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Article

Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging: A potential utility for the evaluation of regional liver function impairment following transcatheter arterial chemoembolization

  • Authors:
    • Yu‑Dong Xiao
    • Ramchandra Paudel
    • Huan Liu
    • Bin Zhang
    • Cong Ma
    • Shun‑Ke Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R. China
  • Pages: 1191-1196
    |
    Published online on: December 23, 2014
       https://doi.org/10.3892/ol.2014.2826
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Abstract

The present study aimed to evaluate regional liver function impairment following transcatheter arterial chemoembolization (TACE), assessed by magnetic resonance imaging (MRI) enhanced by gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd‑EOB‑DTPA). Additionally, this study evaluated the associations between signal intensity and various clinical factors. A prospective study was conducted between March 2012 and May 2013 with a total of 35 patients. Gd‑EOB‑DTPA‑enhanced MRI was performed 3‑5 days after TACE therapy. The signal to noise ratio (SNR) was subsequently calculated for healthy liver tissue regions and peritumoral regions, prior to and 20 min after Gd‑EOB‑DTPA administration. The correlation between clinical factors and relative SNR was assessed using Pearson's correlation coefficient or Spearman's rank correlation coefficient. Prior to Gd‑EOB‑DTPA administration, the SNR values showed no significant difference (t=1.341, P=0.191) in healthy liver tissue regions (50.53±15.99; range, 11.25‑83.46) compared with peritumoral regions (49.81±15.85; range, 12.34‑81.53). On measuring at 20 min following Gd‑EOB‑DTPA administration, the SNR in healthy liver tissue regions (82.55±33.33; range, 31.45‑153.02) was significantly higher (t=3.732, P<0.001) compared with that in peritumoral regions (75.77±27.41; range, 31.42‑144.49). The relative SNR in peritumoral regions correlated only with the quantity of iodized oil used during TACE therapy (r=0.528, P=0.003); the age, gender, diameter and blood supply of the tumor, or Child‑Pugh class of the patient did not correlate with relative SNR. Gd‑EOB‑DTPA‑enhanced MRI may be an effective way to evaluate regional liver function impairment following TACE therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Xiao YD, Paudel R, Liu H, Zhang B, Ma C and Zhou SK: Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging: A potential utility for the evaluation of regional liver function impairment following transcatheter arterial chemoembolization. Oncol Lett 9: 1191-1196, 2015.
APA
Xiao, Y., Paudel, R., Liu, H., Zhang, B., Ma, C., & Zhou, S. (2015). Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging: A potential utility for the evaluation of regional liver function impairment following transcatheter arterial chemoembolization. Oncology Letters, 9, 1191-1196. https://doi.org/10.3892/ol.2014.2826
MLA
Xiao, Y., Paudel, R., Liu, H., Zhang, B., Ma, C., Zhou, S."Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging: A potential utility for the evaluation of regional liver function impairment following transcatheter arterial chemoembolization". Oncology Letters 9.3 (2015): 1191-1196.
Chicago
Xiao, Y., Paudel, R., Liu, H., Zhang, B., Ma, C., Zhou, S."Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging: A potential utility for the evaluation of regional liver function impairment following transcatheter arterial chemoembolization". Oncology Letters 9, no. 3 (2015): 1191-1196. https://doi.org/10.3892/ol.2014.2826
Copy and paste a formatted citation
x
Spandidos Publications style
Xiao YD, Paudel R, Liu H, Zhang B, Ma C and Zhou SK: Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging: A potential utility for the evaluation of regional liver function impairment following transcatheter arterial chemoembolization. Oncol Lett 9: 1191-1196, 2015.
APA
Xiao, Y., Paudel, R., Liu, H., Zhang, B., Ma, C., & Zhou, S. (2015). Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging: A potential utility for the evaluation of regional liver function impairment following transcatheter arterial chemoembolization. Oncology Letters, 9, 1191-1196. https://doi.org/10.3892/ol.2014.2826
MLA
Xiao, Y., Paudel, R., Liu, H., Zhang, B., Ma, C., Zhou, S."Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging: A potential utility for the evaluation of regional liver function impairment following transcatheter arterial chemoembolization". Oncology Letters 9.3 (2015): 1191-1196.
Chicago
Xiao, Y., Paudel, R., Liu, H., Zhang, B., Ma, C., Zhou, S."Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging: A potential utility for the evaluation of regional liver function impairment following transcatheter arterial chemoembolization". Oncology Letters 9, no. 3 (2015): 1191-1196. https://doi.org/10.3892/ol.2014.2826
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