Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
November-2014 Volume 8 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2014 Volume 8 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report

Clinical outcome of thymic lymphoepithelioma‑like carcinoma: Case report of a 14‑year‑old male

  • Authors:
    • Kuniko Sekihara
    • Yusuke Okuma
    • Hiroshi Kawamoto
    • Yukio Hosomi
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Oncology and Respiratory Medicine, Tokyo Metropolitan Cancer and Infectious diseases Center, Komagome Hospital, Tokyo 113‑8677, Japan, Department of Thoracic Oncology and Respiratory Medicine, Tokyo Metropolitan Cancer and Infectious diseases Center, Komagome Hospital, Tokyo 113‑8677, Japan, Department of Pediatrics, National Cancer Center Hospital, Tokyo 104‑0045, Japan
  • Pages: 2183-2186
    |
    Published online on: August 22, 2014
       https://doi.org/10.3892/ol.2014.2475
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Thymic carcinoma is a rare type of cancer, which arises from the thymic epithelium and accounts for ~1‑4% of anterior mediastinal tumors in the USA. It rarely occurs in children, and is rarer among adults. Thymic lymphoepithelioma‑like carcinoma (LELC) is an uncommon subtype of thymic carcinoma in children, however, it is one of the common histological subtypes of thymic carcinoma in adults. In the present study, a 14‑year‑old male patient presented to the Tokyo Metropolitan Cancer and Infectious diseases Center, Komagome Hospital (Tokoyo, Japan) with chest pain due to a large anterior mediastinal mass. The patient was histologically diagnosed with thymic LELC via a needle biopsy specimen, which was obtained from the primary site and indicated the Epstein‑Barr virus infection, whose markers are also associated with oncogenesis. Immunohistochemical analysis demonstrated positive staining for keratin (AE1/AE3), epithelial membrane antigen, and latent membrane protein‑1 and negative staining for cluster of differentiation 5. Thus, the patient was diagnosed with metastatic thymic LELC. First‑line chemotherapy comprising of a cisplatin‑ and adriamycin‑based chemotherapy regimen achieved a partial response, however, the patient succumbed within 10 months of the initial diagnosis due to rapid disease progression and refractory to subsequent cycles of chemotherapy. Thus, the current study, as well as previously reported cases, demonstrates that pediatric patients with thymic LELC continue to have a poor prognosis.
View Figures
View References

1 

Engels EA and Pfeiffer RM: Malignant thymoma in the United States: demographic patterns in incidence and associations with subsequent malignancies. Int J Cancer. 105:546–551. 2003.

2 

Rare Cancers Europe. http://www.rarecancerseurope.org/About-Rare-Cancers. Accessed August 12, 2014

3 

Rosai J: Histological typing of tumours of the thymus. World Health Organization International histological classification of tumours Berlin: Springer-Verlag; pp. 5–15. 1999

4 

Travis WD, Brambilla E, Müller-Hermelink HK and Harris CC: Tumours of the thymus. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. IARC Press; Lyon: pp. 145–247. 2004

5 

Wick MR, Scheithauer BW and Dines DE: Thymic neoplasia in two male siblings. Mayo Clin Proc. 57:653–656. 1982.

6 

Marino M and Müller-Hermelink HK: Thymoma and thymic carcinoma. Relation of thymoma epithelial cells to the cortical and medullary differentiation of thymus. Virchows Arch A Pathol Anat Histopathol. 407:119–149. 1985.

7 

Fujii T, Kawai T, Saito K, et al: EBER-1 expression in thymic carcinoma. Acta Pathol Jpn. 43:107–110. 1993.

8 

Ilhan I, Kutluk T, Göğüş S, Besim A and Büyükpamukçu M: Hypertrophic pulmonary osteoarthropathy in a child with thymic carcinoma: an unusual presentation in childhood. Med Pediatr Oncol. 23:140–143. 1994.

9 

Niehues T, Harms D, Jürgens H and Göbel U: Treatment of pediatric malignant thymoma: long-term remission in a 14-year-old boy with EBV-associated thymic carcinoma by aggressive, combined modality treatment. Med Pediatr Oncol. 26:419–424. 1996.

10 

Stéphan JL, Galambrun C, Boucheron S, et al: Epstein-Barr virus - positive undifferentiated thymic carcinoma in a 12-year-old white girl. J Pediatr Hematol Oncol. 22:162–166. 2000.

11 

Di Cataldo A, Villari L, Milone P, et al: Thymic carcinoma, systemic lupus erythematosus, and hypertrophic pulmonary osteoarthropathy in an 11-year-old boy: a novel association. Pediatr Hematol Oncol. 17:701–706. 2000.

12 

Yaris N, Nas Y, Cobanoglu U and Yavuz MN: Thymic carcinoma in children. Pediatr Blood Cancer. 47:224–227. 2006.

13 

Hsueh C, Kuo TT, Tsang NM, et al: Thymic lymphoepitheliomalike carcinoma in children: clinicopathologic features and molecular analysis. J Pediatr Hematol Oncol. 28:785–790. 2006.

14 

Tacyildiz N, Ugur H, Yavuz G, et al: The coexistence of thymic carcinoma and multiple granulomas in a Turkish child. Pediatr Hematol Oncol. 24:301–307. 2007.

