CD14+HLA-DRlow/‑ expression: A novel prognostic factor in chronic lymphocytic leukemia

Liu,Jinlin; Zhou,Yonglie; Huang,Qiang; Qiu,Liannv

doi:10.3892/ol.2014.2808

March-2015 Volume 9 Issue 3

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March-2015 Volume 9 Issue 3

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Article

CD14+HLA-DRlow/‑ expression: A novel prognostic factor in chronic lymphocytic leukemia

Authors:
- Jinlin Liu
- Yonglie Zhou
- Qiang Huang
- Liannv Qiu
View Affiliations / Copyright

Affiliations: Department of Clinical Laboratory, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310004, P.R. China, Department of Hematology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310004, P.R. China
Pages: 1167-1172
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Published online on: December 17, 2014

https://doi.org/10.3892/ol.2014.2808
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Abstract

Currently, no prognostic factors exist for determining the host immune status of chronic lymphocytic leukemia (CLL) patients. Therefore, the present report analyzed cluster of differentiation 14 (CD14)+ human leukocyte antigen (HLA)‑DRlow/‑ myeloid‑derived suppressor cells (MDSC) from 49 CLL patients and demonstrated that these cells were significantly expanded in all CLL patients when compared with monoclonal B cell lymphocytosis patients and healthy volunteers. Furthermore, upregulation of CD14+HLA‑DRlow/‑ MDSCs was correlated with CLL tumor progression and a poor prognosis for CLL patients, and CD14+HLA‑DRlow/‑ MDSCs were significantly correlated with the presence of CD4+ T and CD5+CD19+ cells in CLL patients, which could significantly inhibit the CD4+ T‑cell immune response, contributing to CLL cell progression in CLL patients.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

CD14+HLA-DRlow/‑ expression: A novel prognostic factor in chronic lymphocytic leukemia

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