Budd‑Chiari syndrome, a rare complication of multicentric Castleman disease: A case report

Song,Kui; Li,Min

doi:10.3892/ol.2015.3010

May-2015 Volume 9 Issue 5

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May-2015 Volume 9 Issue 5

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Case Report

Budd‑Chiari syndrome, a rare complication of multicentric Castleman disease: A case report

Authors:
- Kui Song
- Min Li
View Affiliations / Copyright

Affiliations: Department of Hematology, The First Affiliated Hospital of Jishou University, Jishou, Hunan 416000, P.R. China, Department of Pharmacy, The First Affiliated Hospital of Jishou University, Jishou, Hunan 416000, P.R. China
Pages: 2153-2156
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Published online on: March 3, 2015

https://doi.org/10.3892/ol.2015.3010
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Abstract

A 39‑year‑old female presented to The First Affiliated Hospital of Jishou University (Jishou, Hunan) with a fever of unknown origin and progressive abdominal distension. Physical examination revealed generalized lymphadenopathy, multiple non‑tender cutaneous nodules, hepatomegaly, splenomegaly and abdominal edema. An axillary lymph node biopsy indicated hyaline vascular type Castleman disease, and color Doppler and computed tomography scans suggested Budd‑Chiari syndrome (BCS). Based on the abdominal distension and impairments of the liver and kidneys, an inferior vena cavography and balloon dilatation were performed, confirming the diagnosis of BCS and leading to symptomatic improvement. The patient commenced a combination chemotherapy regimen of cyclophosphamide (0.4 g; days 1‑3), vindesine (4 mg; day 1) and prednisolone (100 mg; days 1‑5), with no melioration of symptoms. Theprubicin was added to suppress the aggravation of the disease on day six of the chemotherapy cycle. The patient exhibited symptomatic remission for one week, however, she subsequently succumbed to intracranial hemorrhage and infections of the lung and intestine due to long‑term myelosuppression following chemotherapy. To the best of our knowledge, this is the first report of BCS in a patient with multicentric Castleman disease without human immunodeficiency virus infection.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Budd‑Chiari syndrome, a rare complication of multicentric Castleman disease: A case report

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