Hepatoid adenocarcinoma of the stomach: A case report and review of the literature

Zhou,Ru; Cai,Yantao; Yang,Yi; Xiang,Jianbin; Chen,Zongyou

doi:10.3892/ol.2015.2979

Hepatoid adenocarcinoma of the stomach: A case report and review of the literature

Authors:
- Ru Zhou
- Yantao Cai
- Yi Yang
- Jianbin Xiang
- Zongyou Chen
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Affiliations: Department of General Surgery, Luwan Branch, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200020, P.R. China, Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China
Published online on: February 20, 2015 https://doi.org/10.3892/ol.2015.2979
Pages: 2126-2128

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Abstract

Hepatoid adenocarcinoma is a rare tumor, associated with an extremely poor prognosis. In the present report, a 72‑year‑old female presented to Huashan Hospital (Shanghai, China) with upper abdominal discomfort and, following endoscopy, an ulcerated lesion was observed in the stomach. A computed tomography scan revealed a mass in the antrum of the stomach and the α‑fetoprotein level was normal. Sections of the mass exhibited malignant cells arranged in a solid to trabecular pattern; the cells were polygonal shaped with well‑defined cytoplasmic borders. Immunohistochemical analysis was performed and the cells were positive for Hep1, CK, CK8, CK18 and P53. The histological features together with the immunohistochemical findings were diagnostic of a hepatoid adenocarcinoma of the stomach. Immunohistochemical studies may aid in the identification of the characteristic features and prevent the misdiagnosis of this tumor.

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