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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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November-2014 Volume 8 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Case Report

Erythropoietin production in renal cell carcinoma and renal cysts in autosomal dominant polycystic kidney disease in a chronic dialysis patient with polycythemia: A case report

  • Authors:
    • Keiichi Ito
    • Takako Asano
    • Susumu Tominaga
    • Hidehiko  Yoshii
    • Harutake Sawazaki
    • Tomohiko Asano
  • View Affiliations / Copyright

    Affiliations: Department of Urology, National Defense Medical College, Tokorozawa, Saitama 359‑8513, Japan, Department of Pathology, National Defense Medical College, Tokorozawa, Saitama 359‑8513, Japan
  • Pages: 2032-2036
    |
    Published online on: August 21, 2014
       https://doi.org/10.3892/ol.2014.2469
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Abstract

In patients undergoing chronic hemodialysis (HD), erythropoietin (EPO) production from the kidney generally decreases and renal anemia develops. Patients without anemia, but with high serum EPO (sEPO) levels are rare among HD patients. The current study presents the case of a 67‑year‑old female HD patient with autosomal dominant polycystic kidney disease (ADPKD) and renal cell carcinoma (RCC), manifesting polycythemia with elevated sEPO levels. A radical nephrectomy was performed, which diminished the polycythemia, but the sEPO levels remained high. To determine the origin of the EPO production, immunohistochemistry was performed to detect EPO in the RCC and the renal cysts of the surgically resected kidney. In addition, the sEPO and EPO levels in a renal cyst were determined by enzyme immunoassay. EPO expression was demonstrated in RCC and cyst epithelial cells using immunohistochemistry, revealing extremely high EPO levels in the cyst fluid. Due to the remission of polycythemia following the nephrectomy, EPO production from the resected kidney appeared to have been the cause of the polycythemia. Positive EPO staining of the renal cysts in the resected polycystic kidney and sustained sEPO elevation following nephrectomy led to the hypothesis of EPO production in the renal cysts of the contralateral polycystic kidney. Although the postoperative EPO level was higher than the normal range, the hematocrit (Hct) level gradually decreased and recombinant human EPO was required again three months following the nephrectomy. Eight months after the nephrectomy, the Hct level was 30.2% with the use of rHuEPO. In conclusion, EPO production from RCC and renal cysts in ADPKD appeared to cause polycythemia in the HD patient.
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Copy and paste a formatted citation
Spandidos Publications style
Ito K, Asano T, Tominaga S, Yoshii H, Sawazaki H and Asano T: Erythropoietin production in renal cell carcinoma and renal cysts in autosomal dominant polycystic kidney disease in a chronic dialysis patient with polycythemia: A case report. Oncol Lett 8: 2032-2036, 2014.
APA
Ito, K., Asano, T., Tominaga, S., Yoshii, H., Sawazaki, H., & Asano, T. (2014). Erythropoietin production in renal cell carcinoma and renal cysts in autosomal dominant polycystic kidney disease in a chronic dialysis patient with polycythemia: A case report. Oncology Letters, 8, 2032-2036. https://doi.org/10.3892/ol.2014.2469
MLA
Ito, K., Asano, T., Tominaga, S., Yoshii, H., Sawazaki, H., Asano, T."Erythropoietin production in renal cell carcinoma and renal cysts in autosomal dominant polycystic kidney disease in a chronic dialysis patient with polycythemia: A case report". Oncology Letters 8.5 (2014): 2032-2036.
Chicago
Ito, K., Asano, T., Tominaga, S., Yoshii, H., Sawazaki, H., Asano, T."Erythropoietin production in renal cell carcinoma and renal cysts in autosomal dominant polycystic kidney disease in a chronic dialysis patient with polycythemia: A case report". Oncology Letters 8, no. 5 (2014): 2032-2036. https://doi.org/10.3892/ol.2014.2469
Copy and paste a formatted citation
x
Spandidos Publications style
Ito K, Asano T, Tominaga S, Yoshii H, Sawazaki H and Asano T: Erythropoietin production in renal cell carcinoma and renal cysts in autosomal dominant polycystic kidney disease in a chronic dialysis patient with polycythemia: A case report. Oncol Lett 8: 2032-2036, 2014.
APA
Ito, K., Asano, T., Tominaga, S., Yoshii, H., Sawazaki, H., & Asano, T. (2014). Erythropoietin production in renal cell carcinoma and renal cysts in autosomal dominant polycystic kidney disease in a chronic dialysis patient with polycythemia: A case report. Oncology Letters, 8, 2032-2036. https://doi.org/10.3892/ol.2014.2469
MLA
Ito, K., Asano, T., Tominaga, S., Yoshii, H., Sawazaki, H., Asano, T."Erythropoietin production in renal cell carcinoma and renal cysts in autosomal dominant polycystic kidney disease in a chronic dialysis patient with polycythemia: A case report". Oncology Letters 8.5 (2014): 2032-2036.
Chicago
Ito, K., Asano, T., Tominaga, S., Yoshii, H., Sawazaki, H., Asano, T."Erythropoietin production in renal cell carcinoma and renal cysts in autosomal dominant polycystic kidney disease in a chronic dialysis patient with polycythemia: A case report". Oncology Letters 8, no. 5 (2014): 2032-2036. https://doi.org/10.3892/ol.2014.2469
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