Primary non-gestational pure choriocarcinoma arising in the ovary: A case report and literature review

Hayashi,Shinichi; Abe,Yoshiro; Tomita,Shigeki; Nakanishi,Yuko; Miwa,Shigeharu; Nakajima,Takahiko; Nomoto,Kazuhiro; Tsuneyama,Koichi; Fujimori,Takahiro; Imura,Johji

doi:10.3892/ol.2015.2985

May-2015 Volume 9 Issue 5

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May-2015 Volume 9 Issue 5

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Case Report

Primary non-gestational pure choriocarcinoma arising in the ovary: A case report and literature review

Authors:
- Shinichi Hayashi
- Yoshiro Abe
- Shigeki Tomita
- Yuko Nakanishi
- Shigeharu Miwa
- Takahiko Nakajima
- Kazuhiro Nomoto
- Koichi Tsuneyama
- Takahiro Fujimori
- Johji Imura
View Affiliations / Copyright

Affiliations: Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Toyama 930‑0194, Japan, Department of Neurosurgery, Dokkyo University School of Medicine, Tochigi 321‑0293, Japan, Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Tochigi 321‑0293, Japan
Pages: 2109-2111
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Published online on: February 26, 2015

https://doi.org/10.3892/ol.2015.2985
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Abstract

Pure non‑gestational choriocarcinoma is a primary germ cell neoplasm that has been defined as a tumor without other germ cell elements. The current study presents an extremely rare case of non‑gestational pure choriocarcinoma in a postmenarcheal young female and describes details of the tumor, including the clinicopathological findings. The patient was a 10‑year‑old female who underwent salpingo‑oophorectomy. Histologically, the extensive hemorrhagic tumor was composed of choriocarcinoma without additional germ cell tumor components. The tumor cells were immunohistochemically positive for epithelial markers, including cytokeratins and epithelial membrane antigens, and there was a positive cytoplasmic reaction for β‑human chorionic gonadotropin in the syncytiotrophoblasts. Furthermore, numerous tumor cells were immunohistochemically positive for the β2‑microglobulin antibody. The patient received adjuvant cisplatin, etoposide and bleomycin chemotherapy, and is currently disease‑free without evidence of recurrence or metastasis subsequent to 62 months of follow‑up.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Primary non-gestational pure choriocarcinoma arising in the ovary: A case report and literature review

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