Peripheral primitive neuroectodermal tumor of the kidney in a 51‑year‑old female following breast cancer: A case report and review of the literature

Zhong,Jinjing; Chen,Ni; Chen,Xueqin; Gong,Jing; Nie,Ling; Xu,Miao; Zhou,Qiao

doi:10.3892/ol.2014.2695

January-2015 Volume 9 Issue 1

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January-2015 Volume 9 Issue 1

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Peripheral primitive neuroectodermal tumor of the kidney in a 51‑year‑old female following breast cancer: A case report and review of the literature

Authors:
- Jinjing Zhong
- Ni Chen
- Xueqin Chen
- Jing Gong
- Ling Nie
- Miao Xu
- Qiao Zhou
View Affiliations / Copyright

Affiliations: Department of Pathology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, P.R. China
Pages: 108-112
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Published online on: November 10, 2014

https://doi.org/10.3892/ol.2014.2695
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Abstract

Peripheral primitive neuroectodermal tumor/Ewing's sarcoma (pPNET/EWS) is an aggressive type of sarcoma that is rarely observed in the kidney. pPNET of the kidney principally occurs in young patients (<50 years old) and is very rare in older patients (≥50 years old). Additionally, only six cases of pPNET of the kidney have been reported in the literature in older patients (≥50 years old), and pPNET as a secondary primary tumor has rarely been reported. The current study presents a case of renal pPNET in a 51‑year‑old female who had been surgically treated for breast carcinoma and administered with adjuvant chemotherapy five years prior to hospitalization for pPNET. A computed tomography scan identified a tumor in the lower pole of the right kidney, which was treated by nephrectomy. Immunohistochemistry demonstrated diffuse, strong membranous positivity for cluster of differentiation (CD)99, positive nuclear staining for friend leukemia integration 1, and negative staining for Wilms' tumor 1 and other markers. Fluorescence in situ hybridization (FISH) analysis of the EWS breakpoint region 1 (EWSR1) demonstrated the characteristic EWSR1 translocation. The patient declined chemotherapy or radiotherapy but accepted traditional Chinese medicine. No evidence of recurrence was observed eight months after diagnosis. Only two cases of renal pPNET with a history of an earlier or synchronous primary cancer were reported in the literature from the USA and Germany, respectively. To the best of our knowledge, the present case is the first FISH‑confirmed renal pPNET in an older patient following breast adenocarcinoma.

