Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
November-2014 Volume 8 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2014 Volume 8 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report

Late relapse of non‑seminomatous testicular cancer during treatment of multiple sclerosis with interferon β‑1a: A case report

  • Authors:
    • Isabel Blancas
    • Nuria Cárdenas
    • Mayte Delgado
    • Jose Miguel Jurado
    • Marta Legeren
    • Ana Villaescusa
    • Fernando Galvez
    • Marisol Yelamos
  • View Affiliations / Copyright

    Affiliations: Oncology Unit, Hospital Clinico San Cecilio, Granada 18012, Spain
  • Pages: 2179-2182
    |
    Published online on: September 10, 2014
       https://doi.org/10.3892/ol.2014.2519
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Germ cell tumors (GCTs) comprise 95% of malignant tumors arising in the testes. The present study reports a patient diagnosed with non‑seminomatous testicular cancer, stage IB, with a good risk prediction according to the International Germ Cell Cancer Collaborative Group classification. The patient received chemotherapy with bleomycin, etoposide and cisplatin, and achieved complete remission. Eleven years later, while receiving treatment with interferon β‑1a for multiple sclerosis, the patient developed a relapse of the original cancer in the lungs and lymph nodes. The majority of GCTs relapse within the first two years of treatment, while 2‑4% of patients can present with late relapses. There is no clear established association between multiple sclerosis and testicular cancer; we present the hypothesis that the inmunosupressor treatment that was administered for the multiple sclerosis promoted the cancer relapse.
View Figures
View References

1 

Motzer RJ, Agarwal N, Beard C, et al: NCCN clinical practice guidelines in oncology: testicular cancer. J Natl Compr Canc Netw. 10:672–693. 2009.

2 

Lebrun C, Debouverie M, Vermersch P, et al: Cancer risk and impact of disease-modifying treatments in patients with multiple sclerosis. Mult Scler. 14:399–405. 2008.

3 

Habek M, Brinar VV and Hajnsek S: The association of multiple sclerosis and Hodgkin’s disease: the role of Epstein-Barr virus infection. Mult Scler. 14:284–287. 2008.

4 

Ehrlich Y and Baniel J: Late relapse of testis cancer. Urol Clin North Am. 34:253–258. 2007.

5 

International Germ Cell Cancer Collaborative Group (IGCCCG). a prognostic factor-based staging system for metastatic germ cell cancers. J Clin Oncol. 15:594–603. 1997.

6 

Frohman EM, Racke MK and Raine CS: Multiple sclerosis - the plaque and its pahogenesis. N Engl J Med. 354:942–955. 2006.

7 

Levin MC, Lee S, Gardner LA, et al: Autoantibodies to non-myelin antigens as cotributors to the pathogenesis of multiple sclerosis. J Clin Cell Immunol. 2013:42013.

8 

Bellavista E, Santoro A, Galimberti D, et al: Current understanding on the role of standard and immunoproteasomes in inflammatory/immunological pathways of multiple sclerosis. Autoimmune Dis. 2014:7397052014.

9 

CAMMS223 Trial Investigators. Coles AJ, Compston DA, et al: Alemtuzumab vs. Interferon beta-1a in early multiple sclerosis. N Engl J Med. 359:1786–1801. 2008.

10 

Mullen JT, Vartanian TK and Atkins MB: Melanoma complicating treatment with natalizumab for multiple sclerosis. N Engl J Med. 358:647–648. 2008.

11 

Saxman S, Finch D, Gonin R, et al: Long-term follow-up of a phase III study of three versus four cycles of bleomycin, etoposide, and cisplatin in favorable-prognosis germ-cell tumores: the Indiana University Experience. J Clin Oncol. 16:702–706. 1998.

12 

Baniel J, Foster R, Gonin R, et al: Late relapse of testicular cancer. J Clin Oncol. 13:1170–1176. 1995.

13 

Oldenburg J, Martin JM and Fosså S: Late relapses of germ cell malingnacies: incidence, management, and prognosis. J Clin Oncol. 24:5503–5511. 2006.

14 

Sonpavde G, Huston TE and Roth BJ: Management of recurrent testicular germ cell tumors. Oncologist. 12:51–61. 2007.

15 

Feldman D, Bosl G, Sheinfeld J and Motzer RJ: Medical treatment of advanced testicular cancer. JAMA. 299:672–684. 2008.

16 

Ehrlich Y, Rosenbaum E and Baniel J: Late relapse of testis cancer. Curr Urol Rep. 14:518–524. 2013.

17 

Leibovitch I, Baniel J, Rowland RG, et al: Malignant testicular neoplasms in inmunosuppressed patients. J Urol. 155:1938–1942. 1996.

