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Craniopharyngioma: Survivin expression and ultrastructure

  • Authors:
    • Jiang Zhu
    • Chao You
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, P.R. China
  • Pages: 75-80
    |
    Published online on: November 7, 2014
       https://doi.org/10.3892/ol.2014.2690
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Abstract

The aim of the present study was to investigate the significance of survivin protein expression levels in craniopharyngioma. Tumor samples and clinical data were obtained from 50 patients with craniopharyngioma who were admitted to the West China Hospital of Sichuan University (Chengdu, China). The morphology of the craniopharyngioma samples was observed using optical and electron microscopes, and survivin expression was investigated in the samples by immunohistochemical analysis. The immunohistochemical results revealed survivin expression in all of the craniopharyngioma samples, but not in the healthy brain tissue samples. It was identified that survivin was expressed at a higher level in cases of the adamantinomatous type compared with those of the squamous‑papillary type, in male patients compared with female patients, in children compared with adults and in recurrent cases compared with non‑recurrent cases. Furthermore, no significant difference was detected in survivin expression levels among the tumors of different subtypes and different disease stages. The results of the present study indicate that survivin is significant in the development of craniopharyngioma, and that survivin protein expression levels are a meaningful indicator for assessing craniopharyngioma recurrence.
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Copy and paste a formatted citation
Spandidos Publications style
Zhu J and You C: Craniopharyngioma: Survivin expression and ultrastructure. Oncol Lett 9: 75-80, 2015.
APA
Zhu, J., & You, C. (2015). Craniopharyngioma: Survivin expression and ultrastructure. Oncology Letters, 9, 75-80. https://doi.org/10.3892/ol.2014.2690
MLA
Zhu, J., You, C."Craniopharyngioma: Survivin expression and ultrastructure". Oncology Letters 9.1 (2015): 75-80.
Chicago
Zhu, J., You, C."Craniopharyngioma: Survivin expression and ultrastructure". Oncology Letters 9, no. 1 (2015): 75-80. https://doi.org/10.3892/ol.2014.2690
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu J and You C: Craniopharyngioma: Survivin expression and ultrastructure. Oncol Lett 9: 75-80, 2015.
APA
Zhu, J., & You, C. (2015). Craniopharyngioma: Survivin expression and ultrastructure. Oncology Letters, 9, 75-80. https://doi.org/10.3892/ol.2014.2690
MLA
Zhu, J., You, C."Craniopharyngioma: Survivin expression and ultrastructure". Oncology Letters 9.1 (2015): 75-80.
Chicago
Zhu, J., You, C."Craniopharyngioma: Survivin expression and ultrastructure". Oncology Letters 9, no. 1 (2015): 75-80. https://doi.org/10.3892/ol.2014.2690
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