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Article

Smac/DIABLO expression in human gastrointestinal carcinoma: Association with clinicopathological parameters and survivin expression

  • Authors:
    • Michiko Shintani
    • Akiko Sangawa
    • Naoki Yamao
    • Shingo Kamoshida
  • View Affiliations / Copyright

    Affiliations: Laboratory of Pathology, Division of Medical Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Hyogo 654‑0142, Japan, Department of Clinical Laboratory, Kuma Hospital, Kobe, Hyogo 650‑0011, Japan
  • Pages: 2581-2586
    |
    Published online on: October 9, 2014
       https://doi.org/10.3892/ol.2014.2598
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Abstract

Lack of apoptosis is a key factor in carcinogenesis and tumor progression. Survivin is a member of the inhibitor of apoptosis protein (IAP) family. Second mitochondria‑derived activator of caspases/direct inhibitor of apoptosis‑binding protein with low pI (Smac/DIABLO) is an antagonist of IAPs. Recently, Smac/DIABLO was identified as a potent therapeutic target. However, the clinical significance of Smac/DIABLO in gastrointestinal carcinomas remains unclear. In the present study, Smac/DIABLO expression was analyzed by immunohistochemistry in 72 gastric adenocarcinomas and 78 colorectal adenocarcinomas. The expression of Smac/DIABLO was significantly higher in colorectal carcinoma than in gastric carcinoma. Additionally, a correlation was found between the expression of Smac/DIABLO and nuclear survivin in well‑ to moderately‑differentiated colorectal adenocarcinomas (r=0.245; P<0.01). Based on these results, it was hypothesized that gastric and colorectal carcinomas differ in the level of Smac/DIABLO expression. Our previous studies revealed that the expression of cleaved caspase‑9 was significantly lower in colorectal carcinoma than in gastric carcinoma (P<0.0001). Conversely, the expression levels of microtubule‑associated protein 1 light chain 3 (LC3), an autophagy marker, and survivin were significantly higher in colon cancer than in gastric cancer (P<0.0001 and P<0.01, respectively). Taken together, these results indicate that not only LC3 and survivin expression, but also Smac/DIABLO expression, are significantly higher in colorectal carcinoma than in gastric carcinoma. We hypothesize that the analysis of Smac/DIABLO, survivin and LC3 expression in colorectal carcinoma is likely to aid cancer therapy due to the involvement of these markers in apoptosis and/or autophagy.
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Copy and paste a formatted citation
Spandidos Publications style
Shintani M, Sangawa A, Yamao N and Kamoshida S: Smac/DIABLO expression in human gastrointestinal carcinoma: Association with clinicopathological parameters and survivin expression. Oncol Lett 8: 2581-2586, 2014.
APA
Shintani, M., Sangawa, A., Yamao, N., & Kamoshida, S. (2014). Smac/DIABLO expression in human gastrointestinal carcinoma: Association with clinicopathological parameters and survivin expression. Oncology Letters, 8, 2581-2586. https://doi.org/10.3892/ol.2014.2598
MLA
Shintani, M., Sangawa, A., Yamao, N., Kamoshida, S."Smac/DIABLO expression in human gastrointestinal carcinoma: Association with clinicopathological parameters and survivin expression". Oncology Letters 8.6 (2014): 2581-2586.
Chicago
Shintani, M., Sangawa, A., Yamao, N., Kamoshida, S."Smac/DIABLO expression in human gastrointestinal carcinoma: Association with clinicopathological parameters and survivin expression". Oncology Letters 8, no. 6 (2014): 2581-2586. https://doi.org/10.3892/ol.2014.2598
Copy and paste a formatted citation
x
Spandidos Publications style
Shintani M, Sangawa A, Yamao N and Kamoshida S: Smac/DIABLO expression in human gastrointestinal carcinoma: Association with clinicopathological parameters and survivin expression. Oncol Lett 8: 2581-2586, 2014.
APA
Shintani, M., Sangawa, A., Yamao, N., & Kamoshida, S. (2014). Smac/DIABLO expression in human gastrointestinal carcinoma: Association with clinicopathological parameters and survivin expression. Oncology Letters, 8, 2581-2586. https://doi.org/10.3892/ol.2014.2598
MLA
Shintani, M., Sangawa, A., Yamao, N., Kamoshida, S."Smac/DIABLO expression in human gastrointestinal carcinoma: Association with clinicopathological parameters and survivin expression". Oncology Letters 8.6 (2014): 2581-2586.
Chicago
Shintani, M., Sangawa, A., Yamao, N., Kamoshida, S."Smac/DIABLO expression in human gastrointestinal carcinoma: Association with clinicopathological parameters and survivin expression". Oncology Letters 8, no. 6 (2014): 2581-2586. https://doi.org/10.3892/ol.2014.2598
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