Penile mucinous carcinoma: A case report
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Affiliations: Department of Urology, School of Medicine, Sifa University, Izmir 35240, Turkey
- Published online on: December 30, 2014 https://doi.org/10.3892/ol.2014.2839
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1293-1296
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Abstract
Penile cancer is an extremely rare form of urological cancer that usually originates in the epithelium of the inner preputium or glans. Major etiological factors include phimosis, poor penile hygiene and smoking. Nearly 95% of penile cancers are squamous cell carcinomas and usually occur in the sixth decade of life. The disease exhibits two variants, namely metastatic and atypical disease. Squamous differentiation may also present with mucinous metaplasia. An extremely limited number of case reports on penile cancer are available in the literature. The present study reports the case of a 39‑year‑old patient with penile mucinous adenocarcinoma who was admitted with the complaint of perineal discharge, which is, to the best of our knowledge, the first case in the literature. The patient underwent total penectomy and inguinal lymph node dissection. The tumor was staged as T4N1M0, according to the European Association of Urology's tumor‑node‑metastasis classification system. The patient was treated with pelvic radiotherapy and six cycles of systemic neoadjuvant chemotherapy with cisplatin and paclitaxel simultaneously, over a period of four months. After nine months of follow-up the patient succumbed to the disease due to widespread metastases.
View References
|
1
|
Barnholtz-Sloan JS, Maldonado JL, Pow-Sang
J and Giuliano AR: Incidence trends in primary malignant penile
cancer. Urol Oncol. 25:361–367. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Parkin DM, Whelan SL, Ferlay J, et al:
Cancer Incidence in Five Continents. VIII:http://www.iarc.fr/en/Publications/PDFs-online/Cancer-Epidemiology/IARC-ScientificPublication-No.-155"ref-label" rowspan="1" colspan="1">
3
|
Pizzocaro G, Algaba F, Horenblas S, et al:
EAU penile cancer guidelines 2009. Eur Urol. 57:1002–1012. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Bezerra AL, Lopes A, Santiago GH, et al:
Human papillomavirus as a prognostic factor in carcinoma of the
penis: analysis of 82 patients treated with amputation and
bilateral lymphadenectomy. Cancer. 91:2315–2321. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Kayes O, Ahmed HU, Arya M and Minhas S:
Molecular and genetic pathways in penile cancer. Lancet Oncol.
8:420–429. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Van Howe RS and Hodges FM: The
carcinogenicity of smegma: debunking a myth. Eur Acad Dermatol
Venereol. 20:1046–1054. 2006. View Article : Google Scholar
|
|
7
|
Velazquez EF and Cubilla AL: Lichen
sclerosus in 68 patients with squamous cell carcinoma of the penis:
frequent atypias and correlation with special carcinoma variants
suggests a precancerous role. Am Surg Pathol. 27:1448–1453. 2003.
View Article : Google Scholar
|
|
8
|
Ranganath R, Singh SS and Sateeshan B:
Sarcomatoid carcinoma of the penis: clinicopathologic features.
Indian J Urol. 24:267–268. 2008. View Article : Google Scholar
|
|
9
|
Ruiz-Genao DP, Daudén-Tello E, Adrados M,
Fraga J and García-Díez A: Mucinous metaplasia of the glans penis.
Histopathology. 44:90–91. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Val-Bernal JF and Hernández-Nieto E:
Benign mucinous metaplasia of the penis. A lesion resembling
extramammary Paget’s disease. J Cutan Pathol. 27:76–79. 2000.
View Article : Google Scholar : PubMed/NCBI
|
|
11
|
García-Abós M, Fraga J and Daudén E:
Mucinous metaplasia of the penis associated with Zoon’s balanitis.
Actas Dermosifiliogr. 101:362–364. 2010. View Article : Google Scholar
|
|
12
|
Fang AW, Whittaker MA and Theaker JM:
Mucinous metaplasia of the penis. Histopathology. 40:177–179. 2002.
View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Tong PL, Delaney TA and Beer TW:
Erythematous shiny plaque over the glans penis. Arch Dermatol.
147:735–740. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Lai JP, Cowen EW, Jere B, et al: Zoon’s
balanitis with mucinous metaplasia: A case report and review of
literature. Open J Clin Diag. 3:33–36. 2013. View Article : Google Scholar
|
