Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
May-2015 Volume 9 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2015 Volume 9 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Gelsolin regulates proliferation, apoptosis, migration and invasion in human oral carcinoma cells

  • Authors:
    • Runzhi Deng
    • Jing Hao
    • Wei Han
    • Yanhong Ni
    • Xiaofeng Huang
    • Qingang Hu
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Stomatology, Medical School, Nanjing University, Nanjing, Jiangsu, P.R. China, Central Laboratory of Nanjing Stomatological Hospital, Nanjing, Jiangsu, P.R. China
  • Pages: 2129-2134
    |
    Published online on: March 2, 2015
       https://doi.org/10.3892/ol.2015.3002
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Gelsolin (GSN) is one of the most abundant actin‑binding proteins, and is involved in several pathological processes, including Alzheimer’s disease, cardiac injury and cancer. The aim of the present study was to assess the effect of GSN on the growth and motility of oral squamous cell carcinoma Tca8113 cells. The overexpression vector pcDNA3.1‑GSN was transfected into Tca8113 cells and the stable GSN overexpression cell line was identified based on G418 antibiotic selection. The effect of GSN overexpression on the proliferation, apoptosis, migration and invasion of Tca8113 cells was examined using a cell counting kit‑8 assay, flow cytometry and Transwell assays. The results revealed that GSN overexpression significantly promoted the cell proliferation and apoptosis of Tca8113 cells. In addition, Transwell assays demonstrated that the migration and invasion abilities of Tca8113 cells were enhanced by GSN overexpression. Therefore, the upregulation of GSN promotes cell growth and motility, indicating that it may perform a vital function in the progression of human oral cancers.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Uribe R and Jay D: A review of actin binding proteins: new perspectives. Mol Biol Rep. 36:121–125. 2009. View Article : Google Scholar : PubMed/NCBI

2 

dos Remedios CG, Chhabra D, Kekic M, et al: Actin binding proteins: regulation of cytoskeletal microfilaments. Physiol Rev. 83:433–473. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Winder SJ and Ayscough KR: Actin-binding proteins. J Cell Sci. 118:651–654. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Dominguez R: Actin-binding proteins - a unifying hypothesis. Trends Biochem Sci. 29:572–578. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Janmey PA and Chaponnier C: Medical aspects of the actin cytoskeleton. Curr Opin Cell Biol. 7:111–117. 1995. View Article : Google Scholar : PubMed/NCBI

6 

Pollard TD and Borisy GG: Cellular motility driven by assembly and disassembly of actin filaments. Cell. 112:453–465. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Li GH, Arora PD, Chen Y, McCulloch CA and Liu P: Multifunctional roles of gelsolin in health and diseases. Med Res Rev. 32:999–1025. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Shieh DB, Chen IW, Wei TY, et al: Tissue expression of gelsolin in oral carcinogenesis progression and its clinicopathological implications. Oral Oncol. 42:599–606. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Mullauer L, Fujita H, Ishizaki A and Kuzumaki N: Tumor-suppressive function of mutated gelsolin in ras-transformed cells. Oncogene. 8:2531–2536. 1993.PubMed/NCBI

10 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Siegel R, Naishadham D and Jemal A: Cancer statistics. 2012. CA Cancer J Clin. 62:10–29. 2012. View Article : Google Scholar

12 

Nomura H, Uzawa K, Ishigami T, et al: Clinical significance of gelsolin-like actin-capping protein expression in oral carcinogenesis: an immunohistochemical study of premalignant and malignant lesions of the oral cavity. BMC Cancer. 8:392008. View Article : Google Scholar : PubMed/NCBI

13 

Petersen PE: Oral cancer prevention and control - the approach of the World Health Organization. Oral Oncol. 45:454–460. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Tsantoulis PK, Kastrinakis NG, Tourvas AD, Laskaris G and Gorgoulis VG: Advances in the biology of oral cancer. Oral Oncol. 43:523–534. 2007. View Article : Google Scholar : PubMed/NCBI

