CT‑guided 125I brachytherapy on pulmonary metastases after resection of colorectal cancer: A report of six cases

Shi,Shuyuan; Yang,Jingkui; Sun,Daqiang

doi:10.3892/ol.2014.2649

January-2015 Volume 9 Issue 1

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January-2015 Volume 9 Issue 1

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Article

CT‑guided 125I brachytherapy on pulmonary metastases after resection of colorectal cancer: A report of six cases

Authors:
- Shuyuan Shi
- Jingkui Yang
- Daqiang Sun
View Affiliations / Copyright

Affiliations: Department of Thoracic Surgery, Second Hospital of Tianjin Medical University, Tianjin 300211, P.R. China, Department of Thoracic Surgery, Tianjin Chest Hospital, Tianjin 300051, P.R. China
Pages: 375-380
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Published online on: October 30, 2014

https://doi.org/10.3892/ol.2014.2649
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Abstract

Colorectal cancer (CRC) is one of the most common malignancies in the world and distant metastasis is the main cause of cancer‑related mortality. Percutaneous computed tomography (CT) guided radioactive 125I seed implantation (CTRISI) is a minimally invasive technique used to treat pulmonary metastases in CRC patients. In the present study, following colorectal cancer resection, six patients with pulmonary metastases were treated with computed tomography (CT)‑guided percutaneous implantation of radioactive 125I seeds. At six months following seed implantation, CT examination was performed and compared with the images captured prior to the treatment. Of the total 13 lesions, four had disappeared, eight were reduced by >50% and one was enlarged, indicating that the local control rate was 92.3% (12/13). Overall, two patients developed intraoperative pneumothorax and one experienced hemoptysis subsequent to the procedure. Following a median follow‑up period of 31 months, no local recurrence was observed in 12 of the metastatic lesions. The mean survival time was 32.7 months and the median survival time was 31 months.

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1	Ferlay J, Soerjomataram I, Dikshit R, et al: Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. Sep 13–2014.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI
2	Talton BM, Constable WC and Kersh CR: Curative radiotherapy in non-small cell carcinoma of the lung. Int J Radiat Oncol Biol Phys. 19:15–21. 1990. View Article : Google Scholar : PubMed/NCBI
3	Rama N, Monteiro A, Bernardo JE, Eugénio L and Antunes MJ: Lung metastases from colorectal cancer: surgical resection and prognostic factors. Eur J Cardiothoracic Surg. 35:444–449. 2009. View Article : Google Scholar
4	Talton BM, Constable WC and Kersh CR: Curative radiotherapy in non-small cell carcinoma of the lung. Int J Radiat Oncol Biol Phys. 19:15–21. 1990. View Article : Google Scholar : PubMed/NCBI
5	Belderbos JS, Heemsbergen WD, De Jaeger K, Baas P and Lebesque JV: Final results of a Phase I/II dose escalation trial in non-small-cell lung cancer using three-dimensional conformal radiotherapy. Int J Radiat Oncol Biol Phys. 66:126–134. 2006. View Article : Google Scholar : PubMed/NCBI
6	Cha CM, Potters L, Ashley R, et al: Isotope selection for patients undergoing prostate brachytherapy. Int J Radiat Oncol Biol Phys. 45:391–395. 1999. View Article : Google Scholar : PubMed/NCBI
7	Martínez-Monge R, Pagola M, Vivas I and López-Picazo JM: CT-guided permanent brachytherapy for patients with medically inoperable early-stage non-small cell lung cancer (NSCLC). Lung Cancer. 61:209–213. 2008. View Article : Google Scholar : PubMed/NCBI
8	Zhang FJ, Li CX, Wu PH, et al: CT guided radioactive ¹²⁵I seed implantation in treating localized advanced pulmonary carcinoma. Zhonghua Yi Xue Za Zhi. 87:3272–3275. 2007.(In Chinese).
9	Martínez-Monge R, Garrán C, Vivas I and López-Picazo JM: Percutaneous CT-guided 103Pd implantation for the medically inoperable patient with T1N0M0 non-small cell lung cancer: a case report. Brachytherapy. 3:179–181. 2004. View Article : Google Scholar : PubMed/NCBI
10	Bradley J, Graham MV, Winter K, et al: Toxicity and outcome results of RTOG 9311: a phase I-II dose-escalation study using three-dimensional conformal radiotherapy in patients with inoperable non-small-cell lung carcinoma. Int J Radiat Oncol Biol Phys. 61:318–328. 2005. View Article : Google Scholar : PubMed/NCBI
11	Timmerman R, McGarry R, Yiannoutsos C, et al: Excessive toxicity when treating central tumors in a phase II study of stereotactic body radiation therapy for medically inoperable early-stage lung cancer. J Clin Oncol. 24:4833–4839. 2006. View Article : Google Scholar : PubMed/NCBI
12	Baumann P, Nyman J, Hoyer M, et al: Outcome in a prospective phase II trial of medically inoperable stage I non-small cell lung cancer patients treated with stereotactic body radiotherapy. J Clin Oncol. 27:3290–3296. 2009. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

CT‑guided 125I brachytherapy on pulmonary metastases after resection of colorectal cancer: A report of six cases

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