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Article

High performance liquid chromatography: Tandem mass spectrometric determination of cisplatin levels in different visceral pleura layers of rats

  • Authors:
    • Hui Xia
    • Wen Zhang
    • Yingjie Li
    • Changhai Yu
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic‑Cardio Surgery, First Affiliated Hospital of PLA General Hospital, Beijing 100048, P.R. China
  • Pages: 2388-2392
    |
    Published online on: February 26, 2015
       https://doi.org/10.3892/ol.2015.2989
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Abstract

The aim of the present study was to investigate the concentration of cisplatin in different layers of the visceral pleura in rats, following drug administration. In this study, a sensitive and specific liquid chromatography method coupled with electrospray ionization‑tandem mass spectrometry was established to investigate the disposition of cisplatin in different layers of the visceral pleura in rats. Methodological data, including specificity, linearity, accuracy, recovery, precision and lower limits of quantification, confirmed that this novel method may be used to efficiently quantify the cisplatin concentrations in visceral pleura of rats following administration of the drug. Furthermore, the results demonstrated that the desired drug concentration was not achieved in the outer or inner elastic layers of the visceral pleura following injection with cisplatin through various administration methods.
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Copy and paste a formatted citation
Spandidos Publications style
Xia H, Zhang W, Li Y and Yu C: High performance liquid chromatography: Tandem mass spectrometric determination of cisplatin levels in different visceral pleura layers of rats. Oncol Lett 9: 2388-2392, 2015.
APA
Xia, H., Zhang, W., Li, Y., & Yu, C. (2015). High performance liquid chromatography: Tandem mass spectrometric determination of cisplatin levels in different visceral pleura layers of rats. Oncology Letters, 9, 2388-2392. https://doi.org/10.3892/ol.2015.2989
MLA
Xia, H., Zhang, W., Li, Y., Yu, C."High performance liquid chromatography: Tandem mass spectrometric determination of cisplatin levels in different visceral pleura layers of rats". Oncology Letters 9.5 (2015): 2388-2392.
Chicago
Xia, H., Zhang, W., Li, Y., Yu, C."High performance liquid chromatography: Tandem mass spectrometric determination of cisplatin levels in different visceral pleura layers of rats". Oncology Letters 9, no. 5 (2015): 2388-2392. https://doi.org/10.3892/ol.2015.2989
Copy and paste a formatted citation
x
Spandidos Publications style
Xia H, Zhang W, Li Y and Yu C: High performance liquid chromatography: Tandem mass spectrometric determination of cisplatin levels in different visceral pleura layers of rats. Oncol Lett 9: 2388-2392, 2015.
APA
Xia, H., Zhang, W., Li, Y., & Yu, C. (2015). High performance liquid chromatography: Tandem mass spectrometric determination of cisplatin levels in different visceral pleura layers of rats. Oncology Letters, 9, 2388-2392. https://doi.org/10.3892/ol.2015.2989
MLA
Xia, H., Zhang, W., Li, Y., Yu, C."High performance liquid chromatography: Tandem mass spectrometric determination of cisplatin levels in different visceral pleura layers of rats". Oncology Letters 9.5 (2015): 2388-2392.
Chicago
Xia, H., Zhang, W., Li, Y., Yu, C."High performance liquid chromatography: Tandem mass spectrometric determination of cisplatin levels in different visceral pleura layers of rats". Oncology Letters 9, no. 5 (2015): 2388-2392. https://doi.org/10.3892/ol.2015.2989
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