Adherence and awareness of the therapeutic intent of oral anticancer agents in an outpatient setting

Kimura,Michio; Nakashima,Keiji; Usami,Eiseki; Iwai,Mina; Nakao,Toshiya; Yoshimura,Tomoaki; Mori,Hiromi; Teramachi,Hitomi

doi:10.3892/ol.2015.3027

May-2015 Volume 9 Issue 5

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

May-2015 Volume 9 Issue 5

Full Size Image

Article

Adherence and awareness of the therapeutic intent of oral anticancer agents in an outpatient setting

Authors:
- Michio Kimura
- Keiji Nakashima
- Eiseki Usami
- Mina Iwai
- Toshiya Nakao
- Tomoaki Yoshimura
- Hiromi Mori
- Hitomi Teramachi
View Affiliations / Copyright

Affiliations: Department of Pharmacy, Ogaki Municipal Hospital, Ogaki, Gifu 503‑8502, Japan, Laboratory of Clinical Pharmacy, Gifu Pharmaceutical University, Ogaki, Gifu 501-1196, Japan
Pages: 2341-2346
|
Published online on: March 11, 2015

https://doi.org/10.3892/ol.2015.3027
Expand metrics +

Abstract

The aim of the present study was to clarify the adherence and awareness of oral anticancer agents by type and therapeutic purpose in outpatients prescribed with tegafur/gimeracil/oteracil potassium (S‑1) or capecitabine. Outpatients undergoing treatment with the S‑1 or capecitabine oral anticancer agents at Ogaki Municipal Hospital (Ogaki, Japan) in June 2013 completed a questionnaire survey and the survey findings were evaluated. No significant differences in medication adherence were identified between the patients administered S‑1 and the patients administered capecitabine (P=0.4586). In addition, no significant differences were identified in therapeutic purpose between adjuvant therapy, and advanced and recurrent therapies. However, for S‑1 and capecitabine, medication adherence was significantly higher in those undergoing combination therapy compared with those undergoing monotherapy (P=0.0046). In addition, for patients taking S‑1, the median age for good adherence was significantly lower than that for insufficient adherence (66.1±10.5 vs. 72.1±7.9 years, respectively; P=0.0035). Furthermore, a significant negative correlation was identified between the awareness score of research regarding the medication and age (n=109; P=0.0045). In conclusion, for patients treated with S‑1 or capecitabine, the type and therapeutic purpose of oral anticancer agents did not affect medication adherence. Elderly patients expressed a low interest in medications and typically exhibited insufficient medication adherence. Therefore, patient guidance by pharmacists is important, as it may result in improved medication adherence and an improved understanding of the treatment side‑effects in patients self‑administering prescribed drugs.

