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Salvage therapy with mitoxantrone, etoposide, bleomycin and dexamethasone for refractory or relapsed aggressive non-Hodgkin's lymphoma patients with a poor performance status or comorbidity

  • Authors:
    • Xuede Lin
    • Xi Shi
    • Wucha Zeng
    • Min Zheng
    • Liming Huang
  • View Affiliations / Copyright

    Affiliations: Department of Chemotherapy, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, P.R. China
  • Pages: 2012-2016
    |
    Published online on: September 9, 2014
       https://doi.org/10.3892/ol.2014.2517
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Abstract

The treatment of refractory or relapsed aggressive non-Hodgkin's lymphoma (NHL) in patients in a state of poor health is difficult due to their ineligibility to receive intensive salvage chemotherapy. In the present study, 16 refractory or relapsed aggressive NHL patients with a poor performance status or comorbidities were treated with mitoxantrone, etoposide, bleomycin and dexamethasone (MEBD) therapy. The treatment consisted of 10 mg/m2 intravenous (IV) mitoxantrone on day 1, 75 mg/m2 IV etoposide on days 1-3, 20 mg IV dexamethasone on days 1-4 and 15 mg intramuscular bleomycin on days 1, 4, 8 and 12, every 21 days. The efficacy and toxicity of the regimen were evaluated. The overall response rate was 68.8%, with a complete response rate of 18.8% and a partial response rate of 50.0%. The efficacy of the treatment for B‑cell lymphoma was greater than that for T‑cell lymphoma. The median progression-free survival time for the patients was 16.7 months and the median overall survival time was 22.4 months. The one‑year overall survival rate was 62.5% and the two‑year overall survival rate was 43.8%. The most common toxicity symptom was myelosuppression. In conclusion, refractory or relapsed aggressive NHL patients with a poor performance status or comorbidity are eligible for chemotherapy. MEBD therapy is an effective and feasible salvage regimen for NHL patients in a state of poor health.
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Copy and paste a formatted citation
Spandidos Publications style
Lin X, Shi X, Zeng W, Zheng M and Huang L: Salvage therapy with mitoxantrone, etoposide, bleomycin and dexamethasone for refractory or relapsed aggressive non-Hodgkin's lymphoma patients with a poor performance status or comorbidity. Oncol Lett 8: 2012-2016, 2014.
APA
Lin, X., Shi, X., Zeng, W., Zheng, M., & Huang, L. (2014). Salvage therapy with mitoxantrone, etoposide, bleomycin and dexamethasone for refractory or relapsed aggressive non-Hodgkin's lymphoma patients with a poor performance status or comorbidity. Oncology Letters, 8, 2012-2016. https://doi.org/10.3892/ol.2014.2517
MLA
Lin, X., Shi, X., Zeng, W., Zheng, M., Huang, L."Salvage therapy with mitoxantrone, etoposide, bleomycin and dexamethasone for refractory or relapsed aggressive non-Hodgkin's lymphoma patients with a poor performance status or comorbidity". Oncology Letters 8.5 (2014): 2012-2016.
Chicago
Lin, X., Shi, X., Zeng, W., Zheng, M., Huang, L."Salvage therapy with mitoxantrone, etoposide, bleomycin and dexamethasone for refractory or relapsed aggressive non-Hodgkin's lymphoma patients with a poor performance status or comorbidity". Oncology Letters 8, no. 5 (2014): 2012-2016. https://doi.org/10.3892/ol.2014.2517
Copy and paste a formatted citation
x
Spandidos Publications style
Lin X, Shi X, Zeng W, Zheng M and Huang L: Salvage therapy with mitoxantrone, etoposide, bleomycin and dexamethasone for refractory or relapsed aggressive non-Hodgkin's lymphoma patients with a poor performance status or comorbidity. Oncol Lett 8: 2012-2016, 2014.
APA
Lin, X., Shi, X., Zeng, W., Zheng, M., & Huang, L. (2014). Salvage therapy with mitoxantrone, etoposide, bleomycin and dexamethasone for refractory or relapsed aggressive non-Hodgkin's lymphoma patients with a poor performance status or comorbidity. Oncology Letters, 8, 2012-2016. https://doi.org/10.3892/ol.2014.2517
MLA
Lin, X., Shi, X., Zeng, W., Zheng, M., Huang, L."Salvage therapy with mitoxantrone, etoposide, bleomycin and dexamethasone for refractory or relapsed aggressive non-Hodgkin's lymphoma patients with a poor performance status or comorbidity". Oncology Letters 8.5 (2014): 2012-2016.
Chicago
Lin, X., Shi, X., Zeng, W., Zheng, M., Huang, L."Salvage therapy with mitoxantrone, etoposide, bleomycin and dexamethasone for refractory or relapsed aggressive non-Hodgkin's lymphoma patients with a poor performance status or comorbidity". Oncology Letters 8, no. 5 (2014): 2012-2016. https://doi.org/10.3892/ol.2014.2517
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