Pattern of malignant solid tumors and lymphomas in children in the east delta of Egypt: A five‑year study

Hesham,Mervat; Atfy,Mervat; Hassan,Tamer; Abdo,Mohamed; Morsy,Saed; El Malky,Mohamed; Latif,Dalia  Abdel

doi:10.3892/ol.2014.2501

November-2014 Volume 8 Issue 5

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November-2014 Volume 8 Issue 5

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Article

Pattern of malignant solid tumors and lymphomas in children in the east delta of Egypt: A five‑year study

Authors:
- Mervat Hesham
- Mervat Atfy
- Tamer Hassan
- Mohamed Abdo
- Saed Morsy
- Mohamed El Malky
- Dalia Abdel Latif
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Affiliations: Pediatrics Department, Zagazig University, Zagazig 44111, Egypt, Pediatrics Department, Zagazig University, Zagazig 44111, Egypt
Pages: 2328-2332
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Published online on: September 4, 2014

https://doi.org/10.3892/ol.2014.2501
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Abstract

Worldwide, the incidence and mortality rates of childhood cancers differ. The study of incidence patterns and survival rates in childhood malignancies is important in aiding in the planning of treatment centers and in obtaining further information with regard to the etiology. Few studies have investigated the survival in cases of childhood solid tumors in Egypt. The aim of the current study was to evaluate the patterns, frequency and outcome of solid tumors and lymphomas in children admitted to and followed up at the Pediatric Oncology Department of Zagazig University Hospital (Zagazig, Egypt) over a duration of 5 years (January 2004 to December 2008). A retrospective study was conducted, which included 155 children with solid tumors and lymphomas. The medical records were reviewed and the relevant data collected, in particular, those concerning demographic, clinical, histopathological, laboratory and imaging data as well as the treatment plans and outcomes. The mean age of patients was 5.6±3.04 years at diagnosis. The patients comprised 94 males and 61 females. Non‑Hodgkin lymphoma (NHL) was the most common tumor type, followed by neuroblastoma (31.0 and 29.0%, respectively). When patients were stratified in terms of age (<5, ≥5 but <10, and ≥10 years), the <5‑years‑of‑age group exhibited the greatest number of patients. Fever, pallor and pain were the most frequent initial clinical presentations among the patients and stage II was the most common stage (39.1%) followed by stage IV, III and I (35.0, 20.3 and 5.6% respectively). The overall 5‑year survival rate in the study group was 66.7%. The survival rate was significantly higher in patients with Wilm's tumor and Hodgkin lymphoma, followed by NHL (92.0, 88.0 and 72.0%, respectively; P<0.001), while the mortality rate was significantly higher in patients with neuroblastoma (P<0.001). In conclusion, NHL and neuroblastoma were the most common tumors; the survival rates were higher in patients with Wilm's tumor and Hodgkin lymphoma and lower in patients with neuroblastoma. A larger multicenter study is required to further investigate the conclusions drawn from this study.

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1	Young JL Jr, Ries LG, Silverberg E, Horm JW and Miller RW: Cancer incidence, survival and mortality for children younger than age 15 years. Cancer. 58(2 Suppl): 598–602. 1986.
2	Moore SW, Satgé D, Sasco AJ, Zimmermann A and Plaschkes J: The epidemiology of neonatal tumours. Report of an international working group. Pediatr Surg Int. 19:509–519. 2003.
3	Greenlee RT, Murray T, Bolden S and Wingo PA: Cancer statistics 2000. CA Cancer J Clin. 50:7–33. 2000.
4	Grosfeld JL: Risk-based management: current concepts of treating malignant solid tumors of childhood. J Am Coll Surg. 189:407–425. 1999.
5	Christie B: Doctors revise Declaration of Helsinki. BMJ. 321:9132000.
6	Agboola AO, Adekanmbi FA, Musa AA, et al: Pattern of childhood malignant tumors in a teaching hospital in south-western Nigeria. Med J Aust. 190:12–14. 2009.
7	Pession A, Dama E, Rondelli R, et al: Italian Association of Paediatric Haematology and Oncology: Survival of children with cancer in Italy, 1989–1998. A report from hospital based registry of the Italian Association of Pediatric Hematology and Oncology (AIEOP). Eur J Cancer. 44:1282–1289. 2008.
8	Memon F, Rathi SL and Memon MH: Pattern of solid paediatric malignant neoplasm at Lumhs, Jamshoro, Pakistan. J Ayub Med Coll Abbottabad. 19:55–57. 2007.
9	Akinde OR, Abdukareem FB, Daramola AO, Anunobi CC and Banjo AA: Morphological pattern of childhood solid tumors in Lagos University Teaching Hospital. Nig Q J Hosp Med. 19:169–174. 2009.
10	Ibrahim AS: Childhood cancer in Egypt: National cancer Institute, Cairo University and Gharbia population based registry, Egypt (2000–2002). Pediatr Hematol Oncol. 29:8–9. 2002.
11	Varan A, Büyükpamukçu M, Ersoy F, et al: Malignant solid tumors associated with congenital immunodeficiency disorders. Pediatr Hematol Oncol. 21:441–451. 2004.
12	Juárez-Ocaña S, González-Miranda G, Mejía-Aranguré JM, et al: Frequency of cancer in children residening in Mexico city and treated in hospital of Instituo of Mexicano del Segruro Social (1996–2001). BMC Cancer. 13:502004.
13	Valsecchi MG, Tognoni G, Bonilla M, et al: Monza’s International School of Paediatric Hematology-Oncology: Clinical epidemiology of childhood cancer in Central America and Caribbean countries. Ann Oncol. 15:680–685. 2004.
14	Vasudevan V, Cheung MC, Yang R, et al: Pediatric solid tumors and second malignancies: characteristics and survival outcomes. J Surg Res. 160:184–189. 2010.
15	Gao XN, Tang SQ and Lin J: Clinical features and prognosis of advanced neuroblastoma in children. Zhongguo Dang Dai Er Ke Za Zhi. 9:351–354. 2007.(In Chinese).
16	Ries LAG, Melbert D, Krapcho M, et al: SEER Cancer Statistics Review, 1975–2004. National Cancer Institute; Bethesda, MD: http://seer.cancer.gov/csr/1975_2004/. based on November 2006 SEER data submission, posted to the SEER website. 2007
17	Smith MA, Seibel NL, Altekruse SF, et al: Outcomes for children and adolescents with cancer: challenges for the twenty-first century. J Clin Oncol. 28:2625–2634. 2010.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Pattern of malignant solid tumors and lymphomas in children in the east delta of Egypt: A five‑year study

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