Acute myelocytic leukemia in a patient with hemophagocytic lymphohistiocytosis: A case report

Zhao,Defeng; Qian,Liren; Shen,Jianliang

doi:10.3892/ol.2014.2527

December-2014 Volume 8 Issue 6

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December-2014 Volume 8 Issue 6

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Case Report

Acute myelocytic leukemia in a patient with hemophagocytic lymphohistiocytosis: A case report

Authors:
- Defeng Zhao
- Liren Qian
- Jianliang Shen
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Affiliations: Department of Hematology, Navy General Hospital, Beijing 100048, P.R. China
Pages: 2634-2636
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Published online on: September 12, 2014

https://doi.org/10.3892/ol.2014.2527
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Abstract

Hemophagocytic lymphohistiocytosis (HLH), also known as hemophagocytic syndrome, is an aggressive hyperinflammatory condition characterized by prolonged fever, cytopenias and hepatosplenomegaly, as well as hemophagocytosis by activated, morphologically benign macrophages. HLH may be characterized into two forms, familial and secondary HLH. Familial HLH usually manifests in children with genetic abnormalities associated with the cytotoxic function of NK and T cells, whereas secondary HLH usually occurs in older patients in combination with an associated condition, such as infection or malignancy, without an identifiable genetic abnormality. Malignancy‑associated hemophagocytic lymphohistiocytosis is mostly accompanied by lymphoid neoplasms. The present study reports a rare case of this syndrome in combination with acute myeloblastic leukemia (AML‑M2), in a patient with clonal karyotypic abnormalities. The patient was successfully treated with chemotherapy comprising daunorubicin (40 mg/m2 i.v., days 1‑3) and cytosine arabinoside (100 mg/m2, 1‑h i.v. infusion, days 1‑7). All clinical symptoms disappeared following chemotherapy.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Acute myelocytic leukemia in a patient with hemophagocytic lymphohistiocytosis: A case report

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Abstract

Figure 1

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