18 

Farmakis D, Pectasides M and Pectasides D: Recent advances in conventional-dose salvage chemotherapy in patients with cisplatin-resistant or refractory testicular germ cell tumors. Eur Urol. 48:400–407. 2005.

19 

Germá-Lluch JR, García del Muro X, Tabernero JM, et al: BOMP/EPI intesive alternating chemotherapy for IGCCC poor-prognosis germ-cell tumors: the Spanish Germ-Cell Cancer Group experience (GG). Ann Oncol. 10:289–293. 1999.

20 

De Giorgi U, Rosti G, Aieta M, et al: Phase II study of oxaliplatin and gemcitabine salvage chemotherapy in patients with cisplatin-refractory nonseminomatous germ cell tumor. Eur Urol. 50:1032–1039. 2006.

21 

Schmoll HJ, Kollmannsberger C, Metzner B, et al: Long-term results of first-line sequential high-dose etoposide, ifosfamide, and cisplatin chemotherapy plus autologous stem cell support for patients with advanced metastatic germ cell cancer: an extended phase I/II study of the German Testicular Cancer Study Group. J Clin Oncol. 21:4083–4091. 2003.

22 

Ayash LJ, Clarke M, Silver SM, et al: Double dose-intensive chemotherapy with autologus stem cell support for relapsed and refractory testicular cancer: the University of Michigan experience and literature review. Bone Marrow Transplant. 27:939–947. 2001.

23 

Miki T, Mizutani Y, Akaza H, et al: Long-term results of first-line sequential high-dose carboplatin, etoposide and ifosfamide chemotherapy with peripheral blood stem cell support for patients with advanced testicular germ cell tumor. Int J Urol. 14:54–59. 2007.

24 

Geldart TR, Gale J, Mckendrick J, et al: Late relapse of metastatic testicular nonseminomatous germ cell cancer: surgery is needed for cure. BJU Int. 98:353–358. 2006.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Blancas I, Cárdenas N, Delgado M, Jurado JM, Legeren M, Villaescusa A, Galvez F and Yelamos M: Late relapse of non‑seminomatous testicular cancer during treatment of multiple sclerosis with interferon β‑1a: A case report. Oncol Lett 8: 2179-2182, 2014.
APA
Blancas, I., Cárdenas, N., Delgado, M., Jurado, J.M., Legeren, M., Villaescusa, A. ... Yelamos, M. (2014). Late relapse of non‑seminomatous testicular cancer during treatment of multiple sclerosis with interferon β‑1a: A case report. Oncology Letters, 8, 2179-2182. https://doi.org/10.3892/ol.2014.2519
MLA
Blancas, I., Cárdenas, N., Delgado, M., Jurado, J. M., Legeren, M., Villaescusa, A., Galvez, F., Yelamos, M."Late relapse of non‑seminomatous testicular cancer during treatment of multiple sclerosis with interferon β‑1a: A case report". Oncology Letters 8.5 (2014): 2179-2182.
Chicago
Blancas, I., Cárdenas, N., Delgado, M., Jurado, J. M., Legeren, M., Villaescusa, A., Galvez, F., Yelamos, M."Late relapse of non‑seminomatous testicular cancer during treatment of multiple sclerosis with interferon β‑1a: A case report". Oncology Letters 8, no. 5 (2014): 2179-2182. https://doi.org/10.3892/ol.2014.2519
Copy and paste a formatted citation
x
Spandidos Publications style
Blancas I, Cárdenas N, Delgado M, Jurado JM, Legeren M, Villaescusa A, Galvez F and Yelamos M: Late relapse of non‑seminomatous testicular cancer during treatment of multiple sclerosis with interferon β‑1a: A case report. Oncol Lett 8: 2179-2182, 2014.
APA
Blancas, I., Cárdenas, N., Delgado, M., Jurado, J.M., Legeren, M., Villaescusa, A. ... Yelamos, M. (2014). Late relapse of non‑seminomatous testicular cancer during treatment of multiple sclerosis with interferon β‑1a: A case report. Oncology Letters, 8, 2179-2182. https://doi.org/10.3892/ol.2014.2519
MLA
Blancas, I., Cárdenas, N., Delgado, M., Jurado, J. M., Legeren, M., Villaescusa, A., Galvez, F., Yelamos, M."Late relapse of non‑seminomatous testicular cancer during treatment of multiple sclerosis with interferon β‑1a: A case report". Oncology Letters 8.5 (2014): 2179-2182.
Chicago
Blancas, I., Cárdenas, N., Delgado, M., Jurado, J. M., Legeren, M., Villaescusa, A., Galvez, F., Yelamos, M."Late relapse of non‑seminomatous testicular cancer during treatment of multiple sclerosis with interferon β‑1a: A case report". Oncology Letters 8, no. 5 (2014): 2179-2182. https://doi.org/10.3892/ol.2014.2519
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team