncology Letters 8.5 (2014): 2298-2304.
Chicago
Chen, D., Wang, R., Meng, X., Yan, H., Jiang, S., Feng, R., Zhu, K., Xu, X., Dou, X., Jin, L."Prognostic value of serum γ‑glutamyl transferase in unresectable hepatocellular carcinoma patients treated with transcatheter arterial chemoembolization combined with conformal radiotherapy". Oncology Letters 8, no. 5 (2014): 2298-2304. https://doi.org/10.3892/ol.2014.2456
Copy and paste a formatted citation
x
Spandidos Publications style
Chen D, Wang R, Meng X, Yan H, Jiang S, Feng R, Zhu K, Xu X, Dou X, Jin L, Jin L, et al: Prognostic value of serum γ‑glutamyl transferase in unresectable hepatocellular carcinoma patients treated with transcatheter arterial chemoembolization combined with conformal radiotherapy. Oncol Lett 8: 2298-2304, 2014.
APA
Chen, D., Wang, R., Meng, X., Yan, H., Jiang, S., Feng, R. ... Jin, L. (2014). Prognostic value of serum γ‑glutamyl transferase in unresectable hepatocellular carcinoma patients treated with transcatheter arterial chemoembolization combined with conformal radiotherapy. Oncology Letters, 8, 2298-2304. https://doi.org/10.3892/ol.2014.2456
MLA
Chen, D., Wang, R., Meng, X., Yan, H., Jiang, S., Feng, R., Zhu, K., Xu, X., Dou, X., Jin, L."Prognostic value of serum γ‑glutamyl transferase in unresectable hepatocellular carcinoma patients treated with transcatheter arterial chemoembolization combined with conformal radiotherapy". Oncology Letters 8.5 (2014): 2298-2304.
Chicago
Chen, D., Wang, R., Meng, X., Yan, H., Jiang, S., Feng, R., Zhu, K., Xu, X., Dou, X., Jin, L."Prognostic value of serum γ‑glutamyl transferase in unresectable hepatocellular carcinoma patients treated with transcatheter arterial chemoembolization combined with conformal radiotherapy". Oncology Letters 8, no. 5 (2014): 2298-2304. https://doi.org/10.3892/ol.2014.2456
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