15 

da Silva SD, Ferlito A, Takes RP, et al: Advances and applications of oral cancer basic research. Oral Oncol. 47:783–791. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Sciubba JJ: Oral cancer. The importance of early diagnosis and treatment. Am J Clin Dermatol. 2:239–251. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Ayscough KR: In vivo functions of actin-binding proteins. Curr Opin Cell Biol. 10:102–111. 1998. View Article : Google Scholar : PubMed/NCBI

18 

Tanaka M, Mullauer L, Ogiso Y, et al: Gelsolin: a candidate for suppressor of human bladder cancer. Cancer Res. 55:3228–3232. 1995.PubMed/NCBI

19 

Noske A, Denkert C, Schober H, et al: Loss of Gelsolin expression in human ovarian carcinomas. Eur J Cancer. 41:461–469. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Dosaka-Akita H, Hommura F, Fujita H, et al: Frequent loss of gelsolin expression in non-small cell lung cancers of heavy smokers. Cancer Res. 58:322–327. 1998.PubMed/NCBI

21 

Winston JS, Asch HL, Zhang PJ, Edge SB, Hyland A and Asch BB: Downregulation of gelsolin correlates with the progression to breast carcinoma. Breast Cancer Res Treat. 65:11–21. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Kim JH, Choi YK, Kwon HJ, Yang HK, Choi JH and Kim DY: Downregulation of gelsolin and retinoic acid receptor beta expression in gastric cancer tissues through histone deacetylase 1. J Gastroenterol Hepatol. 19:218–224. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Ni XG, Zhou L, Wang GQ, et al: The ubiquitin-proteasome pathway mediates gelsolin protein downregulation in pancreatic cancer. Mol Med. 14:582–589. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Shieh DB, Godleski J, Herndon JE II, et al: Cell motility as a prognostic factor in Stage I nonsmall cell lung carcinoma: the role of gelsolin expression. Cancer. 85:47–57. 1999. View Article : Google Scholar : PubMed/NCBI

25 

Liao CJ, Wu TI, Huang YH, et al: Overexpression of gelsolin in human cervical carcinoma and its clinicopathological significance. Gynecol Oncol. 120:135–144. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Silacci P, Mazzolai L, Gauci C, Stergiopulos N, Yin HL and Hayoz D: Gelsolin superfamily proteins: key regulators of cellular functions. Cell Mol Life Sci. 61:2614–2623. 2004. View Article : Google Scholar : PubMed/NCBI

27 

An JH, Kim JW, Jang SM, Kim CH, Kang EJ and Choi KH: Gelsolin negatively regulates the activity of tumor suppressor p53 through their physical interaction in hepatocarcinoma HepG2 cells. Biochem Biophys Res Commun. 412:44–49. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Koya RC, Fujita H, Shimizu S, et al: Gelsolin inhibits apoptosis by blocking mitochondrial membrane potential loss and cytochrome c release. J Biol Chem. 275:15343–15349. 2000. View Article : Google Scholar : PubMed/NCBI

29 

Kusano H, Shimizu S, Koya RC, et al: Human gelsolin prevents apoptosis by inhibiting apoptotic mitochondrial changes via closing VDAC. Oncogene. 19:4807–4814. 2000. View Article : Google Scholar : PubMed/NCBI

30 

Kwiatkowski DJ: Functions of gelsolin: motility, signaling, apoptosis, cancer. Curr Opin Cell Biol. 11:103–108. 1999. View Article : Google Scholar : PubMed/NCBI

31 

Sakurai N and Utsumi T: Posttranslational N-myristoylation is required for the anti-apoptotic activity of human tGelsolin, the C-terminal caspase cleavage product of human gelsolin. J Biol Chem. 281:14288–14295. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Azuma T, Koths K, Flanagan L and Kwiatkowski D: Gelsolin in complex with phosphatidylinositol 4,5-bisphosphate inhibits caspase-3 and-9 to retard apoptotic progression. J Biol Chem. 275:3761–3766. 2000. View Article : Google Scholar : PubMed/NCBI