15 

Kiliś-Pstrusińska K, Medyńska A, Zwolińska D and Dobaczewski G: Lymphoepithelioma-like thymic carcinoma in a 16-year-old boy with nephrotic syndrome - a case report. Pediatr Nephrol. 23:1001–1003. 2008.

16 

Ettinger DS, Riely GJ, Akerley W, et al: National Comprehensive Cancer Network: Thymomas and thymic carcinomas: Clinical practice guidelines in oncology. J Natl Compr Canc Netw. 11:562–576. 2013.

17 

Kunitoh H, Tamura T, Shibata T, et al: A phase-II trial of dose-dense chemotherapy in patients with disseminated thymoma: report of a Japan Clinical Oncology Group trial (JCOG 9605). Br J Cancer. 101:1549–1554. 2009.

18 

Okuma Y, Hosomi Y, Takagi Y, et al: Clinical outcomes with chemotherapy for advanced thymic carcinoma. Lung Cancer. 80:75–80. 2013.

19 

Masaoka A: Staging system of thymoma. J Thorac Oncol. 5(10 Suppl 4): S304–S312. 2010.

20 

Eisenhauer EA, Therasse P, Bogaerts J, et al: New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer. 45:228–247. 2009.

21 

Shimosato Y, Kameya T, Nagai K and Suemasu K: Squamous cell carcinoma of the thymus. An analysis of eight cases. Am J Surg Pathol. 1:109–121. 1977.

22 

Okuma Y, Shimokawa T, Takagi Y, et al: S-1 is an active anticancer agent for advanced thymic carcinoma. Lung Cancer. 70:357–363. 2010.

23 

Komatsu Y, Koizumi T, Tanabe T, et al: Salvage chemotherapy with carboplatin and paclitaxel for cisplatin-resistant thymic carcinoma - three cases. Anticancer Res. 26:4851–4855. 2006.

24 

Wu TC and Kuo TT: Study of Epstein-Barr virus early RNA 1 (EBER1) expression by in situ hybridization in thymic epithelial tumors of Chinese patients in Taiwan. Hum Pathol. 24:235–238. 1993.

25 

Chen FF, Yan JJ, Lai WW, Jin YT and Su IJ: Epstein-Barr virus-associated nonsmall cell lung carcinoma: undifferentiated “lymphoepithelioma-like” carcinoma as a distinct entity with better prognosis. Cancer. 82:2334–2342. 1998.

26 

Chalabreysse L, Etienne-Mastroianni B, Adeleine P, et al: Thymic carcinoma: a clinicopathological and immunohistological study of 19 cases. Histopathology. 44:367–374. 2004.

27 

Ettinger DS, Riely GJ, Akerley W, et al: Thymomas and thymic carcinomas: Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 11:562–576. 2013.

28 

Agatsuma T, Koizumi T, Kanda S, et al: Combination chemotherapy with doxorubicin, vincristine, cyclophosphamide, and platinum compounds for advanced thymic carcinoma. J Thorac Oncol. 6:2130–2134. 2011.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Sekihara K, Okuma Y, Kawamoto H and Hosomi Y: Clinical outcome of thymic lymphoepithelioma‑like carcinoma: Case report of a 14‑year‑old male. Oncol Lett 8: 2183-2186, 2014.
APA
Sekihara, K., Okuma, Y., Kawamoto, H., & Hosomi, Y. (2014). Clinical outcome of thymic lymphoepithelioma‑like carcinoma: Case report of a 14‑year‑old male. Oncology Letters, 8, 2183-2186. https://doi.org/10.3892/ol.2014.2475
MLA
Sekihara, K., Okuma, Y., Kawamoto, H., Hosomi, Y."Clinical outcome of thymic lymphoepithelioma‑like carcinoma: Case report of a 14‑year‑old male". Oncology Letters 8.5 (2014): 2183-2186.
Chicago
Sekihara, K., Okuma, Y., Kawamoto, H., Hosomi, Y."Clinical outcome of thymic lymphoepithelioma‑like carcinoma: Case report of a 14‑year‑old male". Oncology Letters 8, no. 5 (2014): 2183-2186. https://doi.org/10.3892/ol.2014.2475
Copy and paste a formatted citation
x
Spandidos Publications style
Sekihara K, Okuma Y, Kawamoto H and Hosomi Y: Clinical outcome of thymic lymphoepithelioma‑like carcinoma: Case report of a 14‑year‑old male. Oncol Lett 8: 2183-2186, 2014.
APA
Sekihara, K., Okuma, Y., Kawamoto, H., & Hosomi, Y. (2014). Clinical outcome of thymic lymphoepithelioma‑like carcinoma: Case report of a 14‑year‑old male. Oncology Letters, 8, 2183-2186. https://doi.org/10.3892/ol.2014.2475
MLA
Sekihara, K., Okuma, Y., Kawamoto, H., Hosomi, Y."Clinical outcome of thymic lymphoepithelioma‑like carcinoma: Case report of a 14‑year‑old male". Oncology Letters 8.5 (2014): 2183-2186.
Chicago
Sekihara, K., Okuma, Y., Kawamoto, H., Hosomi, Y."Clinical outcome of thymic lymphoepithelioma‑like carcinoma: Case report of a 14‑year‑old male". Oncology Letters 8, no. 5 (2014): 2183-2186. https://doi.org/10.3892/ol.2014.2475
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team