Characteristic waffle-like appearance of gastric linitis plastica: A case report

Maeda,Emiko; Oryu,Makoto; Tani,Joji; Miyoshi,Hisaaki; Morishita,Asahiro; Yoneyama,Hirohito; Kobara,Hideki; Mori,Hirohito; Masaki,Tsutomu

doi:10.3892/ol.2014.2688

January-2015 Volume 9 Issue 1

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January-2015 Volume 9 Issue 1

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Case Report

Characteristic waffle-like appearance of gastric linitis plastica: A case report

Authors:
- Emiko Maeda
- Makoto Oryu
- Joji Tani
- Hisaaki Miyoshi
- Asahiro Morishita
- Hirohito Yoneyama
- Hideki Kobara
- Hirohito Mori
- Tsutomu Masaki
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Affiliations: Department of Gastroenterology and Neurology, Kagawa University Faculty of Medicine, Kagawa 761‑0793, Japan
Pages: 262-264
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Published online on: November 7, 2014

https://doi.org/10.3892/ol.2014.2688
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Abstract

Linitis plastica is a gastric cancer of diffuse histotype that presents in the fundic gland area, and is characterized by thickening of the stomach wall and deformation of the stomach, resulting in a leather bottle‑like appearance. A 66‑year‑old female was admitted to Kagawa University Hospital (Kagawa, Japan) with epigastric pain. X‑ray examination revealed reduced gastric distension and deformation of the stomach, which exhibited a leather bottle‑like appearance. Endoscopy indicated a depressed lesion in the gastric antrum, and abnormal folds, which crossed to form a waffle‑like appearance in the upper gastric body. Analysis of biopsy specimens from the depressed lesion revealed a poorly differentiated adenocarcinoma. Morphological changes in the gastric folds indicated that the tumor had invaded the upper gastric body, therefore, a total gastrectomy was performed. Subsequent pathological findings demonstrated that the tumor had spread from the primary lesion to the upper gastric body. Therefore, the present report recommends that the diagnosis of the spread of linitis plastica‑type gastric cancer should include assessments of the primary lesion, as well as evaluation of morphological changes in the gastric folds.

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1	Lauren P: The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand. 64:31–49. 1965.PubMed/NCBI
2	Pedrazzani C, Marrelli D, Pacelli F, et al: Gastric linitis plastica: which role for surgical resection? Gastric Cancer. 15:56–60. 2012. View Article : Google Scholar
3	Japanese Gastric Cancer Association. Japanese classification of gastric carcinoma: 3rd English edition. Gastric Cancer. 14:101–112. 2011. View Article : Google Scholar : PubMed/NCBI
4	Whitehead R, Johansen A and Rubio CA: Other tumors of the stomach. Gastrointestinal and Oesophageal Pathology. Whitehead R: 2nd edition. Churchill Livingstone; New York, NY: pp. 823–836. 1995
5	Otsuji E, Kuriu Y, Okamoto K, et al: Outcome of surgical treatment for patients with scirrhous carcinoma of the stomach. Am J Surg. 188:327–332. 2004. View Article : Google Scholar : PubMed/NCBI
6	Kodera Y, Yamamura Y, Ito S, et al: Is Borrmann type IV gastric carcinoma a surgical disease? An old problem revisited with reference to the result of peritoneal washing cytology. J Surg Oncol. 78:175–182. 2001. View Article : Google Scholar : PubMed/NCBI
7	Qizilbash AH, Castelli M, Kowalski MA and Churly A: Endoscopic brush cytology and biopsy in the diagnosis of cancer of the upper gastrointestinal tract. Acta Cytol. 24:313–318. 1980.PubMed/NCBI
8	Llanos O, Guzmán S and Duarte I: Accuracy of the first endoscopic procedure in the differential diagnosis of gastric lesions. Ann Surg. 195:224–226. 1982. View Article : Google Scholar : PubMed/NCBI
9	Winawer SJ, Posner G, Lightdale CJ, Sherlock P, Melamed M and Fortner JG: Endoscopic diagnosis of advanced gastric cancer. Factors influencing yield. Gastroenterology. 69:1183–1187. 1975.PubMed/NCBI
10	An-Foraker SH and Vise D: Cytodiagnosis of gastric carcinoma, linitis plastica type (diffuse, infiltrating, poorly differentiated adenocarcinoma). Acta Cytol. 25:361–366. 1981.PubMed/NCBI
11	Levine MS, Kong V, Rubesin SE, Laufer I and Herlinger H: Scirrhous carcinoma of the stomach: radiologic and endoscopic diagnosis. Radiology. 175:151–154. 1990. View Article : Google Scholar : PubMed/NCBI
12	Evans E, Harris O, Dickey D and Hartley L: Difficulties in the endoscopic diagnosis of gastric and oesophageal cancer. Aust N Z J Surg. 55:541–544. 1985. View Article : Google Scholar : PubMed/NCBI
13	Maruyama Y, Kageoka M, Nagata K, et al: Endoscopic diagnosis based on typical findings of scirrhous gastric cancer. Stomach Intestine. 45:445–455. 2010.
14	Murata Y, Yamasaki T, Kitamura Y, et al: Diagnostic points of endoscopic ultrasonographic findings in scirrhous gastric cancer. Stomach Intestine. 45:457–467. 2010.
15	Park MS, Ha HK, Choi BS, et al: Scirrhous gastric carcinoma: endoscopy versus upper gastrointestinal radiography. Radiology. 231:421–426. 2004. View Article : Google Scholar : PubMed/NCBI
16	Yamamoto T, Nagahama R, Nakashima H, et al: Basis of the diagnosis and feature of scirrhous gastric cancer. Stomach Intestine. 45:428–444. 2010.
17	Kodera Y, Nakanishi H, Ito S, et al: Detection of disseminated cancer cells in linitis plastica-type gastric carcinoma. Jpn J Clin Oncol. 34:525–531. 2004. View Article : Google Scholar : PubMed/NCBI
18	Kobara H, Mori H, Rafiq K, et al: Evaluation of gastric submucosal tumors using endoscopically visualized features with submucosal endoscopy. Oncol Lett. 8:161–168. 2014.PubMed/NCBI
19	Kobara H, Mori H, Fujihara S, et al: Bloc biopsy by using submucosal endoscopy with a mucosal flap method for gastric subepithelial tumor tissue sampling (with video). Gastrointest Endosc. 77:141–145. 2013. View Article : Google Scholar
20	Kobara H, Mori H, Fujiwara S, Nishiyama N, Kobayashi M and Masaki T: Bloc biopsy by tunneling method using endoscopic submucosal dissection for an upper gastrointestinal submucosal tumor. Endoscopy. 44(Suppl 2): S197–S198. 2012. View Article : Google Scholar

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Characteristic waffle-like appearance of gastric linitis plastica: A case report

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