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Article

Involvement of the Akt signaling pathway in ER‑α36/GRP94‑mediated signaling in gastric cancer

  • Authors:
    • Zhengqi Fu
    • Hongyan Zhen
    • Feng Zou
    • Xuming Wang
    • Ying Chen
    • Lijiang Liu
  • View Affiliations / Copyright

    Affiliations: Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, Hubei 430056, P.R. China, Jiangda Pathology Institute, Jianghan University, Wuhan, Hubei 430056, P.R. China
  • Pages: 2077-2080
    |
    Published online on: September 9, 2014
       https://doi.org/10.3892/ol.2014.2514
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Abstract

Glucose‑regulated protein 94 (GRP94) has been implicated in the promotion of tumor proliferation and metastasis. Previous studies have found that GRP94 is involved in the malignant growth of gastric carcinoma cells through estrogen receptor‑α36 (ER‑α36)‑mediated estrogen signaling, but the underlying mechanism remains unclear. In the present study, we examined the expression levels of GRP94 and ER-α36 in tumor specimens from gastric cancer patients by immunohistochemistry, and found that both GRP94 and ER-α36 were highly expressed in the cyto­plasms of gastric carcinoma cells.Furthermore, treatment with 17β‑estradiol at a concentration of 10−12 M for 24 h increased the expression levels of GRP94 and ER‑α36, and the phosphorylation levels of Akt at the Ser473 site (Ser473‑Akt). In established SGC7901 gastric cancer cells with knockdown of ER‑α36 expression, the levels of GRP94 and Ser473‑Akt expression were significantly reduced. Thus, the Akt signaling pathway is a potentially important signaling pathway in ER‑α36‑GRP94‑mediated gastric carcinogenesis.
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Copy and paste a formatted citation
Spandidos Publications style
Fu Z, Zhen H, Zou F, Wang X, Chen Y and Liu L: Involvement of the Akt signaling pathway in ER‑α36/GRP94‑mediated signaling in gastric cancer. Oncol Lett 8: 2077-2080, 2014.
APA
Fu, Z., Zhen, H., Zou, F., Wang, X., Chen, Y., & Liu, L. (2014). Involvement of the Akt signaling pathway in ER‑α36/GRP94‑mediated signaling in gastric cancer. Oncology Letters, 8, 2077-2080. https://doi.org/10.3892/ol.2014.2514
MLA
Fu, Z., Zhen, H., Zou, F., Wang, X., Chen, Y., Liu, L."Involvement of the Akt signaling pathway in ER‑α36/GRP94‑mediated signaling in gastric cancer". Oncology Letters 8.5 (2014): 2077-2080.
Chicago
Fu, Z., Zhen, H., Zou, F., Wang, X., Chen, Y., Liu, L."Involvement of the Akt signaling pathway in ER‑α36/GRP94‑mediated signaling in gastric cancer". Oncology Letters 8, no. 5 (2014): 2077-2080. https://doi.org/10.3892/ol.2014.2514
Copy and paste a formatted citation
x
Spandidos Publications style
Fu Z, Zhen H, Zou F, Wang X, Chen Y and Liu L: Involvement of the Akt signaling pathway in ER‑α36/GRP94‑mediated signaling in gastric cancer. Oncol Lett 8: 2077-2080, 2014.
APA
Fu, Z., Zhen, H., Zou, F., Wang, X., Chen, Y., & Liu, L. (2014). Involvement of the Akt signaling pathway in ER‑α36/GRP94‑mediated signaling in gastric cancer. Oncology Letters, 8, 2077-2080. https://doi.org/10.3892/ol.2014.2514
MLA
Fu, Z., Zhen, H., Zou, F., Wang, X., Chen, Y., Liu, L."Involvement of the Akt signaling pathway in ER‑α36/GRP94‑mediated signaling in gastric cancer". Oncology Letters 8.5 (2014): 2077-2080.
Chicago
Fu, Z., Zhen, H., Zou, F., Wang, X., Chen, Y., Liu, L."Involvement of the Akt signaling pathway in ER‑α36/GRP94‑mediated signaling in gastric cancer". Oncology Letters 8, no. 5 (2014): 2077-2080. https://doi.org/10.3892/ol.2014.2514
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