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1	Marley EF, Liapis H, Humphrey PA, et al: Primitive neuroectodermal tumor of the kidney - another enigma: a pathologic, immunohistochemical, and molecular diagnostic study. Am J Surg Pathol. 21:354–359. 1997. View Article : Google Scholar : PubMed/NCBI
2	Howe HL, Wu X, Ries LA, et al: Annual report to the nation on the status of cancer, 1975–2003, featuring cancer among U.S. Hispanic/Latino populations. Cancer. 107:1711–1742. 2006. View Article : Google Scholar : PubMed/NCBI
3	Tsokos M, Alaggio RD, Dehner LP and Dickman PS: Ewing sarcoma/peripheral primitive neuroectodermal tumor and related tumors. Pediatr Dev Pathol. (Suppl 1)15:108–126. 2012. View Article : Google Scholar : PubMed/NCBI
4	Movahedi-Lankarani S, Hruban RH, Westra WH and Klimstra DS: Primitive neuroectodermal tumors of the pancreas: a report of seven cases of a rare neoplasm. Am J Surg Pathol. 26:1040–1047. 2002. View Article : Google Scholar : PubMed/NCBI
5	Mani S, Dutta D and De BK: Primitive neuroectodermal tumor of the liver: a case report. Japanese J Clin Oncol. 40:258–262. 2010. View Article : Google Scholar
6	Seemayer TA, Thelmo WL, Bolande RP and Wiglesworth FW: Peripheral neuroectodermal tumors. Perspect Pediatr Pathol. 2:151–172. 1975.PubMed/NCBI
7	Zöllner S, Dirksen U, Jürgens H and Ranft A: Renal Ewing tumors. Ann Oncol. 24:2455–2461. 2013. View Article : Google Scholar : PubMed/NCBI
8	Risi E, Iacovelli R, Altavilla A, et al: Clinical and pathological features of primary neuroectodermal tumor/Ewing sarcoma of the kidney. Urology. 82:382–386. 2013. View Article : Google Scholar : PubMed/NCBI
9	Jimenez RE, Folpe AL and Lapham RL: Primary Ewing’s sarcoma/primitive neuroectodermal tumor of the kidney: a clinicopathologic and immunohistochemical analysis of 11 cases. Am J Surg Pathol. 26:320–327. 2002. View Article : Google Scholar : PubMed/NCBI
10	Eggers H, Waalkes S, von Klot C, Trankenschuh W, Merseburger AS and Herrmann TR: Ewing’s sarcoma of the kidneys with simultaneous seminoma. Urologe A. 50:205–207. 2011.(In German). View Article : Google Scholar : PubMed/NCBI
11	Tariq Z, Ghose A, Sofi A, Mohamed I and Harmon D: Metastatic renal extraskeletal Ewing sarcoma in complete remission for the last 8 years. Am J Ther. 19:120–121. 2012. View Article : Google Scholar
12	Mandal PK, Mukherjee S, Roy S and Bhattacharyya NK: PNET of kidney: Report of four cases. Indian J Med Paediatr Oncol. 33:130–133. 2012. View Article : Google Scholar : PubMed/NCBI
13	Wedde TB, Lobmaier IV, Brennhovd B, Lohne F and Hall KS: Primary Ewing’s sarcoma of the kidney in a 73-year-old man. Sarcoma. 2011:9783192011. View Article : Google Scholar
14	Koski ME, Tedesco JM and Clark PE: Renal peripheral neuroectodermal tumor presenting at age 78: case report. Scientific World Journal. 8:830–834. 2008. View Article : Google Scholar : PubMed/NCBI
15	Parham DM, Roloson GJ, Feely M, Green DM, Bridge JA and Beckwith JB: Primary malignant neuroepithelial tumors of the kidney: a clinicopathologic analysis of 146 adult and pediatric cases from the National Wilms’ Tumor Study Group Pathology Center. Am J Surg Pathol. 25:133–146. 2001. View Article : Google Scholar : PubMed/NCBI
16	Saxena R, Sait S and Mhawech-Fauceglia P: Ewing sarcoma/primitive neuroectodermal tumor of the kidney: a case report. Diagnosed by immunohistochemistry and molecular analysis. Ann Diagn Pathol. 10:363–366. 2006. View Article : Google Scholar : PubMed/NCBI
17	Sorensen PH, Liu XF, Delattre O, et al: Reverse transcriptase PCR amplification of EWS/FLI-1 fusion transcripts as a diagnostic test for peripheral primitive neuroectodermal tumors of childhood. Diagn Mol Pathol. 2:147–157. 1993. View Article : Google Scholar : PubMed/NCBI
18	Wasylyk B, Hahn SL and Giovane A: The Ets family of transcription factors. Eur J Biochem. 211:7–18. 1993. View Article : Google Scholar : PubMed/NCBI
19	Franzetti GA, Laud-Duval K, Bellanger D, Stern MH, Sastre-Garau X and Delattre O: MiR-30a-5p connects EWS-FLI1 and CD99, two major therapeutic targets in Ewing tumor. Oncogene. 32:3915–3921. 2013. View Article : Google Scholar
20	Berg T, Kalsaas AH, Buechner J and Busund LT: Ewing sarcoma-peripheral neuroectodermal tumor of the kidney with a FUS-ERG fusion transcript. Cancer Genet Cytogenet. 194:53–57. 2009. View Article : Google Scholar : PubMed/NCBI
21	Angel J, Alfred A, Sakhuja A, Sells RE and Zechlinkski JJ: Ewing’s sarcoma of the kidney. Int J Clin Oncol. 15:314–318. 2010. View Article : Google Scholar : PubMed/NCBI
22	Ishii H and Ogaki K: Primitive neuroectodermal tumor of the kidney. Med Mol Morphol. 42:175–179. 2009. View Article : Google Scholar : PubMed/NCBI
23	Thyavihally YB, Tongaonkar HB, Gupta S, et al: Primitive neuroectodermal tumor of the kidney: a single institute series of 16 patients. Urology. 71:292–296. 2008. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Peripheral primitive neuroectodermal tumor of the kidney in a 51‑year‑old female following breast cancer: A case report and review of the literature

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