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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Antitumor effect of D-erythrose in an abdominal metastatic model of colon carcinoma

  • Authors:
    • Li‑Li Liu
    • Tao Yi
    • Xia Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology and Obstetrics, Key Laboratory of Obstetric, Gynecological and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China
  • Pages: 769-773
    |
    Published online on: December 3, 2014
       https://doi.org/10.3892/ol.2014.2764
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Abstract

Traditional chemotherapy drugs against colorectal cancer possess little or no specificity, leading to severe intolerable side‑effects. Therefore, it is necessary to develop additional specific therapeutic strategies. It has been suggested that D‑erythrose may specifically inhibit the growth of tumor cells. However, the in vivo antitumor effect of D‑erythrose against colorectal cancer remains unknown. Thus, the present study investigated the antitumor effect of D‑erythrose in an abdominal metastatic model of colon carcinoma. Intraperitoneal (IP) colon carcinoma‑bearing BALB/c mice received an IP injection of D‑erythrose or normal saline (NS) daily for 15 days. The mice were weighed every three days. The tumor weights and the volume of ascites were evaluated following the treatment. Terminal deoxynucleotidyl transferase‑mediated dUTP nick end labeling assay was used to assess apoptosis in tumor tissues. The results revealed that D‑erythrose significantly reduced the weight of the intraperitoneal tumor by 69.1%, markedly inhibited the development of ascites and increased tumor cell apoptosis, without any observed toxic effects. These observations suggest that D‑erythrose possesses antitumor activity against colon cancer. The present study may provide a potentially effective and specific approach for colon cancer treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Liu LL, Yi T and Zhao X: Antitumor effect of D-erythrose in an abdominal metastatic model of colon carcinoma. Oncol Lett 9: 769-773, 2015.
APA
Liu, L., Yi, T., & Zhao, X. (2015). Antitumor effect of D-erythrose in an abdominal metastatic model of colon carcinoma. Oncology Letters, 9, 769-773. https://doi.org/10.3892/ol.2014.2764
MLA
Liu, L., Yi, T., Zhao, X."Antitumor effect of D-erythrose in an abdominal metastatic model of colon carcinoma". Oncology Letters 9.2 (2015): 769-773.
Chicago
Liu, L., Yi, T., Zhao, X."Antitumor effect of D-erythrose in an abdominal metastatic model of colon carcinoma". Oncology Letters 9, no. 2 (2015): 769-773. https://doi.org/10.3892/ol.2014.2764
Copy and paste a formatted citation
x
Spandidos Publications style
Liu LL, Yi T and Zhao X: Antitumor effect of D-erythrose in an abdominal metastatic model of colon carcinoma. Oncol Lett 9: 769-773, 2015.
APA
Liu, L., Yi, T., & Zhao, X. (2015). Antitumor effect of D-erythrose in an abdominal metastatic model of colon carcinoma. Oncology Letters, 9, 769-773. https://doi.org/10.3892/ol.2014.2764
MLA
Liu, L., Yi, T., Zhao, X."Antitumor effect of D-erythrose in an abdominal metastatic model of colon carcinoma". Oncology Letters 9.2 (2015): 769-773.
Chicago
Liu, L., Yi, T., Zhao, X."Antitumor effect of D-erythrose in an abdominal metastatic model of colon carcinoma". Oncology Letters 9, no. 2 (2015): 769-773. https://doi.org/10.3892/ol.2014.2764
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