Synovial sarcoma: Magnetic resonance and computed tomography imaging features and differential diagnostic considerations

Liang,Changhua; Mao,Huajie; Tan,Jing; Ji,Yinghua; Sun,Fengxia; Dou,Wenguang; Wang,Huifang; Wang,Hongpo; Gao,Jianbo

doi:10.3892/ol.2014.2774

February-2015 Volume 9 Issue 2

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

February-2015 Volume 9 Issue 2

Full Size Image

Article

Synovial sarcoma: Magnetic resonance and computed tomography imaging features and differential diagnostic considerations

Authors:
- Changhua Liang
- Huajie Mao
- Jing Tan
- Yinghua Ji
- Fengxia Sun
- Wenguang Dou
- Huifang Wang
- Hongpo Wang
- Jianbo Gao
View Affiliations / Copyright

Affiliations: Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China, Imaging Center, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan 453100, P.R. China, Department of Internal Medicine, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China
Pages: 661-666
|
Published online on: December 5, 2014

https://doi.org/10.3892/ol.2014.2774
Expand metrics +

Abstract

The present study retrospectively examined 24 cases of pathologically confirmed synovial sarcoma and analyzed the clinical presentation and imaging findings in order to explore the imaging features of synovial sarcoma. The majority of the lesions were large (>5 cm; 88%), rounded or lobulated, relatively well‑defined tumor masses in the extremities near the joints or deeply located. On computed tomography (CT) scans, the lesions demonstrated intensity signals similar to those of muscle. Six cases exhibited punctate calcification in the periphery of the tumor. On T1‑weighted images, the largest lesions of >5 cm, were usually heterogeneous, with a signal intensity similar to or slightly higher than that of muscle. On T2‑weighted images, heterogeneous high‑intensity or slightly high‑intensity signals were observed, with 12 cases exhibiting a high signal consistent with hemorrhage and 12 presenting signals that indicated internal septations. Contrast‑enhanced scanning revealed heterogeneous enhancement in the majority of the lesions and no enhancement in areas of cystic necrosis or internal septations. Synovial sarcoma has specific imaging features, and comprehensive analysis of CT and magnetic resonance imaging can improve the accuracy of the pre‑operative diagnosis.

View Figures

View References

1	Fisher C, de Brujin DRH and van Kessel AG: Synovial sarcoma. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. Fletcher CDM, Unni KK and Mertens F: IARC Press; Lyon: pp. 200–204. 2002
2	Wu Z and Huang XZ: Clinical study of 72 cases of synovial sarcoma. Chin Clin Oncol. 9:84–85. 2004.(In Chinese).
3	Fisher C: Synovial sarcoma. Ann Diagn Pathol. 2:401–421. 1998. View Article : Google Scholar
4	Liu GR, Huang YS, Lan BW and He ZH: Imaging diagnosis of synoviosarcoma (report of 10 cases). J Diagn Imaging Interv Radiol. 10:83–85. 2001.
5	Zhu XZ: Current WHO classification of soft tissue tumor. Diagn Interv Imaging. 19:94–96. 2003.
6	Zhang ZH, Meng QF and Zhang XL: MRI diagnosis of synovial sarcoma of extremities. J Clin Radiol. 25:941–944. 2006.
7	McCarville MB, Spunt SL, Skapek SX and Pappo AS: Synovial sarcoma in pediatric patients. AJR Am J Roentgenol. 179:797–801. 2002. View Article : Google Scholar : PubMed/NCBI
8	O’Sullivan PJ, Harris AC and Munk PL: Radiological features of synovial cell sarcoma. Br J Radiol. 81:346–356. 2008. View Article : Google Scholar
9	Li F, Wang RF, Qi L, et al: Synovial sarcoma of soft tissues: a CT and MRI study. Radiologic Practice. 25:1396–1399. 2010.
10	Van Hul E, Vanhoenacker F, Van Dyck P, De Schepper A and Parizel PM: Pseudotumoural soft tissue lesions of the foot and ankle: a pictorial review. Insights into Imaging. 2:439–452. 2011. View Article : Google Scholar
11	Ren XH, Wu XM, Jin C and Cui YA: Diagnosis and treatment progress of synovial sarcoma. Medical Recapitulate. 15:541–542. 2009.
12	Kransdorf MJ: Malignant soft-tissue tumors in a large referral population: distribution of diagnoses by age, sex, and location. AJR Am J Roentgenol. 164:129–134. 1995. View Article : Google Scholar : PubMed/NCBI
13	Tateishi U, Hasegawa T, Beppu Y, Satake M and Moriyama N: Synovial sarcoma of the soft tissues: prognostic significance of imaging features. J Comput Assist Tomogr. 28:140–148. 2004. View Article : Google Scholar : PubMed/NCBI
14	Bhosale P, Balachandran A and Tamm E: Imaging of benign and malignant cystic pancreatic lesions and a strategy for follow up. World J Radiol. 2:345–353. 2010. View Article : Google Scholar : PubMed/NCBI
15	Jones BC, Sundaram M and Kransdorf MJ: Synovial sarcoma: MR imaging findings in 34 patients. AJR Am J Roentgenol. 161:827–830. 1993. View Article : Google Scholar : PubMed/NCBI
16	Chen JY, Liu QY, Ye RX, Zhong JL and Liang BL: Correlation of MR imaging features and histopathology of synovial sarcoma. Ai Zheng. 24:87–90. 2005.PubMed/NCBI
17	Marzano L, Failoni S, Gallazzi M and Garbagna P: The role of diagnostic imaging in synovial sarcoma. Our experience. Radiol Med. 107:533–540. 2004.PubMed/NCBI
18	Fang TS, Xu YK, Peng JY and Fan CS: Imaging analysis of synovial sarcoma of extremities. J Chin Clin Med Imaging. 2:106–109. 2009.
19	Rangheard AS, Vanel D, Viala J, Schwaab G, Casiraghi O and Sigal R: Synovial sarcomas of the head and neck: CT and MR imaging findings of eight patients. AJNR Am J Neuroradiol. 22:851–857. 2001.PubMed/NCBI
20	Koehler SM, Beasley MB, Chin CS, Wittig JC, Hecht AC and Qureshi SA: Synovial sarcoma of the thoracic spine. Spine J. 9:e1–e6. 2009. View Article : Google Scholar : PubMed/NCBI
21	Shaariyah MM, Mazita A, Masaany M, Razif MY, Isa MR and Asma A: Synovial sarcoma: a rare presentation of parapharyngeal mass. Chin J Cancer. 29:631–633. 2010. View Article : Google Scholar : PubMed/NCBI
22	Huang ZT, Chen WG, Jia M, et al: One case: synovial sarcoma of adnexal bone in the third thoracic vertebra. J Pract Radiol. 12:1563–1564. 2006.
23	Brisse HJ, Orbach D and Klijanienko J: Soft tissue tumours: imaging strategy. Pediatr Radiol. 40:1019–1028. 2010. View Article : Google Scholar : PubMed/NCBI
24	Cormier JN and Pollock RE: Soft tissue sarcomas. CA Cancer J Clin. 54:94–109. 2004. View Article : Google Scholar : PubMed/NCBI
25	Vander Salm TJ: Unusual primary tumors of the heart. Semin Thorac Cardiovasc Surg. 12:89–100. 2000. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Synovial sarcoma: Magnetic resonance and computed tomography imaging features and differential diagnostic considerations

This article is mentioned in:

Abstract

Figure 1

Figure 2

Figure 3

Figure 4

Related Articles