View Figures

View References

1	Wu EQ, Guerin A, Yu AP, Bollu VK, Guo A and Griffin JD: Retrospective real-world comparison of medicalvisits, costs, and adherence betweennilotinib and dasatinib in chronic myeloid leukaemia. Curr Med Res Opin. 26:2861–2869. 2010. View Article : Google Scholar : PubMed/NCBI
2	Reginster JY: Adherence and persistence: impact onoutcomes and health care resources. Bone. 38(Suppl 2): S18–S21. 2006. View Article : Google Scholar : PubMed/NCBI
3	Kimura M, Usami E, Iwai M, Nakao T, Yoshimura T, Mori H, Sugiyama T and Taramachi H: Oral anticancer agent medication adherence by outpatients. Oncol Lett. 8:2318–2324. 2014.PubMed/NCBI
4	Macintosh PW, Pond GR, Pond BJ, Leung V and Siu LL: A comparison of patientadherence and preference of packaging method for oral anticancer agents using conventional pill bottles versus daily pill boxes. Eur J Cancer Care (Engl). 16:380–386. 2007. View Article : Google Scholar : PubMed/NCBI
5	Marin D, Bazeos A, Mahon FX, Eliasson L, Milojkovic D, Bua M, Apperley JF, Szydlo R, Desai R, Kozlowski K, et al: Adherence is the critical factor for achieving molecular responses in patients with chronic myeloid leukaemia who achieve complete cytogenetic response on imatinib. J Clin Oncol. 28:2381–2388. 2010. View Article : Google Scholar : PubMed/NCBI
6	Nilsson JL, Andersson K, Bergkvist A, Björkman I, Brismar A and Moen J: Refill adherence to repeat prescriptions of cancer drugs to ambulatory patients. Eur J Cancer Care (Engl). 15:235–237. 2006. View Article : Google Scholar : PubMed/NCBI
7	Noens L, van Lierde MA, De Bock R, Verhoef G, Zachée P, Berneman Z, Martiat P, Mineur P, Van Eygen K, MacDonald K, et al: Prevalence, determinants, and outcomes of nonadherence to imatinib therapy in patients with chronic myeloid leukaemia: the ADAGIO study. Blood. 113:5401–5411. 2009. View Article : Google Scholar : PubMed/NCBI
8	Partridge AH, Archer L, Kornblith AB, Gralow J, Grenier D, Perez E, Wolff AC, Wang X, Kastrissios H, Berry D, et al: Adherence and persistence with oral adjuvant chemotherapy in older women with early-stage breast cancer in CALGB 49907: adherence companion study 60104. J Clin Oncol. 28:2418–2422. 2010. View Article : Google Scholar : PubMed/NCBI
9	Sakuramoto S, Sasako M, Yamaguchi T, et al: ACTS-GC Group: Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine. N Engl J Med. 357:1810–1820. 2007. View Article : Google Scholar : PubMed/NCBI
10	Gore ME, Szczylik C, Porta C, et al: Safety and efficacy of sunitinib for metastatic renal-cell carcinoma: an expanded-access trial. Lancet Oncol. 10:757–763. 2009. View Article : Google Scholar : PubMed/NCBI
11	Escudier B, Eisen T, Stadler WM, et al: Sorafenib for treatment of renal cell carcinoma: Finalefficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial. J Clin Oncol. 27:3312–3318. 2009. View Article : Google Scholar : PubMed/NCBI
12	Ruddy K, Mayer E and Partridge A: Patientadherence and persistence with oral anticancer treatment. CA Cancer J Clin. 59:56–66. 2009. View Article : Google Scholar : PubMed/NCBI
13	Russmann S, Curkovic I and Huber M: Adversereactions and risks associated with non compliance. Ther Umsch. 67:303–307. 2010.[In German]. View Article : Google Scholar : PubMed/NCBI
14	Winkeljohn D: Adherence to oral cancer therapies: nursing interventions. Clin J Oncol Nurs. 14:461–466. 2010. View Article : Google Scholar : PubMed/NCBI
15	Hasegawa K, Kuritani Y, Adachi A, Shinke K, Nishii S and Fujita Y: Improvement of drugcompliance and pharmaceutical care - types ofdrug and dosing regimens desired by patients. Jpn J Pharm Health Care Sci. 34:800–804. 2008.[In Japanese]. View Article : Google Scholar
16	Tsuboi K, Teramachi H, Kuzuya Y, Mizui T, Goto C and Tsuchiya T: Survey of the patients' consciousness affecting medication adherence. Jpn J Pharm Health Care Sci. 38:522–533. 2012.[In Japanese]. View Article : Google Scholar
17	Tsang J, Rudychev I and Pescatore SL: Prescription compliance and persistency in chronic myelogenous leukaemia (CML) and gastrointestinal stromal tumor (GIST) patients (pts) on imatinib (IM). J Clin Oncol (Meeting Abstracts; Suppl). 24:61192006.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Adherence and awareness of the therapeutic intent of oral anticancer agents in an outpatient setting

This article is mentioned in:

Abstract

Related Articles