Ovarian cancer transformation from adenocarcinoma to undifferentiated small cell carcinoma: A case report

Huang,Zuo Ping; Liu,Xing Jing; Zou,Bin Xin; Shen,Qian; Liu,Ying; Zhou,Tao

doi:10.3892/ol.2015.3031

May-2015 Volume 9 Issue 5

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

May-2015 Volume 9 Issue 5

Full Size Image

Case Report

Ovarian cancer transformation from adenocarcinoma to undifferentiated small cell carcinoma: A case report

Authors:
- Zuo Ping Huang
- Xing Jing Liu
- Bin Xin Zou
- Qian Shen
- Ying Liu
- Tao Zhou
View Affiliations / Copyright

Affiliations: Department of Oncology, The Affiliated Wujing Hospital of Guangzhou Medical College, State Key Laboratory of Respiratory Disease, Guangzhou, Guangdong 510507, P.R. China
Pages: 2230-2232
|
Published online on: March 12, 2015

https://doi.org/10.3892/ol.2015.3031
Expand metrics +

Abstract

The ovaries contain cells that have the capacity for regeneration and cancer stem cells (CSC) that are capable of differentiating aberrantly from the homeostatic controls. The histology of ovarian cancer does not usually change in a patient. However, CSCs are the origin of a number of tumors. CSCs are known to exist in ovarian carcinomas and the expression of CD44, c-Kit and CD133 has been identified in such carcinomas. This study presents the case of a patient diagnosed with ovarian cancer with an abdominal mass who underwent surgery, eight cycles of gemcitabine-paclitaxel chemotherapy and irradiation. Pathological examination indicated a transformation from adenocarcinoma to undifferentiated small cell carcinoma. The expression of CD133 changed from negative to positive in ovarian carcinomas. The present case indicates that any histological changes observed in ovarian neoplasms originate from neoplastic stem cells. In addition, this case demonstrates the importance of repeatedly assessing therapy by tumor biopsy throughout the course of ovarian cancer treatment.

View Figures

View References

1	López J, Valdez-Morales FJ, Benítez-Bribiesca L, Cerbón M and Carrancá AG: Normal and cancer stem cells of the human female reproductive system. Reprod Biol Endocrinol. 11:532013. View Article : Google Scholar : PubMed/NCBI
2	Bapat SA, Mali AM, Koppikar CB and Kurrey NK: Stem and progenitor-like cells contribute to the aggressive behavior of human epithelial ovarian cancer. Cancer Res. 65:3025–3029. 2005.PubMed/NCBI
3	Shepherd JH: Revised FIGO staging for gynaecological cancer. Br J Obstet Gynaecol. 96:889–892. 1989. View Article : Google Scholar : PubMed/NCBI
4	Zhang H, Zhang B, Tao Y, Cheng M, Hu J, Xu M and Chen H: Isolation and characterization of mesenchymal stem cells from whole human umbilical cord applying a single enzyme approach. Cell Biochem Funct. 30:643–649. 2012. View Article : Google Scholar : PubMed/NCBI
5	Yang X, Takano Y and Zheng HC: The pathobiological features of gastrointestinal cancers (Review). Oncol Lett. 3:961–969. 2012.PubMed/NCBI
6	Bosland MC: Sexsteroids and prostatecarcinogenesis: integrated, multifactorial working hypothesis. Ann NY Acad Sci. 1089:168–176. 2006. View Article : Google Scholar : PubMed/NCBI
7	Finch AJ, Soucek L, Junttila MR, Swigart LB and Evan GI: Acute overexpression of Myc in intestinal epithelium recapitulates some but not all the changes elicited by Wnt/beta-catenin pathway activation. Mol Cell Biol. 29:5306–5315. 2009. View Article : Google Scholar : PubMed/NCBI
8	Fu W, Madan E, Yee M and Zhang H: Progress of molecular targeted therapies for prostate cancers. Biochim Biophys Acta. 1825:140–152. 2012.PubMed/NCBI
9	Sequist LV, Waltman BA, Dias-Santagata D, Digumarthy S, Turke AB, Fidias P, Bergethon K, Shaw AT, Gettinger S, Cosper AK, Akhavanfard S, Heist RS, Temel J, Christensen JG, Wain JC, Lynch TJ, Vernovsky K, Mark EJ, Lanuti M, Iafrate AJ, Mino-Kenudson M and Engelman JA: Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci Transl Med. 3:75ra262011. View Article : Google Scholar : PubMed/NCBI
10	Zakowski MF, Ladanyi M and Kris MG: Memorial Sloan-Kettering Cancer Center Lung Cancer OncoGenome Group: EGFR mutations in small-cell lung cancers in patients who have never smoked. N Engl J Med. 355:213–215. 2006. View Article : Google Scholar : PubMed/NCBI
11	Tatematsu A, Shimizu J, Murakami Y, Horio Y, Nakamura S, Hida T, Mitsudomi T and Yatabe Y: Epidermal growth factor receptor mutations in small cell lung cancer. Clin Cancer Res. 14:6092–6096. 2008. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Ovarian cancer transformation from adenocarcinoma to undifferentiated small cell carcinoma: A case report

This article is mentioned in:

Abstract

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Related Articles