33 

Galluzzi L and Kroemer G: Mitochondrial apoptosis without VDAC. Nat Cell Biol. 9:487–489. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Baines CP, Kaiser RA, Sheiko T, Craigen WJ and Molkentin JD: Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death. Nat Cell Biol. 9:550–555. 2007. View Article : Google Scholar : PubMed/NCBI

35 

Hanahan D and Weinberg RA: Hallmarks of cancer: the next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Ke H, Parron VI, Reece J, Zhang JY, Akiyama SK and French JE: BCL2 inhibits cell adhesion, spreading, and motility by enhancing actin polymerization. Cell Res. 20:458–469. 2010. View Article : Google Scholar : PubMed/NCBI

37 

De Corte V, Bruyneel E, Boucherie C, Mareel M, Vandekerckhove J and Gettemans J: Gelsolin-induced epithelial cell invasion is dependent on Ras-Rac signaling. EMBO J. 21:6781–6790. 2002. View Article : Google Scholar : PubMed/NCBI

38 

Azuma T, Witke W, Stossel TP, Hartwig JH and Kwiatkowski DJ: Gelsolin is a downstream effector of rac for fibroblast motility. EMBO J. 17:1362–1370. 1998. View Article : Google Scholar : PubMed/NCBI

39 

Radwanska A, Litwin M, Nowak D, et al: Overexpression of lumican affects the migration of human colon cancer cells through up-regulation of gelsolin and filamentous actin reorganization. Exp Cell Res. 318:2312–2323. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Litwin M, Nowak D, Mazur AJ, Baczynska D, Mannherz HG and Malicka-Blaszkiewicz M: Gelsolin affects the migratory ability of human colon adenocarcinoma and melanoma cells. Life Sci. 90:851–861. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Deng R, Hao J, Han W, Ni Y, Huang X and Hu Q: Gelsolin regulates proliferation, apoptosis, migration and invasion in human oral carcinoma cells. Oncol Lett 9: 2129-2134, 2015.
APA
Deng, R., Hao, J., Han, W., Ni, Y., Huang, X., & Hu, Q. (2015). Gelsolin regulates proliferation, apoptosis, migration and invasion in human oral carcinoma cells. Oncology Letters, 9, 2129-2134. https://doi.org/10.3892/ol.2015.3002
MLA
Deng, R., Hao, J., Han, W., Ni, Y., Huang, X., Hu, Q."Gelsolin regulates proliferation, apoptosis, migration and invasion in human oral carcinoma cells". Oncology Letters 9.5 (2015): 2129-2134.
Chicago
Deng, R., Hao, J., Han, W., Ni, Y., Huang, X., Hu, Q."Gelsolin regulates proliferation, apoptosis, migration and invasion in human oral carcinoma cells". Oncology Letters 9, no. 5 (2015): 2129-2134. https://doi.org/10.3892/ol.2015.3002
Copy and paste a formatted citation
x
Spandidos Publications style
Deng R, Hao J, Han W, Ni Y, Huang X and Hu Q: Gelsolin regulates proliferation, apoptosis, migration and invasion in human oral carcinoma cells. Oncol Lett 9: 2129-2134, 2015.
APA
Deng, R., Hao, J., Han, W., Ni, Y., Huang, X., & Hu, Q. (2015). Gelsolin regulates proliferation, apoptosis, migration and invasion in human oral carcinoma cells. Oncology Letters, 9, 2129-2134. https://doi.org/10.3892/ol.2015.3002
MLA
Deng, R., Hao, J., Han, W., Ni, Y., Huang, X., Hu, Q."Gelsolin regulates proliferation, apoptosis, migration and invasion in human oral carcinoma cells". Oncology Letters 9.5 (2015): 2129-2134.
Chicago
Deng, R., Hao, J., Han, W., Ni, Y., Huang, X., Hu, Q."Gelsolin regulates proliferation, apoptosis, migration and invasion in human oral carcinoma cells". Oncology Letters 9, no. 5 (2015): 2129-2134. https://doi.org/10.3892/ol.2015.3002
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team