Electron microscopic analysis of an angiosarcoma of the thyroid from a non‑Alpine endemic goiter region: A case report and brief review of the literature

Altınay,Serdar; Özen,Aynur; Namal,Esat; Ertürküner,Pelin

doi:10.3892/ol.2014.2470

November-2014 Volume 8 Issue 5

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November-2014 Volume 8 Issue 5

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Case Report

Electron microscopic analysis of an angiosarcoma of the thyroid from a non‑Alpine endemic goiter region: A case report and brief review of the literature

Authors:
- Serdar Altınay
- Aynur Özen
- Esat Namal
- Pelin Ertürküner
View Affiliations / Copyright

Affiliations: Department of Pathology, Thyroid Unit, Bağcılar Training and Education Hospital, Istanbul 34203, Turkey, Department of Nuclear Medicine, Bağcılar Training and Education Hospital, Istanbul 34203, Turkey, Department of Oncology, Bağcılar Training and Education Hospital, Istanbul 34203, Turkey, Department of Histology and Embryology, Medical Faculty of Cerrahpaşa, Istanbul University, Istanbul 34098, Turkey
Pages: 2117-2121
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Published online on: August 21, 2014

https://doi.org/10.3892/ol.2014.2470
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Abstract

Angiomatoid tumors of the thyroid gland are rare endocrine neoplasms, which exhibit an aggressive behavior. Angiosarcomas of the thyroid are generally reported from the European Alpine region and have a histogenesis that has been under debate for a number of years. The current study presents a rare case of angiosarcoma of the thyroid in a 62‑year‑old Turkish female. The patient had a 10‑year history of goiter and was from the Black Sea region, an endemic goiter region of Turkey. The patient was not taking any medication at the time of admission and swelling had been observed on the right side of the neck throughout the previous few months. Thyroid function tests, which analyzed the levels of thyroid‑stimulating hormone, thyroxine and triiodothyronine, were within the normal limits, however, the histopathological findings were consistent with an angiosarcoma of the thyroid. The patient rejected the complementary surgery and chemotherapy options, and is currently disease‑free (as per the 15‑month follow-up). The current study describes a case of angiosarcoma that was characterized by Weibel‑Palade bodies, and light microscopy and immunohistochemical findings, as well as an endothelial origin, which was demonstrated via electron microscopy. To the best of our knowledge, this is the first reported case of angiosarcoma of the thyroid in a patient from Turkey to be validated by electron microscopy. Furthermore, this case is one of the few reported thyroid angiosarcoma cases in a non‑Alpine region.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Electron microscopic analysis of an angiosarcoma of the thyroid from a non‑Alpine endemic goiter region: A case report and brief review of the literature

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